THE EARLY INTERVENTION TENDENCY OF CHINESE CHILDREN WITH COCHLEAR IMPLANTS

From the change of adult unilateral cochlear implantation into young children even under the age of six implant cochlear, sequential bilateral cochlear implantation, which benefit by early hearing screening and technological development of cochlear implants. It is a worldwide trend that simultaneous bilateral cochlear implantation for hearing impaired children under the age of three. Cochlear implants bring changes of education opportunities and choices for children with hearing impairment. Family-centered postoperative early intervention is important, at the same time, hearing impaired children group characteristics tend to be diversified. A growing number of children with cochlear implants study in regular school, consequently, the number of deaf student is decreasing in deaf school. Regular school faces the challenge of lacking of professional teaching staff.

Two-dimensional topological semimetals

The field of two-dimensional topological semimetals, which emerged at the intersection of two-dimensional materials and topological materials, have been rapidly developing in recent years. In this article, we briefly review the progress in this field. Our focus is on the basic concepts and notions, in order to convey a coherent overview of the field. Some material examples are discussed to illustrate the concepts. We discuss the outstanding problems in the field that need to be addressed in future research.Comment: 14 pages, 23 figure

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated dose, which need urgently to be solved. METHODS: The level of cytosolic Ca RESULTS: Here, we demonstrated that TNFα induced extracellular Ca CONCLUSIONS: Our study provides the evidence supporting a novel mechanism by which TNFα induces extracellular C

QTL mapping for haploid male fertility by a segregation distortion method and fine mapping of a key QTL qhmf4 in maize

Doubled haploid (DH) technology enables rapid development of homozygous lines in maize breeding programs. However, haploid genome doubling is a bottleneck for the commercialization of DH technology and is limited by haploid male fertility (HMF). This is the first study reporting the quantitative trait locus (QTL) analysis of HMF in maize. Four QTL, qhmf1, qhmf2, qhmf3, and qhmf4, controlling HMF have been identified by segregation distortion (SD) loci detection in the selected haploid population derived from ‘Yu87-1/Zheng58’. Three loci, qhmf1, qhmf2, and qhmf4, were also detected in the selected haploid population derived from ‘4F1/Zheng58’. The QTL qhmf4 showed the strongest SD in both haploid populations. Based on the sequence information of ‘Yu87-1’ and ‘Zheng58’, thirteen markers being polymorphic between the two lines were developed to saturate the qhmf4 region. A total of 8168 H1BC2 (haploid backcross generation) plants produced from ‘Yu87-1’ and ‘Zheng58’ were screened for recombinants. All the 48 recombinants were backcrossed to ‘Zheng58’ to develop H1BC3 progeny. The heterozygous H1BC3 individuals were crossed with CAU5 to induce haploids. In each H1BC3 progeny, haploids were genotyped and evaluated for anther emergence score (AES). Significant (or no significant) difference (P \u3c 0.05) between haploids with or without ‘Yu87-1’ donor segment indicated presence or absence of qhmf4 in the donor segment. The analysis of the 48 recombinants narrowed the qhmf4 locus down to an ~800 kb interval flanked by markers IND166 and IND1668

An optimized quantum minimum searching algorithm with sure-success probability and its experiment simulation with Cirq

Finding a minimum is an essential part of mathematical models, and it plays an important role in some optimization problems. Durr and Hoyer proposed a quantum searching algorithm (DHA), with a certain probability of success, to achieve quadratic speed than classical ones. In this paper, we propose an optimized quantum minimum searching algorithm with sure-success probability, which utilizes Grover-Long searching to implement the optimal exact searching, and the dynamic strategy to reduce the iterations of our algorithm. Besides, we optimize the oracle circuit to reduce the number of gates by the simplified rules. The performance evaluation including the theoretical success rate and computational complexity shows that our algorithm has higher accuracy and efficiency than DHA algorithm. Finally, a simulation experiment based on Cirq is performed to verify its feasibility.Comment: 15 pages, 8 figures. arXiv admin note: text overlap with arXiv:1908.07943 by other author