A Cognitive Analysis of Conceptual Metaphors in Chinese and English Volleyball Sports News Reports

With the development of human civilization and people’s material and cultural life, sports events play an increasingly important role in human’s life. Metaphors can facilitate people’s understanding of sports news and attract people’s attention. The present study conducts a comparative study of Chinese and English Rio Olympic sports, aiming to answer the following questions: (1) What are the typical conceptual metaphors in Chinese and English Rio Olympic news reports on the Woman’s Volleyball Final Game? (2) What are the similarities and differences of conceptual metaphors’ frequencies of occurrence between Chinese and English Rio Olympic news reports on the Woman’s Volleyball final game? Based on the analysis, the cognitive mechanism of typical conceptual metaphor is elaborated as well as the similarities and differences of conceptual metaphor in Chinese and English volleyball news reports

Communicating telecom fraud risk in anti-telefraud messages: The effects of metaphorical frames on attitudes

IntroductionWith the frequent occurrences of telecom fraud crimes in China, it is very necessary and urgent to carry out effective anti-telefraud risk communication. In the present study, we investigated the role of metaphorical framing in shaping people’s attitudes toward telecom fraud in anti-telefraud messages through two experiments.MethodsParticipants (N = 547, Experiment 1; N = 604, Experiment 2) were randomly assigned to war-framing, disease-framing, or issue-framing conditions. They were asked to read anti-telefraud messages where metaphorical frames were realized through multiple metaphorical expressions in Experiment 1 and relatively shorter messages where metaphorical frames were only instantiated through one metaphorical word in Experiment 2.Results The results showed that participants without prior experience with telecom fraud perceived severity as significantly higher in the war-framing condition than in the issue-framing condition. Besides, the framing effects were only detected in Experiment 2 where the short anti-telefraud message with limited metaphorical information was provided.DiscussionThe study reveals that even one metaphorical word is sufficient to build a framework for thinking about complex concepts, like telecom fraud, and prior experience with a certain risk can serve as a moderator of metaphorical framing on people’s risk perceptions. It is also found that the effectiveness of metaphors may be more salient in the genres of a short length such as anti-telefraud banners. The study can shed light on public legal educators whose job is to use effective ways to communicate telecom fraud risk to citizens

The Connecting Method for the Spiral Blades of Concrete Mixer Truck

For the spiral blade of the concrete mixing tank of concrete mixer truck, in order to satisfy the stirring and discharging performance, the installation angle and helix angle of the blade should be assigned according to their segmentation function. Due to the different helix angles and the installation tilt angles, a junction gap of blade is formed at the joint, resulting in the severe silting of discharge or the uneven agitation. We put forward a more reasonable solution by using the MFG (method of fitting gradient) to solve the gap connection of spiral blades. The MFG that can reduce the discharging residual rate of the mixing material has been verified by experiments and applied to actual mass production. We also make the coupling simulation of Multi-Physics Field based on simulation software 17-STARCCM+® to visually verify the scientificity of design and study the complex stresses distribution inside the actual mixing tank. Finally, we provide an up-to-date reference for the design of spiral logarithmic blade, solving the problem of the gap at the traditional spiral-blade connection

Three dimension high definition manometry evaluated postoperative anal canal functions in children with congenital anorectal malformations

BackgroundWe aimed to evaluate the function of the reconstructed anal canal in postoperative anorectal malformations (ARMs) patients through three dimension (3D) high-definition anorectal manometry.MethodsFrom January 2015 to December 2019, 3D manometry was performed as a postoperative functional assessment of patients with ARMs divided into age subgroups based on the time of manometry. Manometric parameters, such as the length of the anorectal high-pressure zone (HPZ-length), the mean resting and squeeze pressure of HPZ (HPZ-rest and HPZ-sqze), recto-anal inhibitory reflex (RAIR), and strength distribution of the anal canal, were collected and compared with age-matched controls. Their functional outcomes were analyzed with SPSS 23.0 software for statistical analysis.Results171 manometric measurements were performed on 142 postoperative patients (3 months∼15 years). The HPZ-rest in all patients was significantly lower than in age-matched controls (p < 0.05). HPZ-sqze was notably decreased in patients older than 4 years, whereas other age groups were comparable to controls (p < 0.05). The proportions of asymmetric strength distribution and negative RAIR were higher in ARMs patients. The type of anorectal malformations and lower HPZ-rest were the impact factors affecting postoperative functional outcomes.ConclusionsThe majority of the ARMs patients had acceptable functional outcomes. 3D manometry can objectively assess the reconstructed anal canal function. The patients with fecal incontinence had a high proportion of extremely low HPZ-rest and HPZ-sqze, negative RAIR, and asymmetric strength distribution. The manometric details will help the clinicians explore the causes of defecation complications and guide further management

Clean power generation from the intractable natural coalfield fires: turn harm into benefit

The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the world, which could generate ~1000GW per annum. A game-changing approach, environmentally sound thermal energy extraction from the intractable natural coalfield fires, is being developed by utilizing the waste energy and reducing the temperature of coalfield fires at the same time. Based on the Seebeck effect of thermoelectric materials, the temperature difference between the heat medium and cooling medium was employed to directly convert thermal energy into clean electrical energy. By the time of December 2016, the power generation from a single borehole at Daquan Lake fire district in Xinjiang has been exceeded 174.6W. The field trial demonstrates that it is possible to exploit and utilize the waste heat resources in the treated coal fire areas. It promises a significant impact on the structure of global energy generation and can also promote progress in thermoelectric conversion materials, geothermal exploration, underground coal fires control and other energy related areas

PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs

© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http://pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species.National Natural Science Foundation of China [32022078]; National Key R&D Program of China [2022YFF1000900]; Local Innovative and Research Teams Project of Guangdong Province [2019BT02N630]; China Agriculture Research System [CARS-35]. Funding for open access charge: National Natural Science Foundation of China [32022078].Peer reviewe

A multicentre single arm phase 2 trial of neoadjuvant pyrotinib and letrozole plus dalpiciclib for triple-positive breast cancer.

peer reviewedCurrent therapies for HER2-positive breast cancer have limited efficacy in patients with triple-positive breast cancer (TPBC). We conduct a multi-center single-arm phase 2 trial to test the efficacy and safety of an oral neoadjuvant therapy with pyrotinib, letrozole and dalpiciclib (a CDK4/6 inhibitor) in patients with treatment-naïve, stage II-III TPBC with a Karnofsky score of ≥70 (NCT04486911). The primary endpoint is the proportion of patients with pathological complete response (pCR) in the breast and axilla. The secondary endpoints include residual cancer burden (RCB)-0 or RCB-I, objective response rate (ORR), breast pCR (bpCR), safety and changes in molecular targets (Ki67) from baseline to surgery. Following 5 cycles of 4-week treatment, the results meet the primary endpoint with a pCR rate of 30.4% (24 of 79; 95% confidence interval (CI), 21.3-41.3). RCB-0/I is 55.7% (95% CI, 44.7-66.1). ORR is 87.4%, (95% CI, 78.1-93.2) and bpCR is 35.4% (95% CI, 25.8-46.5). The mean Ki67 expression reduces from 40.4% at baseline to 17.9% (P < 0.001) at time of surgery. The most frequent grade 3 or 4 adverse events are neutropenia, leukopenia, and diarrhoea. There is no serious adverse event- or treatment-related death. This fully oral, chemotherapy-free, triplet combined therapy has the potential to be an alternative neoadjuvant regimen for patients with TPBC

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery