4 research outputs found
Risk-oriented banking supervision: approaches to the assessment of general systemic risks
The last change introduced by the Basel Committee into the Basic principles of banking supervision is their focusing on the assessment and management of banking risks. As we see, banks are at the center of attention of the banking supervision in accordance with the recommendations of the Basel II. However, in our opinion, for the smooth functioning of the economic system more profound problems have to be solved, with the possibilities of banks' bankruptcies and general systemic risks to be addressed. The goal of the article is the development of a conception for the assessment of general economic risks of the banking system as part of a risk-focused banking supervision
Return of the Metabolic Trajectory to the Original Area after Human Bone Marrow Mesenchymal Stem Cell Transplantation for the Treatment of Fulminant Hepatic Failure
Our recent study first demonstrated that human bone marrow
mesenchymal
stem cell (hBMSC) transplantation could prevent death from fulminant
hepatic failure (FHF) in pigs. To further clarify the metabolic mechanism
of hBMSC transplantation in FHF, the plasma collected from FHF pigs
that received transplantation of hBMSCs was examined using metabolic
analysis to identify the key molecular markers that regulate recovery.
The results showed that obvious metabolic disturbance occurred during
FHF, whereas the hBMSC transplantation group showed less severe liver
injury. The metabolic trajectory returns to its original state at
week 3 following the hBMSC transplantation. In total, the concentration
of 26 metabolites, including conjugated bile acids, phosphatidylcholines,
lysophosphatidylcholines, fatty acids, amino acid and sphingomyelin,
are significantly different between the FHF group and the hBMSC transplantation
group. Moreover, the time course of changes in the metabolites corresponded
with that of the biochemical and histological analyses. Real-time
PCR further confirmed that the gene expression of phospholipase A1,
lecithin-cholesterol acyltransferase and lysophosphatidylcholine acyltransferase
1 decreased significantly, whereas that of phospholipase A2 remained
stable, which explains the decrease of the phosphatidylcholines and
lysophosphatidylcholines. These novel results have revealed a metabolic
mechanism for the hBMSC transplantation in FHF, which could lead to
the future development of treatment strategies for stem cell therapies
Return of the Metabolic Trajectory to the Original Area after Human Bone Marrow Mesenchymal Stem Cell Transplantation for the Treatment of Fulminant Hepatic Failure
Our recent study first demonstrated that human bone marrow
mesenchymal
stem cell (hBMSC) transplantation could prevent death from fulminant
hepatic failure (FHF) in pigs. To further clarify the metabolic mechanism
of hBMSC transplantation in FHF, the plasma collected from FHF pigs
that received transplantation of hBMSCs was examined using metabolic
analysis to identify the key molecular markers that regulate recovery.
The results showed that obvious metabolic disturbance occurred during
FHF, whereas the hBMSC transplantation group showed less severe liver
injury. The metabolic trajectory returns to its original state at
week 3 following the hBMSC transplantation. In total, the concentration
of 26 metabolites, including conjugated bile acids, phosphatidylcholines,
lysophosphatidylcholines, fatty acids, amino acid and sphingomyelin,
are significantly different between the FHF group and the hBMSC transplantation
group. Moreover, the time course of changes in the metabolites corresponded
with that of the biochemical and histological analyses. Real-time
PCR further confirmed that the gene expression of phospholipase A1,
lecithin-cholesterol acyltransferase and lysophosphatidylcholine acyltransferase
1 decreased significantly, whereas that of phospholipase A2 remained
stable, which explains the decrease of the phosphatidylcholines and
lysophosphatidylcholines. These novel results have revealed a metabolic
mechanism for the hBMSC transplantation in FHF, which could lead to
the future development of treatment strategies for stem cell therapies
Additional file 1 of Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure
Additional file 1: Table S1. Clinical characteristics of enrolled subjects from the COSSH prospective multicenter cohort. Table S2. Clinical characteristics of ACLF patients in the ELISA validation group from the COSSH prospective multicenter cohort. Table S3. Primers used for real-time PCR. Table S4. Antibodies used for immunoblotting and immunohistochemistry. Table S5. Clinical characteristics of ACLF patients with different THBS1 relative expression in the validation group. Table S6. Clinical characteristics of ACLF patients in the low-risk group and high-risk group of the ELISA validation cohort. Table S7. The enriched biological processes for the top 200 genes which were both differentially expressed in the comparisons of ACLF vs. LC and ACLF vs. NC. Table S8. The immune-related biological processes for top 200 DEGs which were both differentially expressed in the comparisons of ACLF vs. LC and ACLF vs. NC. Table S9. The apoptosis-related biological processes for top 200 DEGs which were both differentially expressed in the comparisons of ACLF vs. LC and ACLF vs. NC