Left orderings on inductive limits of amalgamated free products

We study left orderings on countably generated groups. In particular, we construct left orderings of inductive limits of amalgamated free products by using isolated left orderings of the groups appearing in the inductive system. Moreover, we show that they are no longer isolated orderings

Study of Nuclear DNA Content and Chromosomal Numerical Aberrations Using Fluorescence in situ Hybridization in Colorectal Polyps and Colorectal Adenomas

In this study, nuclear DNA content were compared with chromosomal numerical aberration by Fluorescence in situ Hybridization method in 41 cases of colorectal carcinomas and 12 cases of colorectal adenomas. In the adenomas, DNA aneuploidy was shown in 8.3%, and moreover, monosomy of the chromosome 11 was shown in 10% and trisomy of the chromosome 7 was shown in 28.6%. However, no abnormality in the chromosome 17 was defined. In contrast, with regard to the colorectal carcinomas, DNA aneuploidy was shown in 43.9%. Furthermore, it was observed that the rate of appearance of the chromosomal numerical aberrations was high. In the chromosome 17, the rate of appearance of trisomy was significantly higher in DNA aneuploidy cases as compared with DNA diploidy one. However, there was no significant difference in the chromosome 7 and the chromosome 11. In addition, with regard to the colorectal carcinomas in which the chromosome 17 was disomy, there were significantly a large number of cases with positive v factor, and in trisomy cases, there were a lot of cases with negative v factor. In conclusion, it is conceivable that detection of abnormality in chromosomes by FISH method provides a new index of the prognosis and the grade of malignancy in the colorectal carcinomas

Systems genomics of nucleoporins provides prognostic insights into breast cancer

Background: Nucleoporins (Nups) constitute a large group of proteins that are structurally arranged at the nuclear envelope and facilitate the bidirectional movement of molecules across the nuclear membrane. In addition to regulating the shuttling of ribonucleoprotein complexes, RNAs and proteins, various Nups interact with chromatin either directly or indirectly, thus regulating gene expression. Any mutations or expression anomalies of Nups may lead to abnormal localization of critical molecules, or dysregulated expression of genes that they interact with. A comprehensive genomic study encompassing all Nup genes in relation to breast cancer is lacking. Methods: We used genomic and transcriptomic datasets from Pan-Cancer TCGA (The Cancer Genome Atlas), Genotype-Tissue Expression (GTEx) and microarray platforms and conducted in silico analysis of all the genes encoding nucleoporins that are associated with the Nuclear Pore Complexes (NPCs). For mutation detection, we used cBioportal; for expression analysis, we used Xena and for patient survival plots, KMPlot was utilized. Results: The genetic and molecular profile of nucleoporin genes identified multiple mutations and detected aberrant expression in breast cancer. Interestingly, NUP133, AHCTF1, TPR, Nup121L showed simultaneous gene amplification in nearly 10% of breast cancer patients. In addition, deregulated expression of some of the nucleoporins, namely, NUP62, NUP 93, NUP98, NUP155, POM121L12, RAE1, SEC13, TPR were correlated with patient prognosis. Conclusion: The current study is the first one that unravels a comprehensive molecular and genetic profile of nucleoporins genes in breast cancer and underscores the critical roles of various nucleoporins in cancer progression. The identified molecules may advance our understanding of the etiology of the disease and serve as possible targets for novel therapeutic strategies in cancer

人道支援における調整制度の受入れに関する研究 : 「人道支援の改革」におけるクラスター制度を中心に

学位の種別:課程博士University of Tokyo(東京大学

Exploring Community Preparedness for Complex Disaster: A Case Study in Cilegon (Banten Province in Indonesia)

This study aims at examining how local communities in City of Cilegon (Banten province in Indonesia) consider ‘complex disasters’, and clarifying their subjective perceptions. The present research is considered as the first step in our comprehensive research design beyond a specific case study. The nuclear accidents in the GreatEast Japan Earthquake and the huge flood in Thailand provide lessons that natural disasters can cause catastrophic influences on industries and they generate cascading effects and damages. We define such complicated phenomena as ‘complex disasters’ in this article. Cilegon is potentially exposed to such complex disasters because it has natural disaster risks (among others, the Krakatau volcano sits adjacent to it, andrecalling historical earthquakes and tsunami) and industrial disaster risks (a lot of heavy industry facilities including chemical ones), and these two types of risks can be combined and made reality. A ‘model for the communication of risk’ developed by Rodriguez et al. (2007) is adopted as an analytical framework in this study. The model predicts involvement of many types of actors and can be considered as an adequate framework for our study. This study mainly focused on one industrial gas facility of Pertamina, a state-owned energy company, and its surrounding community (Lebak Gede village) in Cilegon. The qualitative methodologies were used in this study: One focused group discussion (FGD) and three key informant interviews were implemented by the authors. The participants of the FGD were twelve leaders of the neighborhood associations (locally described as ‘RT’ and ‘RW’ in Indonesian acronym) closest to the Pertamina facility (two RW leaders and ten RT leaders). The key informant interviews were separately and additionally conducted with a head of a village, a neighborhoodassociation leader (this leader was different from the FGD participants) and a local forum entity, in order to reinforce observations at the FGD. Our survey observed that involvement of the Indonesia Power, a subsidiary of state-owned electricity company whose facilities adjacent to Petamina’s facility, as one of the industry actors, local governmental agencies and the Indonesian Red Cross. On the other hand, we did not clearly identify any clear involvement of the educational institutions and the mass media, although the model of Rodriguez et al. (2007) estimates their engagement. People in Lebak Gede village have already expected potential threats by large-scale natural disasters. Furthermore, they recognize that such disasters give influence on the industrial facilities and the consequences are catastrophic. Although local residents in Lebak Gede village had a lot of experiences of industrial accidents in the past, these experiences did not initiate a significant mindset change for a more organized preparedness. Instead, they paid larger attentions to floods as their preparedness priority. This study adopted the qualitative method for gathering specific information, but more comprehensive research can contribute to verify preparedness and risk perception on the complex disasters. Although this article selectively dealt with one village (Lebak Gede village) and its preparedness and perception, the findings is to be further clarified in detail for generalizing community preparedness for the complex disasters. Keywords: community, risk perception, natural disaster risk, industrial disaster risk, complex disaster, Cilego

Ground Improvement by Dynamic Compaction at a Tailings Disposal Facility

This paper presents two case histories of ground improvement by dynamic compaction (DC) at the Myra Falls mine in Vancouver Island, British Columbia, Canada. Dynamic compaction was employed to densify soils at two sites within the operating mine: a waste rock dump beneath a new processing plant to reduce settlements beneath the structure foundations (Site A); and coarse fluvial and colluvial soils at the toe of an existing tailings embankment to improve seismic resistance against liquefaction (Site B). At Site A, the variable plant loadings required variable compaction energy to achieve uniform foundation performance. At Site B, the foundation soils contained some fine grained soils that dictated a time-controlled sequential DC approach to allow excess pore pressures to dissipate between passes. Because of large uncertainties in the expected performance of DC at both sites, a fair and cost effective DC contract based on unit price per energy was adopted, instead of the traditional performance-based lump sum price contract. This paper describes the ground conditions at the two sites, DC methodologies employed, and ground improvement performance based on measurements of crater volumes and pre- and post-densification in-situ testing by Becker Penetration Tests