Clinical efficacy of radiotherapy combined with sodium glycididazole in the treatment of recurrent oesophageal carcinoma

Purpose: To assess the clinical efficacy and side effects of radiotherapy combined with sodium glycididazole in the treatment of recurrent esophageal carcinoma.Methods: Ninety patients with locally recurrent oesophageal carcinoma who were admitted to the Oncology Department at Taian City Central Hospital, Shandong, China, were randomly divided into a treatment group (treated with radiotherapy and sodium glycididazole) and a control group (treated with radiotherapy alone) in a randomized study. Short-term curative effects, median progression-free survival (PFS), and side effects were compared between the two groups.Results: The cure rate in the treatment group was 86.70 %, whereas that in the control group was 51.10 % (p < 0.05). Median PFS in the treatment group was 9.9 months versus 5.3 months in the control group (p < 0.05). Side effects in both groups included alopecia, headache, nausea, vomiting and leucopaenia, at level one or two. In this regard, the difference between the two groups was statistically insignificant (p > 0.05).Conclusion: Radiotherapy combined with sodium glycididazole shows a higher short-term curative effect in the treatment of recurrent oesophageal carcinoma than radiotherapy alone.Keywords: Alopecia, Leucopaenia, Oesophageal carcinoma, Radiotherapy, Sodium glycididazol

1-(2,6-Difluoro­benzo­yl)-3-(2,3,5-tri­chloro­phen­yl)urea

The asymmetric unit of the title compound, C14H7Cl3F2N2O2, contains two unique molecules. The 2,3,5-trichloro­phenyl ring is almost coplanar with the urea group in both molecules, whereas the 2,6-difluoro­phenyl ring is twisted from the urea plane by 54.83 (10)° in one molecule and 60.58 (10)° in the other. An intra­molecular N—H—O hydrogen bond stabilizes the mol­ecular conformation. The crystal packing is formed by inter­molecular N—H—O hydrogen bonds and F⋯F inter­actions [2.841 (2) Å]

A fault-tolerant triple-redundant voice coil motor for direct drive valves: Design, optimization, and experiment

AbstractA direct drive actuator (DDA) with direct drive valves (DDVs) as the control device is an ideal solution for a flight actuation system. This paper presents a novel triple-redundant voice coil motor (TRVCM) used for redundant DDVs. The TRVCM features electrical/mechanical hybrid triple-redundancy by securing three stators along with three moving coils in the same frame. A permanent magnet (PM) Halbach array is employed in each redundant VCM to simplify the system structure. A back-to-back design between neighborly redundancies is adopted to decouple the magnetic flux linkage. The particle swarm optimization (PSO) method is implemented to optimize design parameters based on the analytical magnetic circuit model. The optimization objective function is defined as the acceleration capacity of the motor to achieve high dynamic performance. The optimal geometric parameters are verified with 3D magnetic field finite element analysis (FEA). A research prototype has been developed for experimental purpose. The experimental results of magnetic field density and force output show that the proposed TRVCM has great potential of applications in DDA systems

Insights into the Ecological Roles and Evolution of Methyl-Coenzyme M Reductase-Containing Hot Spring Archaea

Several recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages. Here, we study the mcr-containing archaeal MAGs from several hot springs, which reveal further expansion in the diversity of archaeal organisms performing methane/alkane metabolism. Significantly, an MAG basal to organisms from the phylum Thaumarchaeota that contains mcr genes, but not those for ammonia oxidation or aerobic metabolism, is identified. Together, our phylogenetic analyses and ancestral state reconstructions suggest a mostly vertical evolution of mcrABG genes among methanogens and methanotrophs, along with frequent horizontal gene transfer of mcr genes between alkanotrophs. Analysis of all mcr-containing archaeal MAGs/genomes suggests a hydrothermal origin for these microorganisms based on optimal growth temperature predictions. These results also suggest methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor

住院老年人误吸风险及对误吸认知的调查分析

Objective:To investigate the aspiration risk and the aspiration cognition of elderly inpatients. Method: A self-designed questionnaire about the aspiration risk and the aspiration cognition was applied to survey the hospitalized elderly. Result: The aspiration risk of the elderly was higher, up to 41.3%, characterized by coming up with various symptoms. The illnesses the elderly suffering from, types of medication, motion ability and the state of consciousness were the risk factors resulting in aspiration (P<0.05); and only 4.4% of the patients completely understood the knowledge of aspiration and aspiration pneumonitis. Conclusion: Elderly patients are at high risk of aspiration along with various symptoms coming up with, and they have poor knowledge about aspiration and aspiration pneumonitis relatively.目的  调查住院老年患者误吸风险及对误吸的认知情况。方法  采用自行设计的误吸风险及误吸认知调查表对住院老年患者进行调查。结果  老年患者误吸风险较高，高达41.3%，且以多种症状同时出现为特点。所患疾病、服药种类、活动能力及意识状态是误吸发生的危险因素（P＜0.05）；仅有4.4%的患者完全了解误吸及吸入性肺炎的知识。结论  老年患者误吸风险高，且以多种症状同时出现为特点，对误吸及吸入性肺炎的知晓率较低

Review of Anaka Dworakowska & Viraktamath, 1975 (Hemiptera, Cicadellidae, Typhlocybinae) with the descriptions of five new species from China

The dikraneurine leafhopper genus Anaka is reviewed based on a comparative morphological study. Five new species, Anaka auricula sp. nov., Anaka cruciata sp. nov., Anaka curvata sp. nov., Anaka rosacea sp. nov., and Anaka spiralis sp. nov. from China are described and illustrated in detail. Additionally, a key to known Anaka species is provided along with a checklist of all species and their distributions