Badania nad poprawą wyników małych i mikroprzedsiębiorstw poprzez stosowanie zielonych innowacji

It is an important goal of China’s 2025 Strategy to build an environmental governance system with the government as the leading role, enterprises as the main body, and social organizations and the public all participate actively. In this context, whether and how small and micro enterprises, as a force of rejuvenating the country through science and technology, participate in the construction of environmental governance system is discussed in this paper. This study uses the 12th China small and micro enterprise survey database to deeply analyze the direct and indirect effects between green innovation and small and micro enterprise performance, and finds that: in the direct effect analysis, the direct promotion effect of green innovation on the financial performance of small and micro enterprises is related to the development stage of small and micro enterprises, which is significant in the initial stage and mature stage, but not significant in the growth stage; in the indirect effect analysis, green innovation can indirectly improve the overall performance of small and micro enterprises by improving their environmental and social responsibility performance. At the same time, green innovation can amplify the role of other factors in promoting the overall performance. This study not only enriches the research scope of green innovation theory from the subdivision dimension, provides a new perspective for the integration of green innovation and social responsibility theory, it also provides theoretical reference and guidance for the green innovation practice of small and micro enterprises.Ważnym celem chińskiej Strategii 2025 jest zbudowanie systemu zarządzania środowiskowego, z rządem odgrywającym wiodącą rolę, przedsiębiorstwami jako głównym organem  i aktywnie uczestniczącymi organizacjami społecznymi i społeczeństwem. W niniejszym artykule omówiono, czy i w jaki sposób małe i mikroprzedsiębiorstwa, uczestniczą w budowie systemu zarządzania środowiskiem. W badaniu wykorzystano 12. bazę danych ankietowych małych i mikroprzedsiębiorstw w Chinach, aby dogłębnie przeanalizować bezpośrednie i pośrednie zależności między zielonymi innowacjami a wynikami małych i mikroprzedsiębiorstw. Stwierdzono, że: w analizie skutków bezpośrednich bezpośredni wpływ promocji zielonych innowacji na finanse wyniki małych i mikroprzedsiębiorstw jest związany z fazą rozwoju małych i mikroprzedsiębiorstw, jest ona istotna w fazie początkowej i dojrzałej, ale nieistotna w fazie wzrostu; w analizie skutków pośrednich zielone innowacje mogą pośrednio poprawić ogólne wyniki małych i mikroprzedsiębiorstw poprzez poprawę ich wyników w zakresie odpowiedzialności środowiskowej i społecznej. Jednocześnie ekologiczne innowacje mogą wzmocnić rolę innych czynników w promowaniu ogólnej wydajności. Niniejszy artykuł nie tylko wzbogaca zakres badawczy teorii zielonych innowacji z wymiaru podpodziałowego, zapewnia nową perspektywę integracji zielonych innowacji i teorii odpowiedzialności społecznej, ale także dostarcza teoretycznego odniesienia i wskazówek dla praktyki zielonych innowacji małych i mikroprzedsiębiorstw

Badanie wskaźnika zielonej konkurencyjności przemysłu wytwórczego w aglomeracji miejskiej delty rzeki Jangcy

From the perspective of the complex multi-factors that affect manufacturing green competitiveness, this study constructs a green competitiveness index measurement indicator system of manufacturing industry in Yangtze River Delta Urban Agglomeration, which includes five dimensions: economic creativity, technological innovation, energy and environmental protection, industrial structure optimization, and social service capabilities. The manufacturing green competitiveness index in Yangtze River Delta Urban Agglomeration in 2014-2018 is measured and analyzed by using the comprehensive evaluation model of gray correlation projection method based on the combined weights of FAHP and maximum deviation. The results show that manufacturing green competitiveness of Yangtze River Delta Urban Agglomeration generally shows a relatively stable and continuous improvement trend, but the regional differences are large: regional cities and general node cities have significantly lower manufacturing green competitiveness than the leading cities and hub cities, and the pace of industrial structure transformation and upgrading in the whole region also needs to be accelerated. Based on these results, this paper puts forward some policy recommendations for comprehensive development of Yangtze River Delta Urban Agglomeration manufacturing industry: focus on improving the effective guidance of the positive incentive effect of technological innovation on manufacturing green competitiveness level, and solving the problem of insufficient technological innovation achievement transformation benefits; replan regional space, strengthen the integration of all industrial resources, reducing homogeneous competition; strengthen the ecological co-construction of regional manufacturing and improve social service security level.Z perspektywy złożonych czynników, które wpływają na konkurencyjność ekologiczną produkcji, w niniejszym artykule opracowano system pomiaru wskaźnika konkurencyjności ekologicznej dla przemysłu wytwórczego w aglomeracji miejskiej w delcie rzeki Jangcy. Obejmuje on pięć wymiarów: kreatywność ekonomiczną, innowacje technologiczne, energię i ochronę środowiska, optymalizację struktury przemysłowej i zakres usług społecznych. Wskaźnik konkurencyjności ekologicznej produkcji w aglomeracji miejskiej delty rzeki Jangcy w latach 2014-2018 jest mierzony i analizowany za pomocą kompleksowego modelu oceny metodą projekcji szarej korelacji opartej na połączonych wagach FAHP i maksymalnym odchyleniu. Wyniki pokazują, że konkurencyjność produkcji ekologicznej w aglomeracji miejskiej delty rzeki Jangcy na ogół wykazuje względnie stabilną i ciągłą tendencję do poprawy, ale różnice regionalne są duże: miasta regionalne i główne miasta węzłowe mają znacznie niższą konkurencyjność ekologiczną w zakresie produkcji niż miasta wiodące i miasta centralne, a tempo transformacji i modernizacji struktury przemysłowej w całym regionie również wymaga przyspieszenia. W oparciu o te wyniki, w niniejszym artykule przedstawiono pewne zalecenia polityczne dotyczące wszechstronnego rozwoju przemysłu wytwórczego w aglomeracji miejskiej delty rzeki Jangcy: skupiono się na sformułowaniu skutecznych wskazówek dotyczących pozytywnego efektu zachęty ze strony innowacji technologicznych na poziom konkurencyjności produkcji ekologicznej oraz na rozwiązaniu problemu niewystarczającej korzyści z transformacji osiągnięć innowacji technologicznych; należy przebudować przestrzeń regionalną, wzmocnić integrację wszystkich zasobów przemysłowych, zmniejszając jednorodną konkurencję; wzmocnić ekologiczne współtworzenie regionalnej produkcji i poprawić poziom zabezpieczenia społecznego

Rethinking pulmonary toxicity in advanced non-small cell lung cancer in the era of combining anti-PD-1/PD-L1 therapy with thoracic radiotherapy.

The combination of programmed cell death 1/programmed cell death ligand 1 blockade and thoracic radiotherapy has become the new standard of care in the treatment of locally advanced non-small-cell lung cancer. The information regarding the pulmonary safety of such therapy remains limited to mostly retrospective studies and case reports with a small portion of data from prospective clinical trials. By analyzing the underlying mechanisms of interactions between radiation and immunotherapy from preclinical data and summarizing safety data from relevant clinical studies with pulmonary toxicity, we believe that longer and rigorous follow-up is warranted, to determine if the combination of such modalities is appropriate for patients without risking undue toxicity

Therapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments

A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author’s publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.Wear debris associated periprosthetic osteolysis represents a major pathological process associated with the aseptic loosening of joint prostheses. Naringin is a major flavonoid identified in grapefruit. Studies have shown that naringin possesses many pharmacological properties including effects on bone metabolism. The current study evaluated the influence of naringin on wear debris induced osteoclastic bone resorption both in vitro and in vivo. The osteoclast precursor cell line RAW 264.7 was cultured and stimulated with polymethylmethacrylate (PMMA) particles followed by treatment with naringin at several doses. Tartrate resistant acid phosphatase (TRAP), calcium release, and gene expression profiles of TRAP, cathepsin K, and receptor activator of nuclear factor-kappa B were sequentially evaluated. PMMA challenged murine air pouch and the load bearing tibia titanium pin-implantation mouse models were used to evaluate the effects of naringin in controlling PMMA induced bone resorption. Histological analyses and biomechanical pullout tests were performed following the animal experimentation. The in vitro data clearly demonstrated the inhibitory effects of naringin in PMMA induced osteoclastogenesis. The naringin dose of 10 µg/mL exhibited the most significant influence on the suppression of TRAP activities. Naringin treatment also markedly decreased calcium release in the stimulated cell culture medium. The short-term air pouch mouse study revealed that local injection of naringin ameliorated the PMMA induced inflammatory tissue response and subsequent bone resorption. The long-term tibia pin-implantation mouse model study suggested that daily oral gavage of naringin at 300 mg/kg dosage for 30 days significantly alleviated the periprosthetic bone resorption. A significant increase of periprosthetic bone volume and regaining of the pin stability were found in naringin treated mice. Overall, this study suggests that naringin may serve as a potential therapeutic agent to treat wear debris associated osteolysis

Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes

AbstractThe papillomavirus E2 protein tethers viral genomes to host mitotic chromosomes to ensure genome maintenance. We have identified the bromodomain protein Brd4 as a major cellular interacting partner of the bovine papillomavirus E2. Brd4 associates with mitotic chromosomes and colocalizes with E2 on mitotic chromosomes. The site of E2 binding maps to the C-terminal domain of Brd4. Expression of this C-terminal Brd4 domain functions in a dominant-negative manner to abrogate the colocalization of E2 with Brd4 on mitotic chromosomes, to block association of the viral episomes with Brd4, and to inhibit BPV-1 DNA-mediated cellular transformation. Brd4 also associates with HPV16 E2, indicating that Brd4 binding may be a shared property of all papillomavirus E2 proteins. The interaction of E2 with Brd4 is required to ensure the tethering of viral genomes to the host mitotic chromosomes for persistence of viral episomes in PV-infected cells

Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes.

The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but the molecular mechanism(s) coordinating relaxin expression in the heart remain largely obscured. Previous work demonstrated a role for the orphan nuclear receptor Nur77 in regulating cardiomyocyte apoptosis. We therefore investigated Nur77 in the hopes of identifying novel relaxin regulators. Quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) data indicated that ectopic expression of orphan nuclear receptor Nur77 markedly increased the expression of latexin-3 (RLN3), but not relaxin-1 (RLN1), in neonatal rat ventricular cardiomyocytes (NRVMs). Furthermore, we found that the -adrenergic agonist isoproterenol (ISO) markedly stimulated RLN3 expression, and this stimulation was significantly attenuated in Nur77 knockdown cardiomyocytes and Nur77 knockout hearts. We showed that Nur77 significantly increased RLN3 promoter activity via specific binding to the RLN3 promoter, as demonstrated by electrophoretic mobility shift assay (EMSA) and chromatin immuno-precipitation (ChIP) assays. Furthermore, we found that Nur77 overexpression potently inhibited ISO-induced cardiomyocyte apoptosis, whereas this protective effect was significantly attenuated in RLN3 knockdown cardiomyocytes, suggesting that Nur77-induced RLN3 expression is an important mediator for the suppression of cardiomyocyte apoptosis. These findings show that Nur77 regulates RLN3 expression, therefore suppressing apoptosis in the heart, and suggest that activation of Nur77 may represent a useful therapeutic strategy for inhibition of cardiac fibrosis and heart failure. © 2018 You et al

Primary Tumor Standardized Uptake Value Measured on F18-Fluorodeoxyglucose Positron Emission Tomography Is of Prediction Value for Survival and Local Control in Non–Small-Cell Lung Cancer Receiving Radiotherapy: Meta-Analysis

Introduction:The 2-[18F]-Fluorodeoxyglucose (FDG) positron emission tomography (PET/CT) has become an imaging tool for clinical assessment of tumor, node, metastasis in non–small-cell lung cancer (NSCLC). Primary tumor maximum standardized uptake value (SUVmax) on 18F-FDG PET/CT before and after radiation therapy (RT) has been studied as a potential prognostic factor for NSCLC patients receiving radiotherapy. However, the sample sizes of most studies were small, and the results of the prediction value of SUVmax remained undetermined, which lead us to perform a meta-analysis to improve the precision in estimating its effect.Methods:We performed a meta-analysis of published literature for primary tumor SUVmax-based biomarkers of the outcome of NSCLC receiving radiotherapy. The required data for estimation of individual hazard ratios (HRs) to compare patients with a low and a high SUVmax were extracted from each publication. A combined HR was calculated by Stata statistical software (Version 11). All of the results were verified by two persons to ensure its accuracy.Results:Thirteen studies were finally included into this meta-analysis; data are available in 13 studies for pre-RT primary tumor SUVmax and in five studies for post-RT. For overall survival, the combined HR estimate was 1.05 (95% confidence interval [CI], 1.02–1.08) and 1.32 (95% CI, 1.15–1.51) for pre-RT SUVmax and post-RT SUVmax, respectively; 1.26 (95% CI, 1.05–1.52) and 2.01 (95% CI, 1.16–3.46) for local control (LC). In stereotactic body radiotherapy (SBRT) group, HR for LC was 1.11 (95% CI, 1.06–1.18) and 2.19 (95% CI, 1.34–3.60) for pre-SBRT SUVmax and post-SBRT SUVmax, respectively.Conclusion:Both pre-RT and post-RT primary tumor SUVmax can predict the outcome of patients with NSCLC treated with radiotherapy. Patients with high levels of pre-RT SUVmax seemed to have poorer overall survival and LC