7 research outputs found

    Incentive Mechanism of Enterprises Energy-saving and Emission Reduction Based on Rank Order Tournaments

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    AbstractThe article establishes the analytical framework of incentive mechanism and the rank order tournaments model that based on the relative performance for developing energy-saving and emission reduction by using the theory of principle-agent and the Malcomson model. We systematically analyzes the model, and proposes the corresponding policy suggestions

    Effect Analysis on the Industrial Upgrading and Economic Growth

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    Using literature review and data analysis, this paper elaborates the connotation and the necessity of industrial upgrading, and focuses on interactive effect of the industrial upgrading and economic growth in Ji’nan by analyzing its growth and the proportion of each industry. According to the results, industrial upgrading is the strong driving force of economic development, similarly, industrial upgrading is also included in the economic development. The industrial upgrading of Ji’nan has made some achievements but problems still exist, for example, how to create the industry system with Ji’nan characteristics, promote industrial upgrading, and realize the sustainable development of Ji’nan economy

    Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis

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    Abstract Background Polycystic ovary syndrome (PCOS) is an endocrine disease that increases the risk of infertility. Circular RNAs (circRNAs) play important roles in regulating the biological processes of PCOS. Our study was designed to explore the function of circ-FURIN in PCOS. Methods Circ-FURIN expression was detected using RT-qPCR. The protein expression of AVEN, BCL2, XIAP and AREL1 was measured using western blot. Dual-luciferase reporter and RNA pull-down assays were applied to clarify the interaction between miR-195-5p and circ-FURIN or BCL2. Functionally, cell proliferation was assessed by MTT and colony formation assays. Cell apoptosis was analyzed by flow cytometry. Results Circ-FURIN was upregulated in PCOS patients and granular cells (GCs). Knockdown of circ-FURIN inhibited cell proliferation and promoted apoptosis of KGN cells, along with the increased expression of caspase-3 and Bax and the decreased levels of p-PI3K. Gene ontology (GO) analysis indicated circ-FURIN is associated with apoptotic signaling pathway and cell death. Subsequently, BCL2 expression was elevated in patients with PCOS and positively regulated by circ-FURIN. Furthermore, circ-FURIN was served as a sponge of miR-195-5p to directly target to BCL2. The levels of miR-195-5p were reduced in PCOS and KGN cells. Knockdown of circ-FURIN decreased the expression of BCL2, which was abolished by miR-195-5p inhibitor. At last, rescue experiments revealed that overexpression of BCL2 reversed the effects of circ-FURIN knockdown on cell proliferation and apoptosis of KGN cells. Conclusions Loss of circ-FURIN alleviated the development of PCOS via miR-195-5p/BCL2 axis. Circ-FURIN may be the novel biomarker for PCOS

    Enhanced Frequency Conversion in Parity-Time Symmetry Line

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    Non-Hermitian degeneracies reveal intriguing and non-trivial behaviors in open physical systems. Examples like Parity-Time (PT) symmetry breaking, topological encircling chirality, and enhanced sensing near an exceptional point (EP) are often associated with the abrupt nature of the phase transition around these degeneracies. Here we experimentally observe a cavity-enhanced second-harmonic frequency (SHG) conversion on a PT symmetry line, i.e. a set consisting of open-ended isofrequency or isoloss lines, both terminated at EPs on the Riemann surface in parameter space. The enhancement factor can reach as high as 300, depending on the crossing point whether in the symmetry or the broken phase of the PT line. Moreover, such enhancement of SHG enables sensitive distance sensing with a nanometer resolution. Our works may pave the way for practical applications in sensing, frequency conversion, and coherent wave control

    Subwavelength Photorefractive Grating in a Thin-Film Lithium Niobate Microcavity

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    Subwavelength gratings play a fundamental and pivotal role in numerous science and applications for wave manipulation, exhibiting distinctive features such as filtering, phase manipulation, and anti-reflection. However, conventional fabrication methods for ultrasmall periodic structures are constrained by the fundamental optical diffraction limit, making it challenging to produce subwavelength gratings for optics. Here, we demonstrate a novel technique to build a reconfigurable subwavelength photorefractive grating (SPG) in a thin-film lithium niobate on the platform of an optical microcavity. Such SPGs are optically induced through the photorefractive effect and the subwavelength features originate from the spatial phase modulations of the pump's standing wave. The resulting SPGs lead to the mode splitting of two counter-propagating modes inside the microcavity, exhibiting an Electromagnetically Induced Transparency (EIT)-like transmission spectrum. Moreover, the unique subwavelength characteristic of SPGs enables first-order quasi-phase-matching for backward second-harmonic generation, a long-standing problem in nonlinear optics. Also, free-space-to-chip vertical nonlinear frequency conversion can be achieved in a similar manner. These results provide a flexible approach towards fabricating subwavelength gratings, which holds significant potential in various applications such as nonlinear frequency conversion, optical communication, sensing, and quantum technologies
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