Spin current through an ESR quantum dot: A real-time study

The spin transport in a strongly interacting spin-pump nano-device is studied using the time-dependent variational-matrix-product-state (VMPS) approach. The precession magnetic field generates a dissipationless spin current through the quantum dot. We compute the real time spin current away from the equilibrium condition. Both transient and stationary states are reached in the simulation. The essentially exact results are compared with those from the Hartree-Fock approximation (HFA). It is found that correlation effect on the physical quantities at quasi-steady state are captured well by the HFA for small interaction strength. However the HFA misses many features in the real time dynamics. Results reported here may shed light on the understanding of the ultra-fast processes as well as the interplay of the non-equilibrium and strongly correlated effect in the transport properties.Comment: 5 pages, 5 figure

Comprehensive Characterization of the Transmitted/Founder env Genes From a Single MSM Cohort in China

Background: The men having sex with men (MSM) population has become one of the major risk groups for HIV-1 infection in China. However, the epidemiological patterns, function of the env genes, and autologous and heterologous neutralization activity in the same MSM population have not been systematically characterized. Methods: The env gene sequences were obtained by the single genome amplification. The time to the most recent common ancestor was estimated for each genotype using the Bayesian Markov Chain Monte Carlo approach. Coreceptor usage was determined in NP-2 cells. Neutralization was analyzed using Env pseudoviruses in TZM-bl cells. Results: We have obtained 547 full-length env gene sequences by single genome amplification from 30 acute/early HIV-1–infected individuals in the Beijing MSM cohort. Three genotypes (subtype B, CRF01_AE, and CRF07_BC) were identified and 20% of the individuals were infected with multiple transmitted/founder (T/F) viruses. The tight clusters of the MSM sequences regardless of geographic origins indicated nearly exclusive transmission within the MSM population and limited number of introductions. The time to the most recent common ancestor for each genotype was 10–15 years after each was first introduced in China. Disparate preferences for coreceptor usages among 3 genotypes might lead to the changes in percentage of different genotypes in the MSM population over time. The genotype-matched and genotype-mismatched neutralization activity varied among the 3 genotypes. Conclusions: The identification of unique characteristics for transmission, coreceptor usage, neutralization profile, and epidemic patterns of HIV-1 is critical for the better understanding of transmission mechanisms, development of preventive strategies, and evaluation of vaccine efficacy in the MSM population in China

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in DNA-PKcs (DNA-PK catalytic subunit) degradation or whether it regulates the radiosensitivity of glioblastoma. Our data demonstrated that DNA-PKcs was ubiquitinated and bound to VCP. VCP knockdown resulted in the accumulation of the DNA-PKcs protein in glioblastoma cells, and the proteasome inhibitor MG132 synergised this increase. As expected, this increase promoted the efficiency of DNA repair in several glioblastoma cell lines; in turn, this enhanced activity decreased the radiation sensitivity and prolonged the survival fraction of glioblastoma cells in vitro. Moreover, the VCP knockdown in glioblastoma cells reduced the survival time of the xenografted mice with radiation treatment relative to the control xenografted glioblastoma mice. In addition, the VCP protein was also downregulated in ~25% of GBM tissues from patients (WHO, grade IV astrocytoma), and the VCP protein level was correlated with patient survival (R(2)=0.5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation

Applying a new interatomic potential for the modelling of hexagonal and orthorhombic YMnO3

We develop and apply an interatomic potential for YMnO3, based on the shell model together with the angular overlap model, which can model ligand field effects. The potential parameters accurately reproduce the complex structure of both hexagonal and orthorhombic phases of YMnO3. The rotation of the MnO6 octahedra in o-YMnO3 suggests the E-type AFM order. The potential is further employed to investigate the energies of intrinsic defects in the material. Lower defect energies were found in o-YMnO3. Oxygen Frenkel and Y2O3 partial Schottky are the most favourable defects in h-YMnO3 and o-YMnO3, respectively. The defect models proposed have implications for the properties of the related non-stoichiometric phases

Microarray-based ultra-high resolution discovery of genomic deletion mutations

BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations. CGH typically involves comparison of the hybridization intensities of genomic DNA samples with microarray chip representations of entire genomes, and has widespread potential application in experimental research and medical diagnostics. However, the power to detect small deletions is low. RESULTS: Here we use a graduated series of Arabidopsis thaliana genomic deletion mutations (of sizes ranging from 4 bp to ~5 kb) to optimize CGH-based genomic deletion detection. We show that the power to detect smaller deletions (4, 28 and 104 bp) depends upon oligonucleotide density (essentially the number of genome-representative oligonucleotides on the microarray chip), and determine the oligonucleotide spacings necessary to guarantee detection of deletions of specified size. CONCLUSIONS: Our findings will enhance a wide range of research and clinical applications, and in particular will aid in the discovery of genomic deletions in the absence of a priori knowledge of their existence

Random Access Analysis for Massive IoT Networks Under a New Spatio-Temporal Model: A Stochastic Geometry Approach

Massive Internet of Things (mIoT) has provided an auspicious opportunity to build powerful and ubiquitous connections that faces a plethora of new challenges, where cellular networks are potential solutions due to their high scalability, reliability, and efficiency. The Random Access CHannel (RACH) procedure is the first step of connection establishment between IoT devices and Base Stations (BSs) in the cellular-based mIoT network, where modelling the interactions between static properties of physical layer network and dynamic properties of queue evolving in each IoT device are challenging. To tackle this, we provide a novel traffic-aware spatio-temporal model to analyze RACH in cellular-based mIoT networks, where the physical layer network is modelled and analyzed based on stochastic geometry in the spatial domain, and the queue evolution is analyzed based on probability theory in the time domain. For performance evaluation, we derive the exact expressions for the preamble transmission success probabilities of a randomly chosen IoT device with different RACH schemes in each time slot, which offer insights into effectiveness of each RACH scheme. Our derived analytical results are verified by the realistic simulations capturing the evolution of packets in each IoT device. This mathematical model and analytical framework can be applied to evaluate the performance of other types of RACH schemes in the cellular-based networks by simply integrating its preamble transmission principle