Cancer-cell microsurgery using nonlinear optical endomicroscopy

Near-infrared laser-based microsurgery is promising for noninvasive cancer treatment. To make it a safe technique, a therapeutic process should be controllable and energy efficient, which requires the cancer cells to be identifiable and observable. In this work, for the first time we use a miniaturized nonlinear optical endomicroscope to achieve microtreatment of cancer cells labeled with gold nanorods. Due to the high two-photon-excited photoluminescence of gold nanorods, HeLa cells inside a tissue phantom up to 250 &mu;m deep can be imaged by the nonlinear optical endomicroscope. This facilitates microsurgery of selected cancer cells by inducing instant damage through the necrosis process, or by stopping cell proliferation through the apoptosis process. The results indicate that a combination of nonlinear endomicroscopy with gold nanoparticles is potentially viable for minimally invasive cancer treatment.<br /

(E)-2-(2H-Benzotriazol-2-yl)-4-methyl-6-(phenyl­imino­meth­yl)phenol

In the title compound, C20H16N4O, the non-H atoms of the benzotriazole ring system and those of the methyl­phenol group are essentially coplanar, with an r.m.s. deviation of 0.004 (2) Å. The mean plane of these atoms forms a dihedral angle of 60.9 (2)° with the phenyl ring. There is an intra­molecular O—H⋯N hydrogen bond between the phenol and benzotriazole groups

Impact of incisions of cataract surgery on patients with corneal astigmatism

AIM: To research the impact of different 3.2mm incisions of cataract surgery on patients whose corneal astigmatism was within 25 degrees by Orbscan. METHODS: We collected 40 cases of cataract patients whose corneal astigmatism was within 25 degrees detected by Orbscan and randomly divided them into groups A, B. Detected by Orbscan, 20 patients(20 eyes)in group A was conducted with 3.2mm corneal astigmatism axial incision and 20 patients(20 eyes)in group B was conducted with 3.2mm corneal incision on 90 degrees of the axis. All cataract operations were implemented by the same physician. We observed the postoperative changes of corneal astigmatism between two groups. RESULTS: The comparisons of Polar K on each time preoperative and postoperative point were significant differences within each group. But the comparisons of Polar K on each time preoperative and postoperative point were not statistically significant between two groups. After 3 months, two kinds of incisions would both increase about 0.3D Polar K in the cornea. CONCLUSION: 3.2mm corneal incision may cause Polar K 0.3D in corneal astigmatism

Serum zinc levels in 368 patients with oral mucosal diseases: a preliminary study

Background: The aim of this study was to assess the serum zinc levels in patients with common oral mucosal diseases by comparing these to healthy controls. Material and Methods: A total of 368 patients, which consisted of 156 recurrent aphthous stomatitis (RAS) patients, 57 oral lichen planus (OLP) patients, 55 burning mouth syndrome (BMS) patients, 54 atrophic glossitis (AG) patients, 46 xerostomia patients, and 115 sex-and age-matched healthy control subjects were enrolled in this study. Serum zinc levels were measured in all participants. Statistical analysis was performed using a one-way ANOVA, t-test, and Chi-square test. Results: The mean serum zinc level in the healthy control group was significantly higher than the levels of all other groups ( p < 0.001). No individual in the healthy control group had a serum zinc level less than the minimum normal value. However, up to 24.7% (13/54) of patients with AG presented with zinc deficiency, while 21.2% (33/156) of patients with RAS, 16.4% (9/55) of patients with BMS, 15.2% (7/46) of patients with xerostomia, and 14.0% (8/57) of patients with OLP were zinc deficient. Altogether, the zinc deficiency rate was 19.02% (70/368) in the oral mucosal diseases (OMD) group (all patients with OMD). The difference between the OMD and healthy control group was significant ( p < 0.001). Gender differences in serum zinc levels were also present, although not statistically significant. Conclusions: Zinc deficiency may be involved in the pathogenesis of common oral mucosal diseases. Zinc supplementation may be a useful treatment for oral mucosal diseases, but this requires further investigation; the optimal serum level of zinc, for the prevention and treatment of oral mucosal diseases, remains to be determined

4-(3-Fluoro­phen­yl)-6-hy­droxy-5-(thio­phen-2-ylcarbon­yl)-6-trifluoro­methyl-1,3-diazinan-2-one

In the title compound, C16H12F4N2O3S, the pyrimidine ring adopts a half-chair conformation; the mean plane formed by the ring atoms excluding the C atom bonded to the thio­phen-2-ylcarbonyl group has an r.m.s. deviation of 0.059 Å. The dihedral angle between the benzene and thio­phene rings is 62.26 (7)°. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯O hydrogen bond, generating an S(6) ring. In the crystal, adjacent mol­ecules are connected via a centrosymmetric R 2 2(6) motif, formed by N—H⋯O hydrogen bonds

Time optimal control based on classification of quantum gates

We study the minimum time to implement an arbitrary two-qubit gate in two heteronuclear spins systems. We give a systematic characterization of two-qubit gates based on the invariants of local equivalence. The quantum gates are classified into four classes, and for each class the analytical formula of the minimum time to implement the quantum gates is explicitly presented. For given quantum gates, by calculating the corresponding invariants one easily obtains the classes to which the quantum gates belong. In particular, we analyze the effect of global phases on the minimum time to implement the gate. Our results present complete solutions to the optimal time problem in implementing an arbitrary two-qubit gate in two heteronuclear spins systems. Detailed examples are given to typical two-qubit gates with or without global phases.Comment: 12 pages, 0 figure