Laser field strength dependence of solid high-harmonic generation from doped systems

We have theoretically studied the field-strength dependent high-harmonic generation (HHG) in doped systems like nano-size or bulk materials. Our results show when the amplitude of the vector potential A_peak of the driving laser reaches the half-width of the Brillouin zone ({\pi}/a0), the harmonic yield of the undoped systems is larger than the doped systems. The band-climbing process enhances the interband transition of HHG for higher conduction bands. When A_peak is below {\pi}/a0 , the harmonic yield of the doped systems is stronger than the undoped systems. The atomic doping density also influences the field-strength dependent spectra.Comment: 10 page

NETWORK DEVICE SYSTEM LOGGING SUMMARIZATION BASED ON LOW-RANK ADAPTATION AND CONTRASTIVE LEARNING

Techniques are presented herein that support the automatic generation of refined and summarized text from a system logging (syslog) message sequence. Aspects of the presented techniques employ an abstractive syslog summarization large language model (LLM) that is trained with contrastive learning and then fine-tuned using a Low-Rank Adaptation (LoRA) methodology. Under further aspects of the presented techniques, auxiliary text (such as network incident reports and application incident reports) is added to the prompt of the input of the LLM model to help the model generate a richer syslog summarization

Long-term inhibition of kindled seizures by brain stimulation

It was concluded from previous studies that prior stimulation produced a long-lasting inhibition of kindled seizures only when a series of convulsions were evoked. The present study describes a brain stimulation procedure capable of producing a long-lasting inhibition of kindled convulsions without evoking prior convulsions of EEG afterdischarge. Electrodes were implanted in the amygdala of rats, which were then kindled to a criterion of five successive tonic-clonic convulsions. After kindling, the animals were exposed to a regimen of intermittent amygdala stimulation, which was gradually increased in intensity in small incremental steps from a point just below the convulsion threshold to an intensity above the original kindling current. Using this procedure, it proved possible to administer high stimulation intensities without evoking any behavioral convulsions or EEG afterdischarges. Subsequent to this inhibitory procedure, amygdala stimulation did not evoke convulsions or EEG seizures for as long as 7 days. Additional studies tested the relative effectiveness of different stimulation rggimens and parameters for producing long-lasting inhibition of kindled seizures. The magnitude of the incremental intensity steps, the interstimulus interval, and the intensity of stimulation all proved to be relevent. We concluded that long-lasting inhibition of kindled seizures could be produced by prior stimulation that did not evoke seizures.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24000/1/0000249.pd

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.

BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury. However, whether Hsp70 interacts with p38 MAPK signaling is unclear. Therefore, this study investigated the regulation of p38 MAPK by Hsp70 in I/R-induced cardiac injury.MethodsNeonatal rat cardiomyocytes were subjected to oxygen-glucose deprivation for 6 h followed by 2 h reoxygenation (OGD/R), and rats underwent left anterior artery ligation for 30 min followed by 30 min of reperfusion. The p38 MAPK inhibitor (SB203580), Hsp70 inhibitor (Quercetin), and Hsp70 short hairpin RNA (shRNA) were used prior to OGD/R or I/R. Cell viability, lactate dehydrogenase (LDH) release, serum cardiac troponin I (cTnI), [Ca2+]i levels, cell apoptosis, myocardial infarct size, mRNA level of IL-1β and IL-6, and protein expression of Hsp70, phosphorylated p38 MAPK (p-p38 MAPK), sarcoplasmic/endoplasmic reticulum Ca2+-ATPase2 (SERCA2), phosphorylated signal transducer and activator of transcription3 (p-STAT3), and cleaved caspase3 were assessed.ResultsPretreatment with a p38 MAPK inhibitor, SB203580, significantly attenuated OGD/R-induced cell injury or I/R-induced myocardial injury, as evidenced by improved cell viability and lower LDH release, resulted in lower serum cTnI and myocardial infarct size, alleviation of [Ca2+]i overload and cell apoptosis, inhibition of IL-1β and IL-6, and modulation of protein expressions of p-p38 MAPK, SERCA2, p-STAT3, and cleaved-caspase3. Knockdown of Hsp70 by shRNA exacerbated OGD/R-induced cell injury, which was effectively abolished by SB203580. Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin.ConclusionsInhibition of Hsp70 aggravates [Ca2+]i overload, inflammation, and apoptosis through regulating p38 MAPK signaling during cardiac I/R injury, which may help provide novel insight into cardioprotective strategies

GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis

Background: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to discussion. Our previous investigations have shown that GGPPS1 plays a critical role during hyperinsulinism. In this report, the expression and distribution of GGPPS1 in liver cancer, and its clinical significance were investigated. Methods: 70 patients with hepatocellular carcinoma (HCC) were included in this study. Three different types of tissues from each HCC patient were assembled immediately after surgical resection: tumor-free tissue >5 cm far from tumor edge (TF), adjacent nonmalignant tissue within 2 cm (AT), and tissue from the tumor (TT). Normal liver tissues from 10 liver transplant donors served as healthy control (HC) while 10 patients with liver cirrhosis as cirrhosis control (CC). The expression and distribution of GGPPS1 were detected by immunohistochemistry, western blots, or real-time PCR. The relationship between the expression of GGPPS1 and clinic pathologic index were analyzed. Results: We found that GGPPS1 was intensified mainly in the cytoplasm of liver tumor cells. Both the expression of GGPPS1 mRNA and protein were upregulated in TT comparing to AT or TF. Meanwhile, HCC patients with cirrhosis had relative higher expression of GGPPS1. In addition, many pathologic characters show close correlation with GGPPS1, such as tumor stage, vessel invasion, and early recurrence. Conclusion: GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC

Improved oxidation resistance of high emissivity coatings on fibrous ceramic for reusable space systems

To develop high emissivity coatings on fibrous ceramic substrates with improved thermal resistance for reusable space systems, WSi2–MoSi2–Si–SiB6-borosilicate glass coatings were prepared on fibrous ZrO2 by slurry dipping and subsequent high temperature rapid sintering. A coating with 20 wt% WSi2 and 50 wt% MoSi2 presents optimal thermal stability with only 10.06 mg/cm2 mass loss and 4.0% emissivity decrease in the wavelength regime 1.27–1.73 μm after 50 h oxidation at 1773 K. The advantages of double phase metal-silicide coatings combining WSi2 and MoSi2 include improved thermal compatibility with the substrate and an enhanced glass-mediated self-healing ability