4-(1H-Pyrazol-3-yl)pyridine–terephthalic acid–water (2/1/2)

In the title compound, 2C8H7N3·C8H6O4·2H2O, the pyridine and pyrazole rings are approximately coplanar, the dihedral angle between them being 4.69 (9)°. The asymmetric unit consists of half of the terephthalic acid (an inversion centre generates the other half of the mol­ecule), one 4-(1H-pyrazol-3-yl)pyridine (4pp) mol­ecule and one water mol­ecule. In the crystal, two 4pp and one terephthalic acid mol­ecules form a linear three-molecule unit as a result of O—H⋯N hydrogen bonds. These units are further assembled into a three-dimensional network by two types of hydrogen bonds, viz. O—H⋯O and N—H⋯O

Cooperative Relative Positioning of Mobile Users by Fusing IMU Inertial and UWB Ranging Information

Relative positioning between multiple mobile users is essential for many applications, such as search and rescue in disaster areas or human social interaction. Inertial-measurement unit (IMU) is promising to determine the change of position over short periods of time, but it is very sensitive to error accumulation over long term run. By equipping the mobile users with ranging unit, e.g. ultra-wideband (UWB), it is possible to achieve accurate relative positioning by trilateration-based approaches. As compared to vision or laser-based sensors, the UWB does not need to be with in line-of-sight and provides accurate distance estimation. However, UWB does not provide any bearing information and the communication range is limited, thus UWB alone cannot determine the user location without any ambiguity. In this paper, we propose an approach to combine IMU inertial and UWB ranging measurement for relative positioning between multiple mobile users without the knowledge of the infrastructure. We incorporate the UWB and the IMU measurement into a probabilistic-based framework, which allows to cooperatively position a group of mobile users and recover from positioning failures. We have conducted extensive experiments to demonstrate the benefits of incorporating IMU inertial and UWB ranging measurements.Comment: accepted by ICRA 201

catena-Poly[[(acetato-κO)[4-(1H-pyrazol-3-yl)pyridine-κN 1]zinc]-μ-acetato-κ2 O:O′]

In the title compound, [Zn(CH3CO2)2(C8H7N3)]n, the ZnII atom is coordinated by one N atom from a 4-(1H-pyrazol-3-yl)pyridine ligand and three O atoms from two bridging and one terminal acetate ligands, forming a distorted tetra­hedral geometry. The bridging acetate ligands link the Zn atoms into a chain along [001]. N—H⋯O hydrogen bonds and π–π inter­actions between the pyridine and pyrazole rings [centroid–centroid distance = 3.927 (3) Å] connect the chains into a layer parallel to (011)

Dichloridobis[4-(1H-pyrazol-3-yl)pyridine-κN 1]zinc

In the title compound, [ZnCl2(C8H7N3)2], the ZnII cation is coordinated by two Cl− anions and two 4-(1H-pyrazol-3-yl)pyridine ligands in a distorted tetra­hedral geometry. In the two 4-(1H-pyrazol-3-yl)pyridine ligands, the dihedral angles between the pyrazole and pyridine rings are 3.3 (3) and 13.3 (3)°. Inter­molecular N—H⋯N and N—H⋯Cl hydrogen bonding is present in the crystal structure

An evolutionary algorithm with double-level archives for multiobjective optimization

Existing multiobjective evolutionary algorithms (MOEAs) tackle a multiobjective problem either as a whole or as several decomposed single-objective sub-problems. Though the problem decomposition approach generally converges faster through optimizing all the sub-problems simultaneously, there are two issues not fully addressed, i.e., distribution of solutions often depends on a priori problem decomposition, and the lack of population diversity among sub-problems. In this paper, a MOEA with double-level archives is developed. The algorithm takes advantages of both the multiobjective-problemlevel and the sub-problem-level approaches by introducing two types of archives, i.e., the global archive and the sub-archive. In each generation, self-reproduction with the global archive and cross-reproduction between the global archive and sub-archives both breed new individuals. The global archive and sub-archives communicate through cross-reproduction, and are updated using the reproduced individuals. Such a framework thus retains fast convergence, and at the same time handles solution distribution along Pareto front (PF) with scalability. To test the performance of the proposed algorithm, experiments are conducted on both the widely used benchmarks and a set of truly disconnected problems. The results verify that, compared with state-of-the-art MOEAs, the proposed algorithm offers competitive advantages in distance to the PF, solution coverage, and search speed

Depth-resolved rhodopsin molecular contrast imaging for functional assessment of photoreceptors

Rhodopsin, the light-sensing molecule in the outer segments of rod photoreceptors, is responsible for converting light into neuronal signals in a process known as phototransduction. Rhodopsin is thus a functional biomarker for rod photoreceptors. Here we report a novel technology based on visible-light optical coherence tomography (VIS-OCT) for in vivo molecular imaging of rhodopsin. The depth resolution of OCT allows the visualization of the location where the change of optical absorption occurs and provides a potentially accurate assessment of rhodopsin content by segmentation of the image at the location. Rhodopsin OCT can be used to quantitatively image rhodopsin distribution and thus assess the distribution of functional rod photoreceptors in the retina. Rhodopsin OCT can bring significant impact into ophthalmic clinics by providing a tool for the diagnosis and severity assessment of a variety of retinal conditions

Health-related quality of life and health preference of Chinese patients with diabetes mellitus managed in primary care and secondary care setting: decrements associated with individual complication and number of complications

Background: Health-related quality of life (HRQoL) and health preference of patients with diabetes mellitus (DM) are essential in health economic evaluations but data on Chinese population is rare. This study aims to evaluate HRQoL and health preference of diabetic patients with different diabetic complications in Chinese population. Methods: A cross-sectional study was conducted in 1275 patients with DM, including 518 subjects with various DM-related complications. HRQoL and health preference were estimated using SF-12 and SF-6D questionnaires, respectively. Disease status of DM and complications were identified from documented clinical diagnosis. Multivariable regression was used to investigate the effects of specific complications on HRQoL and health preference, adjusting for socio-demographic and clinical parameters. Results: The presence of any diabetic complication was associated with lower physical component summary (−3.81 points, P < 0.01), and end-stage renal disease (ESRD) showed greatest reduction (−7.05 points, P < 0.01). Mental component summary and mental health (MH) scores were not decreased in any of the diabetic complications. The health preference score for diabetic subjects without complications was 0.882 (95% CI, 0.778 to 0.989). The reductions of health preference score were significant for stroke (−0.042, 95% CI -0.072 to −0.012), ESRD (−0.055, 95% CI -0.093 to −0.017), and sight-threatening diabetic retinopathy (STDR) (−0.043, 95% CI -0.075 to −0.010), while heart disease had an insignificant reduction (−0.017, 95% CI -0.042 to 0.008). Conclusions: The presence of any of the four major diabetic complications (heart disease, stroke, ESRD and STDR) was associated with lower HRQoL and health preference scores. Findings of this study facilitated the cost-effectiveness studies of alternative management strategies for prevention of diabetic complications in Chinese population.published_or_final_versio

Directive local color transfer based on dynamic look-up table

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