53 research outputs found
Two harmonic Jacobi--Davidson methods for computing a partial generalized singular value decomposition of a large matrix pair
Two harmonic extraction based Jacobi--Davidson (JD) type algorithms are
proposed to compute a partial generalized singular value decomposition (GSVD)
of a large regular matrix pair. They are called cross product-free (CPF) and
inverse-free (IF) harmonic JDGSVD algorithms, abbreviated as CPF-HJDGSVD and
IF-HJDGSVD, respectively. Compared with the standard extraction based JDGSVD
algorithm, the harmonic extraction based algorithms converge more regularly and
suit better for computing GSVD components corresponding to interior generalized
singular values. Thick-restart CPF-HJDGSVD and IF-HJDGSVD algorithms with some
deflation and purgation techniques are developed to compute more than one GSVD
components. Numerical experiments confirm the superiority of CPF-HJDGSVD and
IF-HJDGSVD to the standard extraction based JDGSVD algorithm.Comment: 24 pages, 5 figure
Fabrication of WO3·2H2O/BC Hybrids by the Radiation Method for Enhanced Performance Supercapacitors
In this study, we described a facile process for the fabrication of tungsten oxide dihydrate/bamboo charcoal hybrids (WO3·2H2O/BC) by the γ-irradiation method. The structural, morphological, and electrochemical properties of WO3·2H2O/BC hybrids were investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), cyclic voltammetry (CV), galvanostatic charge/discharge (GCD), and electrochemical impedance spectroscopy (EIS) techniques. The combination of BC (electrical double layer charge) and WO3·2H2O (pseudocapacitance) created a combined effect, which enhanced the specific capacitance and superior cyclic stability of the WO3·2H2O/BC hybrid electrode. The WO3·2H2O/BC hybrids showed the higher specific capacitance (391 F g−1 at 0.5 A g−1 over the voltage range from −1 to 0 V), compared with BC (108 F g−1) in 6 M KOH solution. Furthermore, the hybrid electrode showed superior long-term performance with 82% capacitance retention even after 10,000 cycles. The experimental results demonstrated that the high performance of WO3·2H2O/BC hybrids could be a potential electrode material for supercapacitors
catena-Poly[[[aqua(7-hydroxy-2H-1-benzopyran-2-one)sodium]-di-μ-aqua] 2-oxo-2H-1-benzopyran-7-olate monohydrate]
The asymmetric unit of the title compound, {[Na(C9H6O3)(H2O)3](C9H5O3)·H2O}n, contains two crystallographically independent Na atoms, two 7-hydroxycoumarin ligands, six coordinated water molecules, two 7-hydroxycoumarin anions and two uncoordinated water molecules. Both Na atoms exhibit a distorted octahedral coordination geometry and are coordinated by five water O atoms and the terminal O atom from a 7-hydroxycoumarin ligand. Four of the water molecules are bridging, whereas the fifth is terminal. Na—O bond distances are in the range 2.288 (2)–2.539 (2) Å. In the chains, extending parallel to [100], adjacent Na atoms are separated by 3.60613 (7) Å. The uncoordinated water molecules and 7-hydroxycoumarin phenolate anions are located between the chains and are hydrogen bonded to the chains
Identification of the osteoarthritis signature gene PDK1 by machine learning and its regulatory mechanisms on chondrocyte autophagy and apoptosis
BackgroundOsteoarthritis (OA) is a degenerative joint disease frequently diagnosed in the elderly and middle-aged population. However, its specific pathogenesis has not been clarified. This study aimed to identify biomarkers for OA diagnosis and elucidate their potential mechanisms for restoring OA-dysregulated autophagy and inhibiting chondrocyte apoptosis in vitro.Material and methodsTwo publicly available transcriptomic mRNA OA-related datasets (GSE10575 and GSE51588) were explored for biomarker identification by least absolute shrinkage and selection operator (LASSO) regression, weighted gene co-expression network analysis (WGCNA), and support vector machine recursive feature elimination (SVM-RFE). We applied the GSE32317 and GSE55457 cohorts to validate the markers’ efficacy for diagnosis. The connections of markers to chondrocyte autophagy and apoptosis in OA were also comprehensively explored in vitro using molecular biology approaches, including qRT-PCR and Western blot.ResultsWe identified 286 differentially expressed genes (DEGs). These DEGs were enriched in the ECM-receptor interaction and PI3K/AKT signaling pathway. After external cohort validation and protein-protein interaction (PPI) network construction, PDK1 was finally identified as a diagnostic marker for OA. The pharmacological properties of BX795-downregulated PDK1 expression inhibited LPS-induced chondrocyte inflammation and apoptosis and rescued OA-dysregulated autophagy. Additionally, the phosphorylation of the mediators associated with the MAPK and PI3K/AKT pathways was significantly downregulated, indicating the regulatory function of PDK1 in apoptosis and autophagy via MAPK and PI3K/AKT-associated signaling pathways in chondrocytes. A significantly positive association between the PDK1 expression and Neutrophils, Eosinophils, Plasma cells, and activated CD4 memory T cells, as well as an evident negative correlation between T cells follicular helper and CD4 naive T cells, were detected in the immune cell infiltration analysis.ConclusionsPDK1 can be used as a diagnostic marker for OA. Inhibition of its expression can rescue OA-dysregulated autophagy and inhibit apoptosis by reducing the phosphorylation of PI3K/AKT and MAPK signaling pathways
Rescue robot swing arm driving system and its balance control method
For limitation of the maximum permitted size and weight, a mine rescue robot(MRR) swing arm driving system was designed by taking a form of single-inverter driving dual-motor. The system model was built by use of weighted sum method, and current relationship of the dual-motor of the model was deduced and analyzed. For inconsistent MRR swing arm loads caused by complicated working conditions in coal mine underground, a balance control method for the system was proposed based on active damping mechanism. The method was tested by use of a 15 kW MRR prototype, and the result shows that the method can realize dynamic matching of torque under condition of inconsistent MRR swing arm loads
Observer-Based Distributed Fault Detection for Heterogeneous Multi-Agent Systems
This paper solves the distributed fault detection (FD) problem for heterogeneous multi-agent systems (MAS). For a heterogeneous MAS, we adopt a distributed control law to realise cooperative output regulation (COR) when no fault occurs in the MAS, and propose a state-feedback-based FD scheme, where the adopted distributed control law and proposed FD scheme all utilise state information. Furthermore, we consider the condition that state information is unmeasurable, the output-feedback-based distributed FD scheme is proposed, and the adopted distributed control law also utilises measurement output. Finally, two numerical examples are utilised to verify that the proposed distributed FD schemes could locate and remove the faulty agent in time
Biochemical characterization of two thermostable xylanolytic enzymes encoded by a gene cluster of Caldicellulosiruptor owensensis.
The xylanolytic extremely thermophilic bacterium Caldicellulosiruptor owensensis provides a promising platform for xylan utilization. In the present study, two novel xylanolytic enzymes, GH10 endo-β-1,4-xylanase (Coxyn A) and GH39 β-1,4-xylosidase (Coxyl A) encoded in one gene cluster of C.owensensis were heterogeneously expressed and biochemically characterized. The optimum temperature of the two xylanlytic enzymes was 75°C, and the respective optimum pH for Coxyn A and Coxyl A was 7.0 and 5.0. The difference of Coxyn A and Coxyl A in solution was existing as monomer and homodimer respectively, it was also observed in predicted secondary structure. Under optimum condition, the catalytic efficiency (kcat/Km) of Coxyn A was 366 mg ml(-1) s(-1) on beechwood xylan, and the catalytic efficiency (kcat/Km) of Coxyl A was 2253 mM(-1) s(-1) on pNP-β-D-xylopyranoside. Coxyn A degraded xylan to oligosaccharides, which were converted to monomer by Coxyl A. The two intracellular enzymes might be responsible for xylooligosaccharides utilization in C.owensensis, also provide a potential way for xylan degradation in vitro
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