Total serum calcium and corrected calcium as severity predictors in acute pancreatitis

AbstractObjectivesTo evaluate total serum calcium (TC) and albumin-corrected calcium (ACC) as prognostic severity factors in acute pancreatitis (AP).MethodsNinety-six patients were included in the study. They were diagnosed with AP and admitted to the Hospital Regional de Veracruz within the time frame of January 2010 to December 2012. AP severity was determined through the updated Atlanta Classification (2013). TC and ACC values were measured in the first 24hours of admittance and the percentages of sensitivity (S), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) were calculated through ROC curves and contingency tables.ResultsIn accordance with the updated Atlanta Classification, 70 patients presented with mild AP, 17 with moderately severe AP, and 9 with severe AP. Of the patient total, 61.5% were women, and 69.8% presented with biliary etiology. The maximum TC cut-off point was 7.5mg/dL, with values of S, 67%; Sp, 82%; PPV, 27%, and NPV, 96%. The maximum ACC cut-off point was 7.5mg/dL, with values of S, 67%; Sp, 90%; PPV, 40%; NPV, 96%. Both had values similar to those of the Ranson and APACHE II prognostic scales.ConclusionsTC and ACC, measured within the first 24hours, are useful severity predictors in acute pancreatitis, with sensitivity and predictive values comparable or superior to those of the conventional prognostic scales

Constraints on the Abundance of PBHs from X-ray Quasar Microlensing Observations: Substellar to Planetary Mass Range

We use X-ray observations of quasar microlensing (sensitive to smaller compact objects than in the optical) to study the possible presence of a population of low mass black holes (from $\sim$ $10^{-3}M_{\odot}$ to $10^{-1}M_{\odot}$) in lens galaxies. We compare these observations with microlensing magnification simulations of a mixed population of stars and black holes (BHs) plus a smooth matter component. We estimate the individual mass fractions of both, stars and BHs, for three different BH masses in the range of substellar to planetary masses. Our Bayesian analysis indicates that the contribution of BHs is negligible in the substellar mass range but that a population of BHs of planetary mass (M $\lesssim$ $10^{-3}M_{\odot}$) could pass unnoticed to X-ray microlensing. We provide new upper limits to the contribution of BHs to the fraction of dark matter based on both, the quasar microlensing data in the X-ray band, and our previous estimates in the optical of intermediate-mass BHs with an additional upper limit at $M=3M_{\odot}$.Comment: 11 pages, 3 figure

Middle Ordovician harknessellid brachiopods (Dalmanellidina) from the Mediterranean margin of Gondwana

The family Harknessellidae Bancroft, 1928 (Orthida, Dalmanellidina) was designed to embrace an assemblage of species referred previously to Harknessella Reed, 1917, and included five genera known mainly from the Middle and Upper Ordovician of England. Herein, we suggest reassigning to this family the genus Cacemia Mitchell, 1974, widespread in the middle Darriwilian (upper Middle Ordovician) of the Iberian and Armorican massifs. Since its designation, Cacemia was placed among the dalmanellidin heterorthids, in spite of its strongly mucronate hinge line, which is totally unknown within this Mediterranean family. A new harknessellid has been identified from the upper Darriwilian beds of the Central Iberian Zone (Central Spain): Isabelella fascicostellata Reyes-Abril Villas gen. et sp. nov. It is similar to Horderleyella Bancroft, 1928 for its coarsely fascicostellate radial ornamentation and obtuse cardinal angles, although its convexoplane to convexoconcave profile allows discrimination from the typically dorsibiconvex Horderleyella. A phylogenetic analysis of the family places both Cacemia and Isabelella in basal positions of their clades, which fits with their early stratigraphic record. Based on our study, the family Harknessellidae appears to have originated in the high latitude Mediterranean margins of Gondwana during pre-Darriwilian times, before the detachment of Avalonia from Gondwana. The family reached its highest diversification in Avalonia throughout the Late Ordovician, keeping connections with the Mediterranean and Proto-Andean margins of Gondwana, as well as with the mid-latitude palaeocontinents of Baltica and South China.Peer Reviewe

Middle Ordovician harknessellid brachiopods (Dalmanellidina) from the Mediterranean margin of Gondwana

The family Harknessellidae Bancroft, 1928 (Orthida, Dalmanellidina) was designed to embrace an assemblage of species referred previously to Harknessella Reed, 1917, and included five genera known mainly from the Middle and Upper Ordovician of England. Herein, we suggest reassigning to this family the genus Cacemia Mitchell, 1974, widespread in the middle Darriwilian (upper Middle Ordovician) of the Iberian and Armorican massifs. Since its designation, Cacemia was placed among the dalmanellidin heterorthids, in spite of its strongly mucronate hinge line, which is totally unknown within this Mediterranean family. A new harknessellid has been identified from the upper Darriwilian beds of the Central Iberian Zone (Central Spain): Isabelella fascicostellata Reyes-Abril Villas gen. et sp. nov. It is similar to Horderleyella Bancroft, 1928 for its coarsely fascicostellate radial ornamentation and obtuse cardinal angles, although its convexoplane to convexoconcave profile allows discrimination from the typically dorsibiconvex Horderleyella. A phylogenetic analysis of the family places both Cacemia and Isabelella in basal positions of their clades, which fits with their early stratigraphic record. Based on our study, the family Harknessellidae appears to have originated in the high latitude Mediterranean margins of Gondwana during pre-Darriwilian times, before the detachment of Avalonia from Gondwana. The family reached its highest diversification in Avalonia throughout the Late Ordovician, keeping connections with the Mediterranean and Proto-Andean margins of Gondwana, as well as with the mid-latitude palaeocontinents of Baltica and South China

Possible Role of Nrf2 in Oxidative and Inflammatory Processes During Menopause

The increase in life expectancy leads to the possibility of development chronic diseases, from special physiological conditions as occurs in the menopause, which is defined as the permanent cessation of ovulation, marked by the end of menstruation. It has been related to decreased ovarian function that occurs around an age of 45 years. This event involves the reduction in estrogen production and may contribute to the development of chronic-degenerative diseases. Many diseases developed during menopause have been associated with oxidative stress, such as osteoporosis, hot flushes, cognitive impairment, insulin resistance, dry skin, obesity, and cardiovascular events. The knowledge about the participation of Nrf2 in diseases that occur during menopause is very limited. Here, only diseases such as osteoporosis, cardiovascular diseases and dry skin, which are present during menopause and its later stages have been described. The Nrf2 pathway involves the participation of PI3K/Akt, MAPK, and eNOS, which act as mediators for cytoprotection and antioxidation. Compounds such as equol, fitoestrogens, alkyl cathecols, or curcumin could be offered as options to antioxidant treatment, added the fact that they are present in fruits and vegetables which are rich in vitamins, minerals and calcium, thus including all the required nutrients for an adequate nutrition

Relating Spatial Quality of Public Transportation and the Most Visited Museums: Revisiting Sustainable Mobility of Waterfronts and Historic Centers in International Cruise Destinations

Museums are main tourist resources for independent cruise passengers in cultural cruise destinations. However, their influence on cruise destinations is scarcely analyzed. The aim of this paper was to focus on two questions: What distribution of museums facilitates a sustainable mobility of cruise tourists in balance with urban needs? And which factors affect the potential use of both means of sustainable travel—soft mobility and public transport—at cruise destinations? The network topological features of main museums were analyzed to compare similar features among tourism destinations. A topological study based on the model of the three urban fabrics was related to the objective quality of PT. This allowed for a greater walkability or potential use of PT to be estimated. The results allowed for a diverse sample of cultural tourism port cities with cruise activity to be classified in three centralized levels and two decentralized ones. Results indicated that centralized networks are more prone to cruise tourists, while decentralized networks are more related to main cultural destinations. Finally, the discussion section analysed recommendations and measures to improve sustainable mobility and the planning of new museums. The results of this paper will be of interest to cultural and transport managers at these types of destinations.This article showcases the results of the “Strategies to recover the public space and residential use over gentrification and touristification in Malaga” research (UMA 20.01), financed by Andalusian Govern for Development, Infrastructures and Spatial Organization. The open access fee is funded by Universidad de Malaga/CBUA

Why and how to assess the quality of research in medicine?

Scientific research is recognized as the main mean resource of science to enrich its capital of knowledge about the surrounding natural and social reality.However, if this activity is not carried out with the required quality, dubious results will be obtained and with them the risk of introducing actions in socialpractice whose validity has not been utterly demonstrated. This is the main justification for the employment of methodological procedures guiding to carryout research with the quality that allows the introduction of results in practice with the essential security. The article approaches the reasons to promote thequality in research work and offers elements on how to appraise it through what is published in scientific journal