2-Chloro-N-{5-[(4R,5R,10S)-dehydro­abiet-4-yl]-1,3,4-thia­diazol-2-yl}benzamide

There are two independent mol­ecules in the asymmetric unit of the title compound, C28H32ClN3OS (systematic name: 2-chloro-N-{5-[(1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octa­hydro­phenanthren-1-yl]-1,3,4-thia­diazol-2-yl}benzamide). In each mol­ecule, the cyclo­hexyl ring attached to the thia­diazole fragment adopts a classic chair conformation with two of its two methyl groups in the axial positions. In the crystal, pairs of inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into centrosymmetric dimers, which are further linked via C—H⋯π inter­actions

Research Report on the Effect of Network Teaching Mode of Art Courses under the Concept of Ideological and Political Education

 Since the National Conference on ideological and political work in Colleges and Universities, the Party Committee of Beijing United University has closely focused on the fundamental problem of “what kind of person to train, how to train and for whom to train”, and regards the course of ideological and political thinking as the fundamental measure to carry out the fundamental task of building up people by virtue. In 2020, in the event of the new epidemic situation, the school actively implemented the work plan of “stopping classes and not stopping learning” in Beijing, and opened the historic revolution of the whole school network teaching in education and teaching.In recent years, Beijing Union University in the “curriculum ideological and political” construction is constantly open up. In order to promote teaching practice and teaching research, the school teacher teaching development center set up the first teaching promoters of Beijing United University in 2019. The project team was set up by the school teaching promoters to study the effect of the online teaching mode of art courses under the concept of ideological and political education

Controllable 3D Face Generation with Conditional Style Code Diffusion

Generating photorealistic 3D faces from given conditions is a challenging task. Existing methods often rely on time-consuming one-by-one optimization approaches, which are not efficient for modeling the same distribution content, e.g., faces. Additionally, an ideal controllable 3D face generation model should consider both facial attributes and expressions. Thus we propose a novel approach called TEx-Face(TExt & Expression-to-Face) that addresses these challenges by dividing the task into three components, i.e., 3D GAN Inversion, Conditional Style Code Diffusion, and 3D Face Decoding. For 3D GAN inversion, we introduce two methods which aim to enhance the representation of style codes and alleviate 3D inconsistencies. Furthermore, we design a style code denoiser to incorporate multiple conditions into the style code and propose a data augmentation strategy to address the issue of insufficient paired visual-language data. Extensive experiments conducted on FFHQ, CelebA-HQ, and CelebA-Dialog demonstrate the promising performance of our TEx-Face in achieving the efficient and controllable generation of photorealistic 3D faces. The code will be available at https://github.com/sxl142/TEx-Face.Comment: Accepted by AAAI 202

Multistate analysis of multitype recurrent event and failure time data with event feedbacks in biomarkers

From Wiley via Jisc Publications RouterHistory: received 2020-04-07, rev-recd 2021-04-19, accepted 2021-06-05, pub-electronic 2021-07-13Article version: VoRPublication status: PublishedAbstract: In this paper we propose a class of multistate models for the analysis of multitype recurrent event and failure time data when there are past event feedbacks in longitudinal biomarkers. It can well incorporate various effects, including time‐dependent and time‐independent effects, of different event paths or the number of occurrences of events of different types. Asymptotic unbiased estimating equations based on polynomial splines approximation are developed. The consistency and asymptotic normality of the proposed estimators are provided. Simulation studies show that the naive estimators which either ignore the past event feedback or the measurement errors are biased. Our method has a better coverage probability of the time‐varying/constant coefficients, compared to the naive methods. An application to the dataset from the Atherosclerosis Risk in Communities Study, which is also the motivating example to develop the method, is presented

TransHuman: A Transformer-based Human Representation for Generalizable Neural Human Rendering

In this paper, we focus on the task of generalizable neural human rendering which trains conditional Neural Radiance Fields (NeRF) from multi-view videos of different characters. To handle the dynamic human motion, previous methods have primarily used a SparseConvNet (SPC)-based human representation to process the painted SMPL. However, such SPC-based representation i) optimizes under the volatile observation space which leads to the pose-misalignment between training and inference stages, and ii) lacks the global relationships among human parts that is critical for handling the incomplete painted SMPL. Tackling these issues, we present a brand-new framework named TransHuman, which learns the painted SMPL under the canonical space and captures the global relationships between human parts with transformers. Specifically, TransHuman is mainly composed of Transformer-based Human Encoding (TransHE), Deformable Partial Radiance Fields (DPaRF), and Fine-grained Detail Integration (FDI). TransHE first processes the painted SMPL under the canonical space via transformers for capturing the global relationships between human parts. Then, DPaRF binds each output token with a deformable radiance field for encoding the query point under the observation space. Finally, the FDI is employed to further integrate fine-grained information from reference images. Extensive experiments on ZJU-MoCap and H36M show that our TransHuman achieves a significantly new state-of-the-art performance with high efficiency. Project page: https://pansanity666.github.io/TransHuman/Comment: Accepted by ICCV 202

Free-style and Fast 3D Portrait Synthesis

Efficiently generating a free-style 3D portrait with high quality and consistency is a promising yet challenging task. The portrait styles generated by most existing methods are usually restricted by their 3D generators, which are learned in specific facial datasets, such as FFHQ. To get a free-style 3D portrait, one can build a large-scale multi-style database to retrain the 3D generator, or use a off-the-shelf tool to do the style translation. However, the former is time-consuming due to data collection and training process, the latter may destroy the multi-view consistency. To tackle this problem, we propose a fast 3D portrait synthesis framework in this paper, which enable one to use text prompts to specify styles. Specifically, for a given portrait style, we first leverage two generative priors, a 3D-aware GAN generator (EG3D) and a text-guided image editor (Ip2p), to quickly construct a few-shot training set, where the inference process of Ip2p is optimized to make editing more stable. Then we replace original triplane generator of EG3D with a Image-to-Triplane (I2T) module for two purposes: 1) getting rid of the style constraints of pre-trained EG3D by fine-tuning I2T on the few-shot dataset; 2) improving training efficiency by fixing all parts of EG3D except I2T. Furthermore, we construct a multi-style and multi-identity 3D portrait database to demonstrate the scalability and generalization of our method. Experimental results show that our method is capable of synthesizing high-quality 3D portraits with specified styles in a few minutes, outperforming the state-of-the-art.Comment: project website: https://tianxiangma.github.io/FF3

Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes.

The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but the molecular mechanism(s) coordinating relaxin expression in the heart remain largely obscured. Previous work demonstrated a role for the orphan nuclear receptor Nur77 in regulating cardiomyocyte apoptosis. We therefore investigated Nur77 in the hopes of identifying novel relaxin regulators. Quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) data indicated that ectopic expression of orphan nuclear receptor Nur77 markedly increased the expression of latexin-3 (RLN3), but not relaxin-1 (RLN1), in neonatal rat ventricular cardiomyocytes (NRVMs). Furthermore, we found that the -adrenergic agonist isoproterenol (ISO) markedly stimulated RLN3 expression, and this stimulation was significantly attenuated in Nur77 knockdown cardiomyocytes and Nur77 knockout hearts. We showed that Nur77 significantly increased RLN3 promoter activity via specific binding to the RLN3 promoter, as demonstrated by electrophoretic mobility shift assay (EMSA) and chromatin immuno-precipitation (ChIP) assays. Furthermore, we found that Nur77 overexpression potently inhibited ISO-induced cardiomyocyte apoptosis, whereas this protective effect was significantly attenuated in RLN3 knockdown cardiomyocytes, suggesting that Nur77-induced RLN3 expression is an important mediator for the suppression of cardiomyocyte apoptosis. These findings show that Nur77 regulates RLN3 expression, therefore suppressing apoptosis in the heart, and suggest that activation of Nur77 may represent a useful therapeutic strategy for inhibition of cardiac fibrosis and heart failure. © 2018 You et al