Enhancing Heat Transfer in Internal Combustion Engine by Applying Nanofluids

Nanofluids exhibit novel properties including significant heat transfer properties that make them potentially useful in internal combustion engine cooling. However, although there is a substantial number of mechanisms proposed, modeling works related to their enhanced thermal conductivity, systematic mechanisms, or models that are suitable for nanofluids are still lacked. With molecular dynamics simulations, thermal conductivities of nanofluids with various nanoparticles have been calculated. Influence rule of various factors for thermal conductivity of nanofluids has been studied. Through defining the ratio of thermal conductivity enhancement by nanoparticle volume fraction, Κ, the impacts of nanoparticle properties for thermal conductivity are further evaluated. Furthermore, the ratio of energetic atoms in nanoparticles, E, is proposed to be an effective criterion for judging the impact of nanoparticles for the thermal conductivity of nanofluids. Mechanisms of heat conduction enhancement are investigated by MD simulations. Altered microstructure and movements of nanoparticles in the base fluid are proposed to be the main reasons for thermal conductivity enhancement in nanofluids. Both the static and dynamic mechanisms for heat conduction enhancement in nanofluids have been considered to establish a prediction model for thermal conductivity. The prediction results of the present model are in good agreement with experimental results

Growth, chemical components and ensiling characteristics of king grass at different cuttings

In order to effectively use and ensile king grass (Pennisetum purpureum × Pennisetum americanum), the present research investigated growth rate, yield, chemical components and silage fermentation quality of different cuttings. King grass was harvested four times, and the 1st and 3rd cuttings were ensiled directly or after wilting for 12 and 24 h. The results showed that the dry matter daily growth of 2nd cutting was significantly higher than that of other cuttings, and the 4th cutting was the lowest (P < 0.05). The contents of crude protein (CP), crude fat and water-soluble carbohydrates (WSC) tended to reduce, and crude ash tended to increase with the increase of cutting times. All four cuttings of king grass had higher WSC content, lower buffer capacity and much lactic acid bacteria, the silages made from unwilted 1st cutting and 3rd cutting were of good fermentation quality, indicated by low pH values and high V-scores. Wilting had different effects on the 1st cutting and 3rd cutting silages in pH value and NH3-N content, the 1st cutting silage tended to increase the pH values and NH3-N content, with moisture content reduction, while the 3rd cutting silage tended to reduce NH3-N content and its pH value was not affected by wilting (P > 0.05). Although the 3rd cutting silage had better aerobic stability than the 1st cutting silage, they all were not stable within 6 days of aerobic exposure. Considering the contents of CP, crude fat, crude fiber, crude ash and WSC, the 1st cutting of king grass might have best nutrient value, while the 4th cutting was contrary. Different cuttings of king grass could be well preserved by natural fermentation, but their aerobic stability was poor.Keywords: Cuttings, ensiling, king grass, nutrient component, wiltin

N-(4-hydroxyphenyl) retinamide inhibits migration of renal carcinoma cells and promotes autophagy via MAPK p38 pathway

Purpose: To investigate the effect of N-(4-hydroxyphenyl) retinamide (4HPR) on autophagy and migration of renal carcinoma cells.Methods: Renal cancer cell lines were treated with various concentrations of 4HPR. Proliferation of the cells was studied using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltrazolium bromide (MTT), while apoptosis and cell cycle arrest were determined by flow cytometry.Results: Treatment of RCCs with 30 μM 4HPR caused significant inhibition of viability. In 786-O and OS-RC-2 cell lines, 4HPR reduced colony formation by 39 and 43 %, respectively. In addition, 4HPR increased the percentage of 786-O cells in G1 phase from 58.79 ± 3.43 to 71.68 ± 4.47 % (p < 0.05). It also decreased the percentage of cells in the S-phase from 21.98 ± 2.78 to 09.17 ± 1.43 %, and enhanced the activation of p38 and JNK in 786-O cells at 48 h. Western blot assay showed that the activation of p38 and JNK by 4HPR was inhibited on pre-treatment with SB203580 (inhibitor of p38) and SP600125 (inhibitor of JNK), respectively. Reduction of 786-O cell viability by 4HPR treatment was also significantly inhibited by pre-treatment with sp203580 and sp600125 (p < 0.05). Furthermore, the inhibitors also reversed the effect of 4HPR on the expressions of Bax and Bcl-2 in 786-O cells.Conclusion: These results indicate that 4HPR inhibits the growth of renal cancer cells via activation of MAPK signalling pathway. Thus, 4HPR is a potential drug target for management of renal cancer.Keywords: Retinamide, Renal cancer, Autophagy, MAPK signalling, Cell proliferation, N-terminal kinas