Compound dark tea ameliorates obesity and hepatic steatosis and modulates the gut microbiota in mice

Dark tea is a fermented tea that plays a role in regulating the homeostasis of intestinal microorganisms. Previous studies have found that dark tea can improve obesity and has a lipid-lowering effect. In this study, green tea, Ilex latifolia Thunb (kuding tea) and Momordica grosvenori (Luo Han Guo) were added to a new compound dark tea (CDT), to improve the taste and health of this beverage. High-fat diet-fed C57BL/6J mice were treated with low- (6 mg/mL) or high- (12 mg/mL) concentrations of CDT for 18 weeks to assess their effect on lipid metabolism. Our results suggest that low- and high-concentrations of CDT could reduce body weight by 15 and 16% and by 44 and 38% of body fat, respectively, by attenuating body weight gain and fat accumulation, improving glucose tolerance, alleviating metabolic endotoxemia, and regulating the mRNA expression levels of lipid metabolism-related genes. In addition, low concentrations of CDT were able to reduce the abundance of Desulfovibrio, which is positively associated with obesity, and increase the abundance of Ruminococcus, which are negatively associated with obesity. This study demonstrates the effect of CDT on ameliorating lipid metabolism and provides new insights into the research and development of functional tea beverages

Somatic SF3B1 hotspot mutation in prolactinomas.

The genetic basis and corresponding clinical relevance of prolactinomas remain poorly understood. Here, we perform whole genome sequencing (WGS) on 21 patients with prolactinomas to detect somatic mutations and then validate the mutations with digital polymerase chain reaction (PCR) analysis of tissue samples from 227 prolactinomas. We identify the same hotspot somatic mutation in splicing factor 3 subunit B1 (SF3B1R625H) in 19.8% of prolactinomas. These patients with mutant prolactinomas display higher prolactin (PRL) levels (p = 0.02) and shorter progression-free survival (PFS) (p = 0.02) compared to patients without the mutation. Moreover, we identify that the SF3B1R625H mutation causes aberrant splicing of estrogen related receptor gamma (ESRRG), which results in stronger binding of pituitary-specific positive transcription factor 1 (Pit-1), leading to excessive PRL secretion. Thus our study validates an important mutation and elucidates a potential mechanism underlying the pathogenesis of prolactinomas that may lead to the development of targeted therapeutics

Search for the decay J/ψ→γ+invisibleJ/\psi\to\gamma + \rm {invisible}

We search for $J/\psi$ radiative decays into a weakly interacting neutral particle, namely an invisible particle, using the $J/\psi$ produced through the process $\psi(3686)\to\pi^+\pi^-J/\psi$ in a data sample of $(448.1\pm2.9)\times 10^6$ $\psi(3686)$ decays collected by the BESIII detector at BEPCII. No significant signal is observed. Using a modified frequentist method, upper limits on the branching fractions are set under different assumptions of invisible particle masses up to 1.2 $\mathrm{\ Ge\kern -0.1em V}/c^2$. The upper limit corresponding to an invisible particle with zero mass is 7.0$\times 10^{-7}$ at the 90\% confidence level

Search for Λˉ\bar{\Lambda}-Λ\Lambda oscillations in the decay J/ψ→pK−Λˉ+c.c.J/\psi \to p K^- \bar{\Lambda}+c.c.

We report the first search for $\bar\Lambda$--$\Lambda$ oscillations in the decay $J/\psi \to p K^- \bar{\Lambda} + c.c.$ by analyzing $1.31\times10^9$ $J/\psi$ events accumulated with the BESIII detector at the BEPCII collider. The $J/\psi$ events are produced using $e^+e^-$ collisions at a center of mass energy $\sqrt{s}= 3.097$~GeV. No evidence for hyperon oscillations is observed. The upper limit for the oscillation rate of $\bar\Lambda$ to $\Lambda$ hyperons is determined to be $\mathcal{P}(\Lambda)=\frac{\mathcal{B}(J/\psi\to pK^-\Lambda+c.c.)}{\mathcal{B}(J/\psi\to pK^-\bar\Lambda+c.c.)}<4.4\times10^{-6}$ corresponding to an oscillation parameter $\delta m_{\Lambda\bar\Lambda}$ of less than $3.8\times10^{-18}$~GeV at the 90\% confidence level.Comment: 7 pages, 1 figur

Amplitude analysis of Ds+→π+π−π+D_s^{+} \rightarrow \pi^{+} \pi^{-} \pi^{+}

Utilizing the data set corresponding to an integrated luminosity of $3.19$ fb$^{-1}$ collected by the BESIII detector at a center-of-mass energy of 4.178 GeV, we perform an amplitude analysis of the $D_s^+\to\pi^+\pi^-\pi^+$ decay. The sample contains 13,797 candidates with a signal purity of $\sim$80%. The amplitude and phase of the contributing $\pi\pi$ ${\cal S}$ wave are measured based on a quasi-model-independent approach, along with the amplitudes and phases of the ${\cal P}$ and ${\cal D}$ waves parametrized by Breit-Wigner models. The fit fractions of different intermediate decay channels are also reported.Comment: 14 pages, 6 figure

Observation of J/ψJ/\psi decays to e+e−e+e−e^{+}e^{-}e^{+}e^{-} and e+e−μ+μ−e^{+}e^{-}\mu^{+}\mu^{-}

Using a data sample of $4.481\times 10^8$ $\psi(3686)$ events collected with the BESIII detector, we report the first observation of the four-lepton-decays $J/\psi\to e^+e^-e^+e^-$ and $J/\psi\to e^+e^-\mu^+\mu^-$ utilizing the process $\psi(3686)\to \pi^+\pi^- J/\psi$. The branching fractions are determined to be $[4.32\pm0.26~(\rm stat)\pm0.19~(\rm syst)]\times 10^{-5}$ and $[2.45~\pm0.21~(\rm stat)\pm0.10~(\rm syst)]\times 10^{-5}$, respectively. The results deviate from theoretical predictions, by 2.8 and 5.2 $\sigma$, respectively. No significant signal is observed for $J/\psi\to \mu^+\mu^-\mu^+\mu^-$, and an upper limit on the branching fraction is set at $1.6\times 10^{-6}$ at the 90$\%$ confidence level. A CP asymmetry observable is constructed for the first two channels, which is measured to be $(-0.019\pm0.067\pm0.025)$ and $(-0.016\pm0.081\pm0.003)$, respectively. No evidence for CP violation is observed in this process.Comment: 9 pages, 1 figur

Amplitude analysis and branching fraction measurement of the decay \boldmath Ds+→K+π+π−π0D_{s}^{+} \to K^+\pi^{+}\pi^{-}\pi^{0}

The singly Cabibbo-suppressed decay $D_{s}^{+} \to K^+\pi^{+}\pi^{-}\pi^{0}$ is observed, using a data set corresponding to an integrated luminosity of 6.32 $\rm fb^{-1}$ recorded by the BESIII detector at the centre-of-mass energies between 4.178 and 4.226 GeV. The first amplitude analysis of $D_{s}^{+} \to K^+\pi^{+}\pi^{-}\pi^{0}$ reveals the sub-structures in this decay and determines the fractions and relative phases of different intermediate processes. The dominant intermediate process is $D_s^+ \to K^{*0}\rho^+$, with a fit fraction of $(40.5\pm2.8_{\rm{stat.}}\pm1.5_{\rm{syst.}})\%$. With the detection efficiency based on our amplitude analysis, the absolute branching fraction for $D_{s}^{+} \to K^+\pi^{+}\pi^{-}\pi^{0}$ is measured to be $(9.75\pm0.54_{\rm{stat.}}\pm0.17_{\rm{syst.}})\times 10^{-3}$

Observation of the Y(4230)Y(4230) and evidence for a new vector charmonium-like state Y(4710)Y(4710) in e+e−→KS0KS0J/ψe^{+}e^{-}\to K_{S}^{0} K_{S}^{0} J/\psi

Cross sections for the process $e^{+} e^{-} \to K_{S}^{0} K_{S}^{0} J/\psi$ at center-of-mass energies from $4.128$ to $4.950$ GeV are measured using data samples with a total integrated luminosity of 21.2 fb$^{-1}$ collected by the BESIII detector operating at the BEPCII storage ring. The $Y(4230)$ state is observed in the energy dependence of the $e^{+} e^{-} \to K_{S}^{0} K_{S}^{0} J/\psi$ cross section for the first time with a statistical significance of 26.0$\sigma$. In addition, an enhancement around $4.710$ GeV, called the $Y(4710)$, is seen with a statistical significance of 4.2$\sigma$. There is no clear structure around $4.484$ GeV. Using a fit with a coherent sum of three Breit-Wigner functions, we determine the mass and width of the $Y(4230)$ state to be $4226.9 \pm 6.6 \pm 21.9$ MeV/$c^{2}$ and $71.7 \pm 16.2 \pm 31.4$ MeV, respectively, and the mass and width of the $Y(4710)$ state to be $4704.0 \pm 52.3 \pm 69.5$ MeV/$c^{2}$ and $183.2 \pm 114.0 \pm 90.8$ MeV, respectively, where the first uncertainties are statistical and the second are systematic. In addition, the average Born cross section ratio of $e^{+} e^{-} \to K_{S}^{0} K_{S}^{0} J/\psi$ to $e^{+} e^{-} \to K^{+} K^{-} J/\psi$ is measured to be $0.388_{-0.028}^{+0.035}\pm0.016$, or $0.426_{-0.031}^{+0.038}\pm0.018$ if three-body phase space is considered.Comment: Update draft based the comments from PRD refere

Observation of χcJ→ΛΛˉη\chi_{cJ}\to \Lambda\bar \Lambda \eta

By analyzing $(448.1\pm2.9)\times10^6$ $\psi(3686)$ events collected with the BESIII detector operating at the BEPCII collider, the decays of $\chi_{cJ} \to \Lambda\bar \Lambda \eta$ ($J=0$, 1 and 2) are observed for the first time with statistical significances of $13.9\sigma$, $6.7\sigma$, and $8.2\sigma$, respectively. The product branching fractions of $\psi(3686)\to\gamma\chi_{cJ}$ and $\chi_{cJ}\to \Lambda\bar \Lambda \eta$ are measured. Dividing by the world averages of the branching fractions of $\psi(3686)\to\gamma\chi_{cJ}$, the branching fractions of $\chi_{cJ}\to \Lambda\bar \Lambda \eta$ decays are determined to be $(2.31\pm0.30\pm0.21)\times10^{-4}$, $(5.86\pm1.38\pm0.68)\times10^{-5}$, and $(1.05\pm0.21\pm0.15)\times10^{-4}$ for $J=0$, 1 and 2, respectively, where the first uncertainties are statistical and the second systematic.Comment: 9 pages, 4 figure