1 research outputs found
Synthesis of Oxidant Prone Nanosilver To Develop H<sub>2</sub>O<sub>2</sub> Responsive Drug Delivery System
Our
immune system uses toxicity of hydrogen peroxide to kill off
bacterial invaders. In this contribution, we intended to integrate
ROS producing capability of immune system with oxidant-sensitive nature
of antibacterial silver nanoparticles (Ag NPs) to develop an oxidant
drug delivery system. Prior to execute this strategy, we have developed
an efficient one-pot synthetic protocol to produce ultrasmall (5 nm),
water-stable, and oxidant-prone Ag NPs. Notably, the yield of as-synthesized
Ag NPs is 10-fold higher than standard citrate reduction route. The
resulting therapeutically active and well-dispersed Ag NPs are used
as nanolids to cap the drug loaded nanochannels of porous silica.
Upon exposing to H<sub>2</sub>O<sub>2</sub>, dissolution-accompanied
aggregation of Ag nanolids unleashes the encapsulated therapeutic
entities from channels of nanocarrier. Combination of antibacterial
and anti-inflammatory drugs in single nanocarriers can potentially
augment the effectiveness of various therapies