Synthesis of Oxidant Prone Nanosilver To Develop H<sub>2</sub>O<sub>2</sub> Responsive Drug Delivery System
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Abstract
Our
immune system uses toxicity of hydrogen peroxide to kill off
bacterial invaders. In this contribution, we intended to integrate
ROS producing capability of immune system with oxidant-sensitive nature
of antibacterial silver nanoparticles (Ag NPs) to develop an oxidant
drug delivery system. Prior to execute this strategy, we have developed
an efficient one-pot synthetic protocol to produce ultrasmall (5 nm),
water-stable, and oxidant-prone Ag NPs. Notably, the yield of as-synthesized
Ag NPs is 10-fold higher than standard citrate reduction route. The
resulting therapeutically active and well-dispersed Ag NPs are used
as nanolids to cap the drug loaded nanochannels of porous silica.
Upon exposing to H<sub>2</sub>O<sub>2</sub>, dissolution-accompanied
aggregation of Ag nanolids unleashes the encapsulated therapeutic
entities from channels of nanocarrier. Combination of antibacterial
and anti-inflammatory drugs in single nanocarriers can potentially
augment the effectiveness of various therapies