Fault diagnosis of rolling bearing based on relevance vector machine and kernel principal component analysis

In order to improve the speed and accuracy of rolling bearing fault diagnosis on small samples, a method based on relevance vector machine (RVM) and Kernel Principle Component Analysis (KPCA) is proposed. Firstly, the wavelet packet energy of the vibration signal is extracted with the wavelet packet transform, which is used as fault feature vectors. Secondly, the dimension of feature vectors is reduced in order to weaken the correlation between the features. The important principal components are selected using KPCA as the new feature vectors under the criterion that the cumulative variance is greater than 95 %. Finally, the faults of rolling bearing are diagnosed through combining KPCA with RVM. Simulation experimental indicates the advantages of the presented method. Moreover, the proposed approach is applied to diagnoses rolling bearing fault. The results show that wavelet packet energy can express rolling bearing fault features accurately, KPCA can reduce the dimension of feature vectors effectively and the proposed method has better performance in the speed of fault diagnosis than the method based on support vector machine (SVM), which supplies a strategy of fault diagnosis for rolling bearing. In this paper, the performance of the proposed method is also compared with other diagnostic methods

The prevalence of depressive symptoms among older patients with hypertension in rural China

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139900/1/gps4628.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139900/2/gps4628_am.pd

Comparative analysis of adipokinetic hormones and their receptors in Blattodea reveals novel patterns of gene evolution

Adipokinetic hormone (AKH) is a neuropeptide produced in the insect corpora cardiaca that plays an essential role in mobilising carbohydrates and lipids from the fat body to the haemolymph. AKH acts by binding to a rhodopsin-like G protein-coupled receptor (GPCR), the adipokinetic hormone receptor (AKHR). In this study, we tackle AKH ligand and receptor gene evolution as well as the evolutionary origins of AKH gene paralogues from the order Blattodea (termites and cockroaches). Phylogenetic analyses of AKH precursor sequences point to an ancient AKH gene duplication event in the common ancestor of Blaberoidea, yielding a new group of putative decapeptides. In total, 16 different AKH peptides from 90 species were obtained. Two octapeptides and seven putatively novel decapeptides are predicted for the first time. AKH receptor sequences from 18 species, spanning solitary cockroaches and subsocial wood roaches as well as lower and higher termites, were subsequently acquired using classical molecular methods and in silico approaches employing transcriptomic data. Aligned AKHR open reading frames revealed 7 highly conserved transmembrane regions, a typical arrangement for GPCRs. Phylogenetic analyses based on AKHR sequences support accepted relationships among termite, subsocial (Cryptocercus spp.) and solitary cockroach lineages to a large extent, while putative post-translational modification sites do not greatly differ between solitary and subsocial roaches and social termites. Our study provides important information not only for AKH and AKHR functional research but also for further analyses interested in their development as potential candidates for biorational pest control agents against invasive termites and cockroaches

Protocol of an ongoing randomized controlled trial of care management for comorbid depression and hypertension: the Chinese Older Adult Collaborations in Health (COACH) study

Abstract Background Depression and hypertension are common, costly, and destructive conditions among the rapidly aging population of China. The two disorders commonly coexist and are poorly recognized and inadequately treated, especially in rural areas. Methods The Chinese Older Adult Collaborations in Health (COACH) Study is a cluster randomized controlled trial (RCT) designed to test the hypotheses that the COACH intervention, designed to manage comorbid depression and hypertension in older adult, rural Chinese primary care patients, will result in better treatment adherence and greater improvement in depressive symptoms and blood pressure control, and better quality of life, than enhanced Care-as-Usual (eCAU). Based on chronic disease management and collaborative care principles, the COACH model integrates the care provided by the older person’s primary care provider (PCP) with that delivered by an Aging Worker (AW) from the village’s Aging Association, supervised by a psychiatrist consultant. One hundred sixty villages, each of which is served by one PCP, will be randomly selected from two counties in Zhejiang Province and assigned to deliver eCAU or the COACH intervention. Approximately 2400 older adult residents from the selected villages who have both clinically significant depressive symptoms and a diagnosis of hypertension will be recruited into the study, randomized by the villages in which they live and receive primary care. After giving informed consent, they will undergo a baseline research evaluation; receive treatment for 12 months with the approach to which their village was assigned; and be re-evaluated at 3, 6, 9, and 12 months after entry. Depression and HTN control are the primary outcomes. Treatment received, health care utilization, and cost data will be obtained from the subjects’ electronic medical records (EMR) and used to assess adherence to care recommendations and, in a preliminary manner, to establish cost and cost effectiveness of the intervention. Discussion The COACH intervention is designed to serve as a model for primary care-based management of common mental disorders that occur in tandem with common chronic conditions of later life. It leverages existing resources in rural settings, integrates social interventions with the medical model, and is consistent with the cultural context of rural life. Trial registration ClinicalTrials.gov ID: NCT01938963 ; First posted: September 10, 2013.https://deepblue.lib.umich.edu/bitstream/2027.42/143862/1/12877_2018_Article_808.pd

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.

α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding activities, contributing differently to synucleinopathies. Despite numerous prior attempts, how polymorphic aSyn fibrils differ in atomic structure remains elusive. Here, we present fibril polymorphs from the full-length recombinant human aSyn and their seeding capacity and cytotoxicity in vitro. By cryo-electron microscopy helical reconstruction, we determine the structures of the two predominant species, a rod and a twister, both at 3.7 Å resolution. Our atomic models reveal that both polymorphs share a kernel structure of a bent β-arch, but differ in their inter-protofilament interfaces. Thus, different packing of the same kernel structure gives rise to distinct fibril polymorphs. Analyses of disease-related familial mutations suggest their potential contribution to the pathogenesis of synucleinopathies by altering population distribution of the fibril polymorphs. Drug design targeting amyloid fibrils in neurodegenerative diseases should consider the formation and distribution of concurrent fibril polymorphs

Genome-wide identification reveals conserved carbohydrate-active enzyme repertoire in termites

Termites play an important role as decomposers of organic matter in forests by utilizing their gut symbionts and associated carbohydrate-active enzymes (CAZymes) to digest wood materials. However, there is a limited understanding of the entire repertoire of CAZymes and their evolution in termite genomes. Here we identified the gene families of CAZymes in publicly available termite genomes and analyzed the evolution of abundant gene families. We found that 79 CAZyme gene families from the carbohydrate-binding module and four CAZyme classes, including glycosyl transferase (GT), glycoside hydrolase (GH), auxiliary activity (AA) and carbohydrate esterase (CE), were present in termites with minor variations across termite species except for a few gene families. The gene trees of the large and conserved gene families have several groups of genes from all species, and each group encodes enzymes with complete corresponding domains. Three gene families, namely GT1, GH1 and AA3, exhibited significant variations in gene numbers and experienced several losses and a few duplications, which might be related to their rich gut symbionts and newly gained functions. Furthermore, the overall expression of CAZymes appears to have a caste- and tissue-specific pattern, reflecting a division of labor in termite colonies. Overall, these results reveal a likely stable CAZyme repertoire in termites and pave the way for further research on the functional contribution of termites to wood digestion