Joint Link Scheduling and Routing for Load Balancing in STDMA Wireless Mesh Networks

In wireless mesh networks, it is known to be effective to use a TDMA based MAC than a contention-based CSMA. In addition, if spatial TDMA is used, network performance can be improved further because of its spatial reuse effect. However this scheme still has a disadvantage in the system performance aspect without a load-balanced routing because the resource of links that are not used is wasted and frequently used links are out of resources. That is, the number of available flows in network is limited because load balancing is not performed. In this paper, we propose joint link scheduling and routing through a cross-layer scheme. For this, we propose a load balancing routing method to maximize available resources under the given traffic pattern and scheduling method for maximizing link utilization on the given route. These two methods are iterated until an optimized solution can be obtained. The proposed algorithm can be formulated using a mathematical LP problem and we show that it is very effective for load balancing compared to simple adoption of IEEE 802.11s which is a standard TDMA protocol in wireless mesh network. If the proposed algorithm is applied to initial design solution such as Smart Grid, the number of available flows can be increased and the load on each link can be balanced

Fabrication and Evaluation of Mechanical Properties of CF/GNP Composites

AbstractCNT/CFRP (Carbon Nanotube/ Carbon Fiber Reinforced Plastic) composites and GNP/CFRP (Graphene Nano platelet/ Carbon Fiber Reinforced Plastic) have several excellent mechanical properties including, high strength, young's modulus, thermal conductivity, corrosion resistance, electronic shielding and so on. In this study, CNT/CFRP composites were manufactured by varying the CNT weight ratio as 2wt% and 3wt%, While GNP/CFRP composites were manufactured by varying the GNP weight ratio as 0.5wt% and 1wt%. The composites ware manufactured by mechanical method (3-roll-mill). Tensile, impact and wear tests were performed according to ASTM standards D638, D256 and D3181 respectively. It was observed that, increasing the CNT weight ratio improves the mechanical properties, e.g., tensile strength, impact and wear resistance

Characterization of Fabry mice treated with recombinant adeno-associated virus 2/8-mediated gene transfer

<p>Abstract</p> <p>Background</p> <p>Enzyme replacement therapy (ERT) with α-galactosidase A (α-Gal A) is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease. However, ERT has limitations of a short half-life, requirement for frequent administration, and limited efficacy for patients with renal failure. Therefore, we investigated the efficacy of recombinant adeno-associated virus (rAAV) vector-mediated gene therapy for a Fabry disease mouse model and compared it with that of ERT.</p> <p>Methods</p> <p>A pseudotyped rAAV2/8 vector encoding α-Gal A cDNA (rAAV2/8-hAGA) was prepared and injected into 18-week-old male Fabry mice through the tail vein. The α-Gal A expression level and globotriaosylceramide (Gb3) levels in the Fabry mice were examined and compared with Fabry mice with ERT. Immunohistochemical and ultrastructural studies were conducted.</p> <p>Results</p> <p>Treatment of Fabry mice with rAAV2/8-hAGA resulted in the clearance of accumulated Gb3 in tissues such as liver, spleen, kidney, heart, and brain with concomitant elevation of α-Gal A enzyme activity. Enzyme activity was elevated for up to 60 weeks. In addition, expression of the α-Gal A protein was identified in the presence of rAAV2/8-hAGA at 6, 12, and 24 weeks after treatment. α-Gal A activity was significantly higher in the mice treated with rAAV2/8-hAGA than in Fabry mice that received ERT. Along with higher α-Gal A activity in the kidney of the Fabry mice treated with gene therapy, immunohistochemical studies showed more α-Gal A expression in the proximal tubules and glomerulus, and less Gb3 deposition in Fabry mice treated with this gene therapy than in mice given ERT. The α-gal A gene transfer significantly reduced the accumulation of Gb3 in the tubules and podocytes of the kidney. Electron microscopic analysis of the kidneys of Fabry mice also showed that gene therapy was more effective than ERT.</p> <p>Conclusions</p> <p>The rAAV2/8-hAGA mediated α-Gal A gene therapy provided improved efficiency over ERT in the Fabry disease mouse model. Furthermore, rAAV2/8-hAGA-mediated expression showed a greater effect in the kidney than ERT.</p

Serum BDNF levels in patients with gambling disorder are associated with the severity of gambling disorder and Iowa Gambling Task indices

Background and aims Gambling disorder (GD) shares many similarities with substance use disorders (SUDs) in clinical, neurobiological, and neurocognitive features, including decision-making. We evaluated the relationships among, GD, decision-making, and brain-derived neurotrophic factor (BDNF), as measured by serum BDNF levels. Methods Twenty-one male patients with GD and 21 healthy sex- and age-matched control subjects were evaluated for associations between serum BDNF levels and the Problem Gambling Severity Index (PGSI), as well as between serum BDNF levels and Iowa Gambling Task (IGT) indices. Results The mean serum BDNF levels were significantly increased in patients with GD compared to healthy controls. A significant correlation between serum BDNF levels and PGSI scores was found when controlling for age, depression, and duration of GD. A significant negative correlation was obtained between serum BDNF levels and IGT improvement scores. Discussion These findings support the hypothesis that serum BDNF levels constitute a dual biomarker for the neuroendocrine changes and the severity of GD in patients. Serum BDNF level may serve as an indicator of poor decision-making performance and learning processes in GD and help to identify the common physiological underpinnings between GD and SUDs