Study on teaching methods for engineering project management based on professional accreditation of engineering programs

This article is focused on the teaching methodology for Engineering Project Management course. The course is an elementary and core course for automotive engineering major based on the requirement of professional accreditation of engineering programs. The course can be described as a course with big scale and more emphasized on industry. Three teaching methodologies have been used to coordinating with the course features: case-study learning, mission-driven learning, project-driven learning and flipped-classroom learning. The article addressed how the three methods have been applied in teaching. Meanwhile, the article also mentioned that a multi-methods evaluation should be more precise for evaluating students’ abilities

Preventive and (Neo)Adjuvant Therapeutic Effects of Metformin on Cancer

Metformin, the first-line antidiabetic drug, has become an attractive candidate in cancer therapy since retrospective clinical investigations reported that patients with type 2 diabetes receiving metformin had lower incidence of cancer than those with other glucose lowering drugs. In line with this, preclinical studies have demonstrated that the antitumor activity of metformin could proceed through several mechanisms. Thus far, metformin has been used in cancer prevention with reduced risk as consequence and treatment of various cancers as an adjuvant or neoadjuvant drug. Thus, existing data support the beneficial effects of metformin on many types of cancers such as reducing metastasis and mortality and improving pathological responses and survival rates. However, some reports do not support this and even show adverse effects. The discrepancy may be attributed to expression levels of its transporters or genetic background. Hence, this chapter briefly reviews information on the mechanism of metformin action and summarizes both completed and ongoing clinical trials in an attempt to evaluate the value of metformin in prevention and treatment of various cancer types

Quantum measurement characteristics of double-dot single electron transistor

Owing to a few unique advantages, double-dot single electron transistor has been proposed as an alternative detector for charge states. In this work, we present a further study for its signal-to-noise property, based on a full analysis of the setup configuration symmetry. It is found that the effectiveness of the double-dot detector can approach that of an ideal detector, if the symmetric capacitive coupling is taken into account. The quantum measurement efficiency is also analyzed, by comparing the measurement time with the measurement-induced dephasing time.Comment: 7 pages, 5 figure

Local climate change and the impacts on hydrological processes in an arid alpine catchment in Karakoram

Climate change and the impacts on hydrological processes in Karakoram region are highly important to the available water resources in downstream oases. In this study, a modified quantile perturbation method (QPM), which was improved by considering the frequency changes in different precipitation intensity ranges, and the Delta method were used to extract signals of change in precipitation and temperature, respectively. Using a historical period (1986-2005) for reference, an average ensemble of 18 available Global Circulation Models (GCMs) indicated that the annual precipitation will increase by 2.9-4.4% under Representative Concentration Pathway 4.5 (RCP4.5) and by 2.8-7.9% in RCP8.5 in different future periods (2020-2039, 2040-2059, 2060-2079 and 2080-2099) due to an increased intensity of extreme precipitation events in winter. Compared with the historical period, the average ensemble also indicated that temperature in future periods will increase by 0.31-0.38 degrees C/10a under RCP4.5 and by 0.34-0.58 degrees C/10a under RCP8.5. Through coupling with a well-calibrated MIKE SHE model, the simulations suggested that, under the climate change scenarios, increasing evaporation dissipation will lead to decreased snow storage in the higher altitude mountain region and likewise with regard to available water in the downstream region. Snow storage will vary among elevation bands, e.g., the permanent snowpack area below 5600 m will completely vanish over the period 2060-2079, and snow storage in 5600-6400 m will be reduced dramatically; however, little or no change will occur in the region above 6400 m. Warming could cause stronger spring and early summer stream runoff and reduced late summer flow due to a change in the temporal distribution of snowmelt. Furthermore, both the frequency and intensity of flooding will be enhanced. All the changes in hydrological processes are stronger under RCP8.5 than those under RCP4.5. In Karakoram region, the transformations among different forms of water resources alter the distributions of hydrologic components under future climate scenarios, and more studies are needed on the transient water resources system and the worsening of flood threats in the study area

Regional differences and sources of organochlorine pesticides in soils surrounding chemical industrial parks

Concentrations of organochlorine pesticides (OCPs; dichlorodiphenyltrichloroethanes (DDTs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB)) were investigated in 105 soil samples collected in vicinity of the chemical industrial parks in Tianjin, China. OCP concentrations significantly varied in the study area, high HCH and DDT levels were found close to the chemical industrial parks. The intensity of agricultural activity and distance from the potential OCP emitters have important influences on the OCP residue distributions. Principal component analysis indicates that HCH pollution is a mix of historical technical HCH and current lindane pollution and DDT pollution input is only due to technical DDT sources. The significant correlations of OCP compounds reveal that HCHs, DDTs and HCB could have some similar sources of origin