USP7: Novel Drug Target in Cancer Therapy

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a catalytically competent state by the C-terminal peptide. Until now, numerous proteins have been identified as substrates of USP7, which play a key role in cell cycle, DNA repair, chromatin remodeling, and epigenetic regulation. Aberrant activation or overexpression of USP7 may promote oncogenesis and viral disease, making it a target for therapeutic intervention. Currently, several synthetic small molecules have been identified as inhibitors of USP7, and applied in the treatment of diverse diseases. Hence, USP7 may be a promising therapeutic target for the treatment of cancer

Analysis and Suppression of Voltage Violation and Fluctuation with Distributed Photovoltaic Integration

In recent years, the violation and fluctuation of system voltage has occurred with greater frequency with the integration of high-penetration distributed photovoltaic generation. In this paper, the voltage violation and fluctuation in a high-penetration distributed photovoltaic integrated system is analyzed, and then a corresponding suppression strategy is proposed. Firstly, based on solar cell and photovoltaic control system models, the influence factors of photovoltaic output are analyzed. Secondly, the voltage violation and fluctuation caused by photovoltaic integration is analyzed, and the quadratic parabola relationship between bus voltage fluctuation and photovoltaic power variation is constructed. Next, according to the virtual synchronous generator characteristic of distributed photovoltaics, a double-hierarchical suppression strategy is proposed to make full use of reactive power regulation capability, which can maintain the symmetry of power supply while meeting standard requirements. The proposed strategy can conveniently realize quick response and support the photovoltaic extensive access. Moreover, with the employment of the proposal, the system voltage violation and fluctuation can be suppressed effectively. Finally, considering the photovoltaic access location, capacity, and partial shading, the effectiveness of the proposed strategy is verified in IEEE 33-bus distribution system with field measured data. After distributed photovoltaic accesses the system, more than 60% of buses appear to have undergone bus voltage violation. With the proposed method, more than 20% of the voltage deviation and more than 6% of the voltage fluctuation are effectively suppressed so that the system voltage can be kept below 1.07 p.u. and the voltage fluctuation can be kept within 4%, meeting the requirements of power quality standards

Schiff Base Compounds as Fluorescent Probes for the Highly Sensitive and Selective Detection of Al³⁺ Ions

Two new Schiff base fluorescent probes (L and S) were designed for selectively detecting Al3+ ions in aqueous medium. Structural characterization of the purely synthesized compounds was acquired by IR, 1H NMR and 13C NMR. Moreover, their photochromic and fluorescent behaviors have been investigated systematically by UV–Vis absorption and fluorescence spectra. The two probes have both high selectivity and sensitivity toward Al3+ ions in aqueous medium. The 2:1 stoichiometry between the Al3+ and probes was verified by Job’s plot. Moreover, the limits of detection (LOD) for Al3+ by L and S were 1.98 × 10−8 and 4.79 × 10−8 mol/L, respectively, which was much lower than most previously reported probes. The possible recognition mechanism was that the metal ions would complex with Schiff base probes because of the prevalence of the species optimal for complex formation, inhibiting the structural isomerization of conjugated double bonds (-C=N-), inhibiting the proton transfer process in the excited state of the molecules and resulting in changes of its color and fluorescence behavior. Furthermore, the probes will have potential applications for selectively, detecting Al3+ ions in the environmental system with high accuracy and providing a new strategy for the design and synthesis of multi-functional sensors

USP7: Novel drug target in cancer therapy

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a catalytically competent state by the C-terminal peptide. Until now, numerous proteins have been identified as substrates of USP7, which play a key role in cell cycle, DNA repair, chromatin remodeling, and epigenetic regulation. Aberrant activation or overexpression of USP7 may promote oncogenesis and viral disease, making it a target for therapeutic intervention. Currently, several synthetic small molecules have been identified as inhibitors of USP7, and applied in the treatment of diverse diseases. Hence, USP7 may be a promising therapeutic target for the treatment of cancer

Research on the Self-Repairing Model of Outliers in Energy Data Based on Regional Convergence

The need for the statistical stability of data is increasing nowadays as the data resource has become a more and more important production factor. In this study, a set of general identification and correction models are established for data outlier modification. The research object we chose is the data of per capita energy consumption. Based on the joint diagnosis method of outliers and the regional convergence theory, the abrupt outliers are identified and corrected. The study finds that there is an outlier in the data of the Ningxia Hui Autonomous Region. According to the club grouping method, 30 provinces in China are divided into two clubs and the Ningxia Hui Autonomous Region is determined to be in the first club. We calculate the convergence rate and obtain the correction results combining the half-life cycle model

Common Variants in <i>LRP2</i> and <i>COMT</i> Genes Affect the Susceptibility of Gout in a Chinese Population

<div><p>Gout is a common inflammation disease resulting from an increase in serum uric acid. Nearly 70% of uric acid is excreted via the kidneys. To date, evidence for an association between genetic loci and gout is absent, equivocal or not replicated. Our study aims to test variants in two genes abundantly expressed in the kidney, <i>LRP2</i> and <i>COMT</i>, for their association with uric acid and gout. In total, 1318 Chinese individuals were genotyped for rs2544390 in <i>LRP2</i> and rs4680 in <i>COMT</i>. These <i>LRP2</i> and <i>COMT</i> gene polymorphisms showed no significant effect on uric acid (<i>P</i> = 0.204 and 0.188, separately); however, rs2544390 in <i>LRP2</i> did influence uric acid levels in individuals with BMI ≥ 25 (<i>P</i> = 0.009). In addition, the allele frequency distributions of the two loci showed a significant difference between gout patients and healthy controls. A missense variation in rs4680 (G > A) decreased the risk of gout (OR = 0.77, <i>P</i> = 0.015), whereas the T allele of rs2544390 was associated with gout pathogenesis risk (OR = 1.26, <i>P</i> = 0.020). The present study provides the first evidence for an association between <i>COMT</i> and gout. Rs2544390 in <i>LRP2</i> only influenced uric acid levels in individuals with BMI ≥ 25, which might explain the discrepant results among previous studies. In addition, we are the first to identify the association between <i>LRP2</i> and gout in a Chinese population and to confirm this association in Asians.</p></div

Odds ratios (ORs) and 95% confidence intervals (CI) from each study about the association of the rs2544390 polymorphism and gout in Asians.

<p>A meta-analysis in fixed-effect model was used to test the association.</p