Integrated TCGA analysis implicates lncRNA CTB-193M12.5 as a prognostic factor in lung adenocarcinoma

Abstract Background Lung cancer is a malignant tumor with the highest incidence and mortality around the world. Recent advances in RNA sequencing technology have enabled insights into long non-coding RNAs (lncRNAs), a previously largely overlooked species in dissecting lung cancer pathology. Methods In this study, we used a comprehensive bioinformatics analysis strategy to identify lncRNAs closely associated with lung adenocarcinoma, using the RNA sequencing datasets collected from more than 500 lung adenocarcinoma patients and deposited at The Cancer Genome Atlas (TCGA) database. Results Differential expression analysis highlighted lncRNAs CTD-2510F5.4 and CTB-193M12.5, both of which were significantly upregulated in cancerous specimens. Moreover, network analyses showed highly correlated expression levels of both lncRNAs with those of differentially expressed protein-coding genes, and suggested central regulatory roles of both lncRNAs in the gene co-expression network. Importantly, expression of CTB-193M12.5 showed strong negative correlation with patient survival. Conclusions Our study mined existing TCGA datasets for novel factors associated with lung adenocarcinoma, and identified a largely unknown lncRNA as a potential prognostic factor. Further investigation is warranted to characterize the roles and significance of CTB-193M12.5 in lung adenocarcinoma biology

MOESM1 of Integrated TCGA analysis implicates lncRNA CTB-193M12.5 as a prognostic factor in lung adenocarcinoma

Additional file 1: Table S1. CTB-193M12.5 target gene predicted by RIblast

Hydrogenated TiO₂ Nanotube Arrays for Supercapacitors

We report a new and general strategy for improving the capacitive properties of TiO₂ materials for supercapacitors, involving the synthesis of hydrogenated TiO₂ nanotube arrays (NTAs). The hydrogenated TiO₂ (denoted as H–TiO₂) were obtained by calcination of anodized TiO₂ NTAs in hydrogen atmosphere in a range of temperatures between 300 to 600 °C. The H–TiO₂ NTAs prepared at 400 °C yields the largest specific capacitance of 3.24 mF cm^–2 at a scan rate of 100 mV s^–1, which is 40 times higher than the capacitance obtained from air-annealed TiO₂ NTAs at the same conditions. Importantly, H–TiO₂ NTAs also show remarkable rate capability with 68% areal capacitance retained when the scan rate increase from 10 to 1000 mV s^–1, as well as outstanding long-term cycling stability with only 3.1% reduction of initial specific capacitance after 10 000 cycles. The prominent electrochemical capacitive properties of H–TiO₂ are attributed to the enhanced carrier density and increased density of hydroxyl group on TiO₂ surface, as a result of hydrogenation. Furthermore, we demonstrate that H–TiO₂ NTAs is a good scaffold to support MnO₂ nanoparticles. The capacitor electrodes made by electrochemical deposition of MnO₂ nanoparticles on H–TiO₂ NTAs achieve a remarkable specific capacitance of 912 F g^–1 at a scan rate of 10 mV s^–1 (based on the mass of MnO₂). The ability to improve the capacitive properties of TiO₂ electrode materials should open up new opportunities for high-performance supercapacitors

Controllable Synthesis of Zn_<i>x</i>Cd_1–<i>x</i>S@ZnO Core–Shell Nanorods with Enhanced Photocatalytic Activity

We report the synthesis of Zn_<i>x</i>Cd_1–<i>x</i>S@ZnO nanorod arrays via a facile two-step process and the implementation of these core–shell nanorods as an environmental friendly and recyclable photocatalyst for methyl orange degradation. The band gap of Zn_<i>x</i>Cd_1–<i>x</i>S@ZnO core–shell nanorods can be readily tunable by adjusting the ratio of Zn/Cd during the synthesis. These Zn_<i>x</i>Cd_1–<i>x</i>S@ZnO core–shell nanorods exhibit a high photocatalytic activity and good stability in the degradation of the methyl orange. Moreover, these films grown on FTO substrates make the collection and recycle of the photocatalyst easier. These findings may open new opportunities for the design of effective, stable, and easy-recyclable photocatalytic materials