Entropy of the Schwarzschild-de Sitter Black Hole due to arbitrary spin fields in different Coordinates

By using the Newman-Penrose formalism and the improved thin-layer ``brick wall'' approach, the statistical-mechanical entropies of the Schwarzschild-de Sitter black hole arising from quantum massless arbitrary spin fields are studied in the Painlev\'e and Lemaitre coordinates. Although the metrics in both the Painlev\'e and the Lemaitre coordinates do not obviously possess the singularities as that in the Schwarzschild-like coordinate, we find that, for arbitrary spin fields, the entropies in the Painlev\'e and Lemaitre coordinates are exactly equivalent to that in the Schwarzschild-like coordinate.Comment: 14 pages, no figure, to be published in JHE

Solvothermal synthesis of uniform bismuth nanospheres using poly(N-vinyl-2-pyrrolidone) as a reducing agent

Uniform bismuth nanospheres were successfully prepared from bismuth nitrate in the presence of poly(N-vinyl-2-pyrrolidone) (PVP) by solvothermal process. The product was characterized by powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, selected area electron diffraction, and energy-dispersive X-ray. PVP plays a critical role both as a reducing agent and a capping agent in the formation of bismuth nanospheres. Shape and size of bismuth nanospheres could be tuned by changing the employed PVP/bismuth salt ratio. It was also found the solvent had an effect on the morphologies of bismuth nanomaterials. The possible formation and growth mechanism of bismuth nanospheres were also discussed and proposed to explain the reduction step

Adaptive Pairwise Encodings for Link Prediction

Link prediction is a common task on graph-structured data that has seen applications in a variety of domains. Classically, hand-crafted heuristics were used for this task. Heuristic measures are chosen such that they correlate well with the underlying factors related to link formation. In recent years, a new class of methods has emerged that combines the advantages of message-passing neural networks (MPNN) and heuristics methods. These methods perform predictions by using the output of an MPNN in conjunction with a "pairwise encoding" that captures the relationship between nodes in the candidate link. They have been shown to achieve strong performance on numerous datasets. However, current pairwise encodings often contain a strong inductive bias, using the same underlying factors to classify all links. This limits the ability of existing methods to learn how to properly classify a variety of different links that may form from different factors. To address this limitation, we propose a new method, LPFormer, which attempts to adaptively learn the pairwise encodings for each link. LPFormer models the link factors via an attention module that learns the pairwise encoding that exists between nodes by modeling multiple factors integral to link prediction. Extensive experiments demonstrate that LPFormer can achieve SOTA performance on numerous datasets while maintaining efficiency

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes

OBJECTIVE—Recent evidence suggests that the AMP-activated protein kinase (AMPK) is an important therapeutic target for diabetes. The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes

Distance-Based Propagation for Efficient Knowledge Graph Reasoning

Knowledge graph completion (KGC) aims to predict unseen edges in knowledge graphs (KGs), resulting in the discovery of new facts. A new class of methods have been proposed to tackle this problem by aggregating path information. These methods have shown tremendous ability in the task of KGC. However they are plagued by efficiency issues. Though there are a few recent attempts to address this through learnable path pruning, they often sacrifice the performance to gain efficiency. In this work, we identify two intrinsic limitations of these methods that affect the efficiency and representation quality. To address the limitations, we introduce a new method, TAGNet, which is able to efficiently propagate information. This is achieved by only aggregating paths in a fixed window for each source-target pair. We demonstrate that the complexity of TAGNet is independent of the number of layers. Extensive experiments demonstrate that TAGNet can cut down on the number of propagated messages by as much as 90% while achieving competitive performance on multiple KG datasets. The code is available at https://github.com/HarryShomer/TAGNet

What kinds of coordinate can keep the Hawking temperature invariant for the static spherically symmetric black hole?

By studying the Hawking radiation of the most general static spherically symmetric black hole arising from scalar and Dirac particles tunnelling, we find the Hawking temperature is invariant in the general coordinate representation (\ref{arbitrary1}), which satisfies two conditions: a) its radial coordinate transformation is regular at the event horizon; and b) there is a time-like Killing vector.Comment: 10 page

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

<p>Ischemic preconditioning (IPC) affords tissue protection in organs including kidneys; however, the underlying mechanism remains unclear. Here we demonstrate an important role of macroautophagy/autophagy (especially mitophagy) in the protective effect of IPC in kidneys. IPC induced autophagy in renal tubular cells in mice and suppressed subsequent renal ischemia-reperfusion injury (IRI). The protective effect of IPC was abolished by pharmacological inhibitors of autophagy and by the ablation of <i>Atg7</i> from kidney proximal tubules. Pretreatment with BECN1/Beclin1 peptide induced autophagy and protected against IRI. These results suggest the dependence of IPC protection on renal autophagy. During IPC, the mitophagy regulator PINK1 (PTEN induced putative kinase 1) was activated. Both IPC and BECN1 peptide enhanced mitolysosome formation during renal IRI in mitophagy reporter mice, suggesting that IPC may protect kidneys by activating mitophagy. We further established an in vitro model of IPC by inducing ‘chemical ischemia’ in kidney proximal tubular cells with carbonyl cyanide 3-chlorophenylhydrazone (CCCP). Brief treatment with CCCP protected against subsequent injury in these cells and the protective effect was abrogated by autophagy inhibition. In vitro IPC increased mitophagosome formation, enhanced the delivery of mitophagosomes to lysosomes, and promoted the clearance of damaged mitochondria during subsequent CCCP treatment. IPC also suppressed mitochondrial depolarization, improved ATP production, and inhibited the generation of reactive oxygen species. Knockdown of <i>Pink1</i> suppressed mitophagy and reduced the cytoprotective effect of IPC. Together, these results suggest that autophagy, especially mitophagy, plays an important role in the protective effect of IPC.</p> <p><b>Abbreviations</b>: ACTB: actin, beta; ATG: autophagy related; BNIP3: BCL2 interacting protein 3; BNIP3L/NIX: BCL2 interacting protein 3 like; BUN: blood urea nitrogen; CASP3: caspase 3; CCCP: carbonyl cyanide 3-chlorophenylhydrazone; COX4I1: cytochrome c oxidase subunit 4I1; COX8: cytochrome c oxidase subunit 8; DAPI: 4ʹ,6-diamidino-2-phenylindole; DNM1L: dynamin 1 like; EGFP: enhanced green fluorescent protein; EM: electron microscopy; ER: endoplasmic reticulum; FC: floxed control; FIS1: fission, mitochondrial 1; FUNDC1: FUN14 domain containing 1; H-E: hematoxylin-eosin; HIF1A: hypoxia inducible factor 1 subunit alpha; HSPD1: heat shock protein family D (Hsp60) member 1; IMMT/MIC60: inner membrane mitochondrial protein; IPC: ischemic preconditioning; I-R: ischemia-reperfusion; IRI: ischemia-reperfusion injury; JC-1: 5,5ʹ,6,6ʹ-tetrachloro-1,1ʹ,3,3ʹ-tetraethylbenzimidazolylcarbocyanine iodide; KO: knockout; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; mito-QC: mito-quality control; mRFP: monomeric red fluorescent protein; NAC: N-acetylcysteine; PINK1: PTEN induced putative kinase 1; PPIB: peptidylprolyl isomerase B; PRKN: parkin RBR E3 ubiquitin protein ligase; ROS: reactive oxygen species; RPTC: rat proximal tubular cells; SD: standard deviation; sIPC: simulated IPC; SQSTM1/p62: sequestosome 1; TOMM20: translocase of outer mitochondrial membrane 20; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling</p

Uniaxial experimental study of the deformation behavior and energy evolution of conjugate jointed rock based on AE and DIC methods

Conjugate joint is one of the most common joint forms in natural rock mass, which is produced by different tectonic movements. To better understand the preexisting flaws, it is necessary to investigate joint development and its effect on the deformation and strength of the rock. In this study, uniaxial compression tests of granite specimens with different conjugate joints distribution were performed using the GAW-2000 compression-testing machine system. The PCI-2 acoustic emission (AE) testing system was used to monitor the acoustic signal characteristics of the jointed specimens during the entire loading process. At the same time, a 3D digital image correlation (DIC) technique was used to study the evolution of stress field before the peak strength at different loading times. Based on the experimental results, the deformation and strength characteristics, AE parameters, damage evolution processes, and energy accumulation and dissipation properties of the conjugate jointed specimens were analyzed. It is considered that these changes were closely related to the angle between the primary and secondary joints. The results show that the AE counts can be used to characterize the damage and failure of the specimen during uniaxial compression. The local stress field evolution process obtained by the DIC can be used to analyze the crack initiation and propagation in the specimen. As the included angle increases from 0° to 90°, the elastic modulus first decreases and then increases, and the accumulative AE counts of the peak first increase and then decrease, while the peak strength does not change distinctly. The cumulative AE counts of the specimen with an included angle of 45° rise in a ladder-like manner, and the granite retains a certain degree of brittle failure characteristics under the axial loading. The total energy, elastic energy, and dissipation energy of the jointed specimens under uniaxial compression failure were significantly reduced. These findings can be regarded as a reference for future studies on the failure mechanism of granite with conjugate joints