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P. Fahriye'nin Hanımlara Mahsus Gazete'de tefrika edilen Dilfikar adlı roman

A study of university library staff management: with particular reference to job satisfaction and motivation issues in Xian Jiaotong University Library of the People's Republic of China

A study of university library staff management: with particular reference to job satisfaction and motivation issues in Xian Jiaotong University Library of the People's Republic of Chin

Mapping spatial variation of population aging in China's mega cities

<p>Based on the statistics of the fifth and sixth censuses in China, this paper, which focuses on the spatial distribution characteristics of aging population in China's mega cities, examines the distribution of aging in Beijing, Shanghai, Guangzhou, and Wuhan. In this paper, an Aging Degree Index and an Aging Population Mean Center have been used to analyze the spatial distribution characteristics and spatial variation trends of aging population in mega cities. According to the research, the spatial distribution of aging population shows a faster development tendency of suburbanization from two different perspectives: one tendency is centrifugal spread associated with seniors who are moving from the city center to outer suburb areas, and the other is center concentration where the seniors who lived in the outer suburb areas are moving towards the city center.</p

Computationally Efficient Estimation for the Generalized Odds Rate Mixture Cure Model With Interval-Censored Data

<p>For semiparametric survival models with interval-censored data and a cure fraction, it is often difficult to derive nonparametric maximum likelihood estimation due to the challenge in maximizing the complex likelihood function. In this article, we propose a computationally efficient EM algorithm, facilitated by a gamma-Poisson data augmentation, for maximum likelihood estimation in a class of generalized odds rate mixture cure (GORMC) models with interval-censored data. The gamma-Poisson data augmentation greatly simplifies the EM estimation and enhances the convergence speed of the EM algorithm. The empirical properties of the proposed method are examined through extensive simulation studies and compared with numerical maximum likelihood estimates. An R package “GORCure” is developed to implement the proposed method and its use is illustrated by an application to the Aerobic Center Longitudinal Study dataset. Supplementary material for this article is available online.</p

Micro Electrochemical pH Sensor Applicable for Real-Time Ratiometric Monitoring of pH Values in Rat Brains

To develop in vivo monitoring meter for pH measurements is still the bottleneck for understanding the role of pH plays in the brain diseases. In this work, a selective and sensitive electrochemical pH meter was developed for real-time ratiometric monitoring of pH in different regions of rat brains upon ischemia. First, 1,2-naphthoquinone (1,2-NQ) was employed and optimized as a selective pH recognition element to establish a 2H⁺/2e^– approach over a wide range of pH from 5.8 to 8.0. The pH meter demonstrated remarkable selectivity toward pH detection against metal ions, amino acids, reactive oxygen species, and other biological species in the brain. Meanwhile, an inner reference, 6-(ferrocenyl)­hexanethiol (FcHT), was selected as a built-in correction to avoid the environmental effect through coimmobilization with 1,2-NQ. In addition, three-dimensional gold nanoleaves were electrodeposited onto the electrode surface to amplify the signal by ∼4.0-fold and the measurement was achieved down to 0.07 pH. Finally, combined with the microelectrode technique, the microelectrochemical pH meter was directly implanted into brain regions including the striatum, hippocampus, and cortex and successfully applied in real-time monitoring of pH values in these regions of brain followed by global cerebral ischemia. The results demonstrated that pH values were estimated to 7.21 ± 0.05, 7.13 ± 0.09, and 7.27 ± 0.06 in the striatum, hippocampus, and cortex in the rat brains, respectively, in normal conditions. However, pH decreased to 6.75 ± 0.07 and 6.52 ± 0.03 in the striatum and hippocampus, upon global cerebral ischemia, while a negligible pH change was obtained in the cortex

Effects of attitude base and affective-cognitive consistency on intergroup instrumental behaviors in Study 2.

<p>This figure was plotted by using the unstandardized regression weights with affective-cognitive consistency along the abscissa at <u>+</u> 1 <i>SD</i> from the mean. Lower affective-cognitive consistency scores signified higher affective-cognitive consistency of group attitudes. Similarly, lower attitude-behavior consistency scores indicated a stronger relation between attitudes and behaviors. Results representing the moderating role of affective-cognitive consistency in the effects of affectively-based and cognitively-based attitudes on intergroup instrumental behaviors show that cognitively-based attitudes predicted intergroup instrumental behaviors more strongly than affectively-based attitudes only when affective-cognitive consistency was high.</p

Effects of attitude base and affective-cognitive consistency on intergroup consummatory behaviors in Study 1.

<p>This figure was plotted by using the unstandardized regression weights with affective-cognitive consistency along the abscissa at <u>+</u> 1 <i>SD</i> from the mean. Lower affective-cognitive consistency scores signified higher affective-cognitive consistency of group attitudes. Similarly, lower attitude-behavior consistency scores indicated a stronger relation between attitudes and behaviors. Results show that affectively-based attitudes predicted intergroup consummatory behaviors more strongly than cognitively-based attitudes regardless of affective-cognitive consistency.</p

What Do the Markets Say? Shareholder Wealth Effects of the XBRL Mandate

We investigate the market reaction to legislative events pertaining to the eXtensible Business Reporting Language (XBRL) mandate. The SEC contends that requiring issuers to adopt XBRL for filing their financial statements would reduce information processing costs and improve market efficiency. In contrast, skeptics argue that the mandatory adoption of XBRL would impose substantial costs while providing few, if any, benefits to investors. Using stock returns from countries that did not mandate the adoption of XBRL to model normal U.S. returns, we provide evidence of a positive market reaction to legislative events related to the XBRL mandate. Moreover, we find that the abnormal returns to these events are increasing for firms with less accessible information, higher information asymmetry, greater information processing costs, and lower financial reporting transparency. Overall, our results suggest an expected net benefit to shareholders from the XBRL mandate

DataSheet_1_miR-939-3p induces sarcoma proliferation and poor prognosis via suppressing BATF2.zip

BackgroundSarcoma is a rare and aggressive malignancy with poor prognosis, in which oncogene activation and tumor suppressor inactivation are involved. Accumulated studies suggested basic leucine zipper transcription factor ATF-like 2 (BATF2) as a candidate tumor suppressor, but its specific role and mechanism in sarcoma remain unclear.MethodsThe expression levels of BATF2 and miR-939-3p were evaluated by using human sarcoma samples, cell lines and xenograft mouse models. Bioinformatics analysis, qPCR, Western blot, cell proliferation assay, overexpression plasmid construction, point mutation and dual luciferase reporter assay were utilized to investigate the role and mechanism of miR-939-3p in sarcoma.ResultsIn this study, we demonstrated that the expression of BATF2 was downregulated in human sarcoma tissues and cell lines. The downregulation of BATF2 was negatively associated with the prognosis of sarcoma patients. Subsequent bioinformatic prediction and experimental validations showed that BATF2 expression was reduced by microRNA (miR)-939-3p mimic and increased by miR-939-3p inhibitor. Additionally, miR-939-3p was upregulated in sarcoma tissues and cells, correlating with a poor prognosis of sarcoma patients. Moreover, miR-939-3p overexpression suppressed sarcoma cell proliferation, which was significantly attenuated by the restoration of BATF2, while siRNA-mediated knockdown of BATF2 aggravated the miR-939-3p-induced promotion of sarcoma cell proliferation. Further computational algorithms and dual-luciferase reporter assays demonstrated that miR-939-3p repressed BATF2 expression via directly binding to its 3’ untranslated region (3’ UTR).ConclusionCollectively, these findings identified miR-939-3p as a novel regulator of BATF2, as well as a prognostic biomarker in sarcoma, and revealed that suppressing miR-939-3p or inducing BATF2 expression may serve as a promising therapeutic strategy against sarcoma.</p

Supplementary document for The Origination of Chiroptical Effect in Plasmonic Nano-Structures in the View of Quasi-Normal Mode Theory - 6832026.pdf

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