Additional file 1: Figure S1. of Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique

A flowchart for the study population. (TIFF 178 kb

Additional file 2: Table S1. of Association of fibrinogen level with early neurological deterioration among acute ischemic stroke patients with diabetes

Comparison before and after propensity score matching in patients with acute ischemic stroke admitted within 72 h, but without diabetes. Table S2. A logistic regression model for END after propensity score matching in patients without diabetes mellitus admitted within 72 h of acute ischemic stroke. (DOCX 25 kb

Additional file 1: Figure S1. of Association of fibrinogen level with early neurological deterioration among acute ischemic stroke patients with diabetes

A dot plot of standardized mean differences before and after propensity score matching in (A) DM population and (B) non-DM population. (TIFF 261 kb

MOESM1 of Effects of Huang Bai (Phellodendri Cortex) on bone growth and pubertal development in adolescent female rats

Additional file 1. Minimum standards of reporting checklist

The image of woman in Lenka Reinerova's memoirs

The thesis deals with the image of a woman in Lenka Reinerova's memoirs published in Czech. The topic is first showed partially, which means separately for each single memorial prose, chronologically according to a year of their publishing, and afterwards coherently by means of general features included at the beginning of the work. The image of a woman is showed by way of both direct and indirect characterization and comparison. Introductory part of the work is connected wih the Prague Circle and its last member Lenka Reinerová, the last Prague author writing in German. The topic of the Prague Circle and Lenka Reinerova's place in Prague literature written in German as well are envisaged problematically. The aim of the first part of the work is to specify some characterizations which are common for all members of the Prague Circle and to specify Lenka Reinerova's place in Prague German literature more accurately by quoting the contemporary authors writing in German and at the same time related to Prague in the broad sense of the word

Additional file 1: Figure S1. of Development of Stabilized Growth Factor-Loaded Hyaluronate– Collagen Dressing (HCD) matrix for impaired wound healing

The fabrication process of S-EGF and S-bFGF loaded HCD matrix with collagen, HA, and F68. (PDF 42 kb

Clinical profiles of adverse drug reactions spontaneously reported at a single Korean hospital dedicated to children with complex chronic conditions

<div><p>Children with complex chronic conditions (CCC) are presumed to be vulnerable to adverse drug reactions (ADRs). The clinical profiles of ADRs in CCC are not well known. Herein, we aim to describe the ADR profiles in CCC with regard to typical presentations and vulnerable groups. We accessed the ADR yearly reports at a tertiary children's hospital whose practice is mainly dedicated to CCC and descriptively analyzed their clinical profiles according to the presence of a complex chronic condition, ADR severity, and age groups. A total of 1841 cases were analyzed, among which 1258 (68.3%) were mild, 493 (26.8%) moderate, and 90 (4.9%) cases were severe. A total of 1581 (85.9%) cases of complex chronic condition were reported. The proportion of CCC in each severity group increased as the ADR becomes more severe. In CCC, ADRs were most frequently reported by nurses in the adolescent group and in cases where the symptoms involved the gastrointestinal system. The class of antineoplastic and immunomodulating drugs was the most commonly suspected of causing an ADR, followed by one of the antibiotics. When we focus on the trend across the age groups, the ratio of severe-to-total ADRs decreased with older age. Among severe cases, the ratio of off-label prescription-related cases was the highest in the infant/toddler group and decreased as the groups aged. In conclusion, ADRs of CCCs admitted to a tertiary children’s hospital have a unique profile. These groups are vulnerable to ADRs and thus they should be monitored closely, especially when they are infants or toddlers, so that severe ADRs can be identified and treated immediately.</p></div

Photochemically-induced acousto-optics in gases

Acousto-optics consists of launching acoustic waves in a medium (usually a crystal) in order to modulate its refractive index and create a tunable optical grating. In this article, we present the theoretical basis of a new scheme to generate acousto-optics in a gas, where the acoustic waves are initiated by the localized absorption (and thus gas heating) of spatially-modulated UV light, as was demonstrated in Y. Michine and H. Yoneda, Commun. Phys. 3, 24 (2020). We identify the chemical reactions initiated by the absorption of UV light via the photodissociation of ozone molecules present in the gas, and calculate the resulting temperature increase in the gas as a function of space and time. Solving the Euler fluid equations shows that the modulated, isochoric heating initiates a mixed acoustic/entropy wave in the gas, whose high-amplitude density (and thus refractive index) modulation can be used to manipulate a high-power laser. We calculate that diffraction efficiencies near 100 percent can be obtained using only a few millimeters of gas containing a few percent ozone fraction at room temperature, with UV fluences of less than 100 mJ/cm2, consistent with the experimental measurements by Michine and Yoneda. Gases have optics damage thresholds two to three times beyond those of solids; these optical elements should therefore be able to manipulate kJ-class lasers. Our analysis suggest possible ways to optimize the diffraction efficiency by changing the buffer gas composition

Impact of Detoxification Therapy at the Detoxification Center for Children and the Youth in Prague on Current Condition of Selected Clients.

Neonatal peripheral inflammatory pain caused social memory impairment in male juvenile rats. Direct interaction and five-trial social memory tests were performed to clearly reveal the effect of neonatal peripheral inflammatory pain on social memory. A and B. Direct interaction test using the same (A) or different (B) rats in the two trials. A. Both male and female rats in the formalin group displayed increased exploring time (unchanged sociability), but the control group showed decreased exploring time (decreased sociability). * P < 0.05 vs. control; n = 6-7 per group. B. When subject rats were exposed to a novel rat, both groups explored new stimulus rats similarly. * P < 0.05 vs. control; n = 6-7 per group. C. Five-trial social memory assay. Male, but not female, rats in the formalin group dishabituated to the same rat during four trials and habituated to a novel rat (trial 5). * P < 0.05 vs. control; n = 6-7 per group. (TIF 871 kb

The comparison of principal demographic data of patients treated for proximal humeral fractures and humeral dyaphysis fractures

Fractures of proximal humerus and humeral shaft are two clinical problems that have many differences and different treatment. The aim was to compare these differences in a retrospective epidemiological study. At the beginning is an overview of anatomy, classification and treatment of humerus fractures. The point of the study was the evidence of patients, who were treated in Orthopedic - traumatological clinic of FNKV. In years 2000-2008 there were 1891 patients treated for proximal humerus fracture and 223 patients treated for humeral shaft fracture. The result of the work is an overview of incidence, sex and average age of the monitored patients, Neer's and AO classification overview and comparison of surgical and conservative treatment and the progression in time