Pd-Catalyzed Highly Regio- and Stereoselective Formation of C–C Double Bonds: An Efficient Method for the Synthesis of Benzofuran‑, Dihydrobenzofuran‑, and Indoline-Containing Alkenes

A highly regio- and stereoselective C–C double bond formation reaction via Pd-catalyzed Heck-type cascade process with <i>N</i>-tosylhydrazones has been developed. Various <i>N</i>-tosylhydrazones derived from both ketones and aldehydes are found to be efficient substrates to provide di- and trisubstituted olefins with high regio- and stereoselectivity. Furthermore, this reaction has a good functional group tolerance and different benzofuran-, dihydrobenzofuran-, and indoline-containing alkene products were obtained with high selectivity

Copper-Catalyzed Oxysulfenylation of Enolates with Sodium Sulfinates: A Strategy To Construct Sulfenylated Cyclic Ethers

A new copper-catalyzed oxysulfenylation reaction of enolates with sodium sulfinates has been disclosed. A series of sulfenylated heterocycles including four- and seven-membered cyclic ether were obtained in mild to good yields. This reaction is proposed to go through a radical process, and the sulfur radical (RS^•) may be a reactive species

Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction

A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, readily available starting materials, and good functional group tolerance. Furthermore, this process was successfully applied to the synthesis of different 3-phenyl-1,4-dihydropyrrolo­[3,2-<i>b</i>]­indole derivatives via an intramolecular Buchwald–Hartwig cross-coupling reaction in two steps

Palladium-Catalyzed Multicomponent Reaction (MCR) of Propargylic Carbonates with Isocyanides

A palladium-catalyzed multicomponent reaction (MCR) of propargylic carbonates with isocyanides is reported. Remarkably, the orderly insertion of isocyanides affords two types of valuable <i>N</i>-heterocyclic products (<i>Z</i>)-6-imino-4,6-dihydro-1<i>H</i>-furo­[3,4-<i>b</i>]­pyrrol-2-amines and (<i>E</i>)-5-imino­pyrrolones in high yields. Systematic analysis of the reaction conditions indicates that the selectivity of these N-heterocyclic products can be controlled by ligands and temperature