Zoo-FISH in the European mole (Talpa europaea) detects all ancestral Boreo-Eutherian human homologous chromosome associations

Zoo-FISH with human whole-chromosome paint probes delineated syntenic association of human homologous chromosome segments 3-21, 14-15, 16-19, 4-8, 7-16 and 12-22 (twice) in the European mole (Talpa europaea, Talpidae, Eulipotyphla, Mammalia). These segment associations represent shared ancestral Boreo-Eutherian traits, half of which were previously not described for Eulipotyphla. The karyotype of the European mole acquired a minimum of 19 translocations and six inversions compared to the presumed Boreo-Eutherian ancestor. Copyright (c) 2006 S. Karger AG, Basel

Tests for primordial non-Gaussianity

We investigate the relative sensitivities of several tests for deviations from Gaussianity in the primordial distribution of density perturbations. We consider models for non-Gaussianity that mimic that which comes from inflation as well as that which comes from topological defects. The tests we consider involve the cosmic microwave background (CMB), large-scale structure (LSS), high-redshift galaxies, and the abundances and properties of clusters. We find that the CMB is superior at finding non-Gaussianity in the primordial gravitational potential (as inflation would produce), while observations of high-redshift galaxies are much better suited to find non-Gaussianity that resembles that expected from topological defects. We derive a simple expression that relates the abundance of high-redshift objects in non-Gaussian models to the primordial skewness.Comment: 6 pages, 2 figures, MNRAS in press (minor changes to match the accepted version

GONG p-mode frequency changes with solar activity

We present a correlation analysis of GONG p-mode frequencies with nine solar activity indices for the period 1995 August to 1997 August. This study includes spherical harmonic degree in the range 2 to 150 and the frequency range of 1500-3500 \mu Hz. Using three statistical tests, the measured mean frequency shifts show strong to good correlation with activity indices. A decrease of 0.06 \mu Hz in frequency, during the descending phase of solar cycle 22 and an increase of 0.04 \mu Hz in the ascending phase of solar cycle 23 is observed. These results provide the first evidence for change in p-mode frequencies around the declining phase of solar cycle 22 and beginning of new cycle 23. This analysis further confirms that the temporal behaviour of the solar frequency shifts closely follow the phase of the solar activity cycle.Comment: 14 pages, 3 figures. To appear in Ap.

Electrochemical reduction of carbamazepine in ethanol and water solutions using a glassy carbon electrode

The electrochemical reduction of carbamazepine in ethanol and water using a glassy carbon electrode has been studied. In all experimental conditions of scan rate and concentration of carbamazepine an irreversible cathodic wave was observed by cyclic voltammetry (CV). Electrochemical parameters and a plausible EqC mechanism have been reported from the electrochemical measurements and digital simulation. The values of thermodynamic E1/2 were correlated with solvent polarity parameters that it can be interesting for biological, pharmaceutical and forensic purposes. Limits of Detection (LOD) for DPV are 1.1 and 9.0 g/mL (4.65x10-6 and 3.81x10-5 M) in ethanol and water, respectively. The precision and recoveries obtained for tablets and plasma samples showed that the method could be successfully used for analysis

Tiltrotor CFD part II: aerodynamic optimisation of tiltrotor blades

This paper presents aerodynamic optimisation of tiltrotor blades with high-fidelity computational fluid dynamics. The employed optimisation framework is based on a quasi-Newton method, and the required high-fidelity flow gradients were computed using a discrete adjoint solver. Single-point optimisations were first performed, to highlight the contrasting requirements of the helicopter and aeroplane flight regimes. It is then shown how a trade-off blade design can be obtained using a multi-point optimisation strategy. The parametrisation of the blade shape allowed to modify the twist and chord distributions, and to introduce a swept tip. The work shows how these main blade shape parameters influence the optimal performance of the tiltrotor in helicopter and aeroplane modes, and how a compromise blade shape can increase the overall tiltrotor performance. Moreover, in all the presented cases, the accuracy of the adjoint gradients resulted in a small number of flow evaluations for finding the optimal solution, thus indicating gradient-based optimisation as a viable tool for modern tiltrotor design

X-ray observations of the Compton-thick Seyfert 2 galaxy, NGC 5643

We present results from a ~55 ks long XMM-Newton observation of the obscured AGN, NGC 5643, performed in July 2009. A previous, shorter (about 10 ks) XMM-Newton observation in February 2003 had left two major issues open, the nature of the hard X-ray emission (Compton-thin vs Compton-thick) and of the soft X-ray excess (photoionized vs collisionally ionized matter). The new observation shows that the source is Compton-thick and that the dominant contribution to the soft X-ray emission is by photoionized matter (even if it is still unclear whether collisionally ionized matter may contribute as well). We also studied three bright X-ray sources that are in the field of NGC 5643. The ULX NGC 5643 X-1 was confirmed to be very luminous, even if more than a factor 2 fainter than in 2003. We then provided the first high quality spectrum of the cluster of galaxies Abell 3602. The last source, CXOJ143244.5-442020, is likely an unobscured AGN, possibly belonging to Abell 3602.Comment: 6 pages. Accepted for publication in A&

Non-relativistic Extended Gravity and its applications across different astrophysical scales

Using dimensional analysis techniques we present an extension of Newton's gravitational theory built under the assumption that Milgrom's acceleration constant is a fundamental quantity of nature. The gravitational force converges to Newton's gravity and to a MOND-like description in two different mass and length regimes. It is shown that a modification on the force sector (and not in the dynamical one as MOND does) is more convenient and can reproduce and predict different phenomena usually ascribed to dark matter at the non-relativistic level.Comment: 4 pages, 2 figures. To appear in the proceedings of the 2011 Spanish Relativity Meeting (ERE2011) held in Madrid, Spai

Generative Temporal Models with Spatial Memory for Partially Observed Environments

In model-based reinforcement learning, generative and temporal models of environments can be leveraged to boost agent performance, either by tuning the agent's representations during training or via use as part of an explicit planning mechanism. However, their application in practice has been limited to simplistic environments, due to the difficulty of training such models in larger, potentially partially-observed and 3D environments. In this work we introduce a novel action-conditioned generative model of such challenging environments. The model features a non-parametric spatial memory system in which we store learned, disentangled representations of the environment. Low-dimensional spatial updates are computed using a state-space model that makes use of knowledge on the prior dynamics of the moving agent, and high-dimensional visual observations are modelled with a Variational Auto-Encoder. The result is a scalable architecture capable of performing coherent predictions over hundreds of time steps across a range of partially observed 2D and 3D environments.Comment: ICML 201