catena-Poly[[[aqua(7-hydroxy-2H-1-benzopyran-2-one)sodium]-di-μ-aqua] 2-oxo-2H-1-benzopyran-7-olate monohydrate]

The asymmetric unit of the title compound, {[Na(C9H6O3)(H2O)3](C9H5O3)·H2O}n, contains two crystallographically independent Na atoms, two 7-hy­droxy­coumarin ligands, six coordinated water mol­ecules, two 7-hy­droxy­coumarin anions and two uncoordinated water mol­ecules. Both Na atoms exhibit a distorted octa­hedral coordination geometry and are coordinated by five water O atoms and the terminal O atom from a 7-hy­droxy­coumarin ligand. Four of the water mol­ecules are bridging, whereas the fifth is terminal. Na—O bond distances are in the range 2.288 (2)–2.539 (2) Å. In the chains, extending parallel to [100], adjacent Na atoms are separated by 3.60613 (7) Å. The uncoordinated water mol­ecules and 7-hy­droxy­coumarin phenolate anions are located between the chains and are hydrogen bonded to the chains

Stable Li Metal Anode Enabled by Space Confinement and Uniform Curvature through Lithiophilic Nanotube Arrays

The application of lithium (Li) metal anodes in rechargeable batteries is primarily restricted by Li dendrite growth on the metal’s surface, which leads to shortened cycle life and safety concerns. Herein, well‐spaced nanotubes with ultrauniform surface curvature are introduced as a Li metal anode structure. The ultrauniform nanotubular surface generates uniform local electric fields that evenly attract Li‐ions to the surface, thereby inducing even current density distribution. Moreover, the well‐defined nanotube spacing offers Li diffusion pathways to the electroactive areas as well as the confined spaces to host deposited Li. These structural attributes create a unique electrodeposition manner; i.e., Li metal homogenously deposits on the nanotubular wall, causing each Li nanotube to grow in circumference without obvious sign of dendritic formation. Thus, the full‐cell battery with the spaced Li nanotubes exhibits a high specific capacity of 132 mA h g−1 at 1 C and an excellent coulombic efficiency of ≈99.85% over 400 cycles.This work presents a technique for suppressing lithium dendrite formation through ultrauniform curvature and space confinement. Lithium uniformly deposits/dissolves on the nanotube surfaces where the local current distribution is uniform due to the ultrauniform curvature. The nanotube spacing provides confined spaces to host deposited lithium. Thus, a full‐cell battery with spaced lithium nanotubes shows excellent specific capacity at high rates.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153606/1/aenm201902819_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153606/2/aenm201902819-sup-0001-SuppMat.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153606/3/aenm201902819.pd

Design, Synthesis, and Pharmacological Evaluation of Haloperidol Derivatives as Novel Potent Calcium Channel Blockers with Vasodilator Activity

Several haloperidol derivatives with a piperidine scaffold that was decorated at the nitrogen atom with different alkyl, benzyl, or substituted benzyl moieties were synthesized at our laboratory to establish a library of compounds with vasodilator activity. Compounds were screened for vasodilatory activity on isolated thoracic aorta rings from rats, and their quantitative structure–activity relationships (QSAR) were examined. Based on the result of QSAR, N-4-tert-butyl benzyl haloperidol chloride (16c) was synthesized and showed the most potent vasodilatory activity of all designed compounds. 16c dose-dependently inhibited the contraction caused by the influx of extracellular Ca2+ in isolated thoracic aorta rings from rats. It concentration-dependently attenuated the calcium channel current and extracellular Ca2+ influx, without affecting the intracellular Ca2+ mobilization, in vascular smooth muscle cells from rats. 16c, possessing the N-4-tert-butyl benzyl piperidine structure, as a novel calcium antagonist, may be effective as a calcium channel blocker in cardiovascular disease

Experimental investigation of a novel vertical loop-heat-pipe PV/T heat and power system under different height differences

For a novel vertical solar loop-heat-pipe photovoltaic/thermal system, the height difference between evaporator and condenser plays an important role in the heat transport capacity, which has significant impact on the solar thermal efficiency and parametrical optimization of this system. Therefore, based on the results derived from the authors’ previous analytical investigation and computer modelling studies, a prototype of this novel system was designed, constructed, and an experimental investigation under different height difference was undertaken to study the impact of height difference on the system performance. It was found that the relationship between the solar thermal efficiency of this vertical system and the height difference is nonlinear. In present study, the optimal height difference is around 1.1 m, which was selected as an optimal value for the following experimental investigations, and below 1.1 m, the PV module surface temperature decreased with the increase of the height difference. Furthermore, the transient solar thermal and electrical performance of this system with the selected optimal height difference were investigated under outdoor real weather condition. These results of this experimentation can help optimize the system construction and thus help to develop the high thermal performance and low-cost solar PV/T system for space heating and power generation

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

BackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare hematopoietic malignancy, which originating from precursors of plasmacytoid dendritic cells. Allogeneic hematopoietic stem cell transplantation (HSCT) is normally considered in the treatment of BPDCN patients to acquire sustained remission. Post-transplant lymphoproliferative disorder (PTLD) is a group of conditions involving abnormal lymphoid cells proliferation in the context of extrinsic immunosuppression after solid organ transplantation (SOT) or HSCT. Herein, we report a patient with BPDCN, who suffered from PTLD after allogeneic HSCT.Case presentationA 66-year-old man was diagnosed with BPDCN, confirmed by pathologic examination after splenectomy. The post-surgery 18F-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT) showed multifocal 18F-FDG avidity in the left cheek, lymph nodes and bone marrow. The patient started chemotherapy, followed by allogeneic HSCT and immunosuppressive therapy. Four months after the HSCT, the patient developed intermittent fever and recurrent lymphadenopathy, accompanied with progressively elevated Epstein–Barr virus (EBV)-DNA both in serum and lymphocytes. 18F-FDG PET/CT was performed again and found multiple new enlarged 18F-FDG-avid lymph nodes, while the previous hypermetabolic lesions all disappeared. The pathology of mesenteric lymph node indicated a monomorphic PTLD (diffuse large B-cell lymphoma). Then the immunosuppressive medications were stopped and two cycles of Rituximab were given, and the follow-up CT scan indicated a complete response.ConclusionWhen patients with BPDCN recurred new enlarged lymph nodes after allogeneic HSCT and immunosuppressive therapy, PTLD should be taken into consideration. 18F-FDG PET/CT may provide additional evidence for supporting or refuting the suspicion of PTLD, and suggest lesions accessible for biopsy

Development and Application of a Multiple Cross Displacement Amplification Combined With Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Candida tropicalis

Candida tropicalis is an increasingly opportunistic pathogen that causes serious invasive candidiasis threatening a patient’s life. Traditional methods to detect C. tropicalis infection depends on time-consuming, culture-based gold-standard methods. So, we sought to establish a new method that could detect target pathogens quickly, accurately, and straightforwardly. Herein, a combination of multiple cross displacement amplification (MCDA) and lateral flow biosensors (LFB) was employed to detect C. tropicalis. In the MCDA system, 10 primers were designed to identify the specific genes of C. tropicalis and amplify the genes in an isothermal amplification device. Then, MCDA amplification reaction products could be identified visibly by color change, and all the amplification products would be tested by LFB with no special equipment. The results demonstrated that the optimal reaction condition of C. tropicalis-MCDA assay was 64°C within 30 min, and only 10 fg DNA was required in each reaction. No cross-reaction was found between C. tropicalis strains and non-C. tropicalis strains. For 300 sputum samples, the results showed that MCDA-LFB assay could rapidly and successfully detect all of the C. tropicalis-positive (28/300) samples detected by the gold-standard method. The entire procedure, including specimen processing (40 min), isothermal reaction (30 min) and result reporting (within 2 min), could be completed within 75 min. Briefly, the study results demonstrated that the detection ability of C. tropicalis-MCDA-LFB assay was better than culture methods with more simplicity, rapidity, sensitivity and specificity. Hence, MCDA-LFB strategy is an effective tool to rapidly detect C. tropicalis in clinical samples, especially in resource-poor areas