The current status of mercury repair technology in the environment

In recent years, due to the pollution of heavy metals in the environment, it has brought a serious crisis to my country's ecological balance, especially the pollution of heavy metal mercury (Hg), so the repair of mercury in the environment is crucial. At present, there are many technologies for repairing mercury in the environment. The main repair techniques include physical repair technology and chemical repair technology. However, there are many problems in these two repair methods, such as high repair costs, and it is easy to cause secondary pollution. Microbial repair method is a method of repairing the environment. It can not only adsorb and fix heavy metal mercury, and does not bring pollution to the environment. Therefore, using microorganisms to remove mercury in the environment is by far the most promising environmental repair technology

Easy and Efficient Transformer : Scalable Inference Solution For large NLP model

Recently, large-scale transformer-based models have been proven to be effective over a variety of tasks across many domains. Nevertheless, putting them into production is very expensive, requiring comprehensive optimization techniques to reduce inference costs. This paper introduces a series of transformer inference optimization techniques that are both in algorithm level and hardware level. These techniques include a pre-padding decoding mechanism that improves token parallelism for text generation, and highly optimized kernels designed for very long input length and large hidden size. On this basis, we propose a transformer inference acceleration library -- Easy and Efficient Transformer (EET), which has a significant performance improvement over existing libraries. Compared to Faster Transformer v4.0's implementation for GPT-2 layer on A100, EET achieves a 1.5-4.5x state-of-art speedup varying with different context lengths. EET is available at https://github.com/NetEase-FuXi/EET. A demo video is available at https://youtu.be/22UPcNGcErg

Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy.

ER-derived COPII-coated vesicles are conventionally targeted to the Golgi. However, during cell stress these vesicles also become a membrane source for autophagosomes, distinct organelles that target cellular components for degradation. How the itinerary of COPII vesicles is coordinated on these pathways remains unknown. Phosphorylation of the COPII coat by casein kinase 1 (CK1), Hrr25, contributes to the directional delivery of ER-derived vesicles to the Golgi. CK1 family members are thought to be constitutively active kinases that are regulated through their subcellular localization. Instead, we show here that the Rab GTPase Ypt1/Rab1 binds and activates Hrr25/CK1δ to spatially regulate its kinase activity. Consistent with a role for COPII vesicles and Hrr25 in membrane traffic and autophagosome biogenesis, hrr25 mutants were defective in ER–Golgi traffic and macroautophagy. These studies are likely to serve as a paradigm for how CK1 kinases act in membrane traffic

Liver function indicators and risk of hepatocellular carcinoma: a bidirectional mendelian randomization study

Observational studies have shown an association between liver dysfunction and hepatocellular carcinoma (HCC), but the causality relationship between them is unclear. We aimed to determine whether there is a bidirectional causal relationship between liver function indicators (alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; γ-glutamyltransferase, GGT) and HCC. Our two-sample Mendelian randomization (MR) study acquired single nucleotide polymorphisms (SNPs) associated with liver function indicators (ALT, n = 134,182; AST, n = 134,154; GGT, n = 118,309; ALP, n = 105,030) and with HCC (n = 197,611) from publicly available genome-wide association studies (GWAS) of East Asian ancestry in Japan (BioBank Japan, BBJ). Univariable MR analyses were performed to identify whether the genetic evidence of exposure was significantly associated with outcome. Multivariable MR analysis was conducted to estimate the independent effects of exposures on outcome. Univariable MR analysis indicated that the level of ALT, AST, and GGT was the risk factor for HCC incidence. Meanwhile, multivariable MR analysis revealed that AST was an independent risk factor for HCC. The hazard ratio (HR) of the probability of HCC was 3.045 [95% confidence interval (95%CI), 1.697–5.463, p = 0.003] for AST. The results of reverse MR analyses showed that gene-predictive HCC incidence could increase the levels of AST (HR = 1.031, 95%CI: 1.009–1.054, p = 2.52 × 10−4) and ALT (HR = 1.040, 95%CI: 1.019–1.063, p = 0.005). Meanwhile, HCC may be negatively correlated with ALP levels (HR = 0.971, 95%CI: 0.947–0.995, p = 0.018). This study provides evidence to support that genetically predicted higher levels of AST are related to increased risk of HCC, with no strong evidence of a causal effect of genetically predicted ALP, ALP, and GGT on HCC. In addition, genetic predisposition to HCC could influence blood concentration of ALT, AST, and ALP. Thus, this may create a vicious cycle

CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1

<p>Macroautophagy/autophagy is an important intracellular mechanism for the maintenance of cellular homeostasis. Here we show that the <i>CERKL</i> (ceramide kinase like) gene, a retinal degeneration (RD) pathogenic gene, plays a critical role in regulating autophagy by stabilizing SIRT1. <i>In vitro</i> and <i>in vivo</i>, suppressing CERKL results in impaired autophagy. SIRT1 is one of the main regulators of acetylation/deacetylation in autophagy. In CERKL-depleted retinas and cells, SIRT1 is downregulated. ATG5 and ATG7, 2 essential components of autophagy, show a higher degree of acetylation in CERKL-depleted cells. Overexpression of SIRT1 rescues autophagy in CERKL-depleted cells, whereas CERKL loses its function of regulating autophagy in SIRT1-depleted cells, and overexpression of CERKL upregulates SIRT1. Finally, we show that CERKL directly interacts with SIRT1, and may regulate its phosphorylation at Ser27 to stabilize SIRT1. These results show that CERKL is an important regulator of autophagy and it plays this role by stabilizing the deacetylase SIRT1.</p

Modification and application of sports rehabilitation materials based on conjugated materials

Existing elastic band materials for sports rehabilitation equipment have some deficiencies in strength, flexibility and durability, and need to be further improved. Therefore, the aim of this paper is to modify elastic bands using a conjugated material, carbon nanotubes, to improve the strength, flexibility and durability of elastic bands. In this paper, conjugated carbon nanotubes were prepared, and their elastic bands were strengthened and toughened by solvent, dispersant and functionalizer respectively under tensile testing machine and scanning electron microscope. Then the application effect of elastic band modified by conjugated materials in exercise rehabilitation was analyzed experimentally. The experimental results show that the strength of the elastic bands modified with carbon nanotubes is in the optimal range for sports rehabilitation, and the elongation at break of the test elastic band toughness index was also higher than that before modification, all of which were more than 90%. The recovery time of the elastic band after modification was long; the elastic retention rate was high, and the deformation was not easy. The satisfaction rate of different grades of elastic bands after modification was particularly high, which was not less than 95%. The research and application of elastic band modification based on conjugated material carbon nanotubes is very important for training and treatment in sports rehabilitation, which can provide better support and stability

Evaluating the impact of radiofrequency spectroscopy on reducing reoperations after breast conserving surgery: A meta‐analysis

Abstract Background The benefits of breast conserving surgery for breast cancer patients are well established. To achieve adequate margins of excision, intraoperative management of breast margins is a critical factor through reducing reoperation for inadequate positive margin excision and associated morbidity and cost. Radiofrequency spectroscopy is a technology that could significantly reduce positive margins when used intraoperatively as an adjunct to other margin management methods. Methods A meta‐analysis was completed with 10 publications comparing use of radiofrequency spectroscopy technology (MarginProbe) with standard margin assessment procedures. Three randomized controlled studies and seven retrospective studies comparing MarginProbe to historical controls were included. The primary endpoint was reduction of re‐excision rates. Statistical significance level was set at the two‐sided 5% level corresponding to two‐sided 95% confidence intervals (CIs) of the pooled relative risk estimates. Results A total of 2335 patients from 10 publications were included in this meta‐analysis. The overall relative reduction in re‐excision rate was 0.49 (95% CI: 0.38–0.64, p < 0.001). Statistical methods were used to examine publication bias. Conclusion Despite the limited randomized controlled trials available comparing radiofrequency spectroscopy to standard operation procedures, the data from the 10 studies demonstrate a statistically significant reduction in re‐excision rate of 49% for MarginProbe usage, currently the only technology indicated for intraoperative identification of breast cancer tissue at the lumpectomy specimen margin

The current status of mercury repair technology in the environment

In recent years, due to the pollution of heavy metals in the environment, it has brought a serious crisis to my country's ecological balance, especially the pollution of heavy metal mercury (Hg), so the repair of mercury in the environment is crucial. At present, there are many technologies for repairing mercury in the environment. The main repair techniques include physical repair technology and chemical repair technology. However, there are many problems in these two repair methods, such as high repair costs, and it is easy to cause secondary pollution. Microbial repair method is a method of repairing the environment. It can not only adsorb and fix heavy metal mercury, and does not bring pollution to the environment. Therefore, using microorganisms to remove mercury in the environment is by far the most promising environmental repair technology