The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.

The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38-/-, TAp63+/-, and Rbm38-/-;TAp63+/- mice were generated and monitored throughout their lifespan. While mice deficient in Rbm38 or TAp63 alone died mostly from spontaneous tumors, compound Rbm38-/-;TAp63+/- mice had an extended lifespan along with reduced tumor incidence. We also found that loss-of-Rbm38 markedly decreased the percentage of liver steatosis in TAp63+/- mice. Moreover, we found that Rbm38 deficiency extends the lifespan of tumor-free TAp63+/- mice along with reduced expression of senescence-associated biomarkers. Consistent with this, Rbm38-/-;TAp63+/- MEFs were resistant, whereas Rbm38-/- or TAp63+/- MEFs were prone, to cellular senescence. Importantly, we showed that the levels of inflammatory cytokines (IL17D and Tnfsf15) were significantly reduced by Rbm38 deficiency in senescence-resistant Rbm38-/-;TAp63+/- mouse livers and MEFs. Together, our data suggest that Rbm38 and p63 function as intergenic suppressors in aging and tumorigenesis and that the Rbm38-p63 loop may be explored for enhancing longevity and cancer management

Edge states induce boundary temperature jump in molecular dynamics simulation of heat conduction

We point out that the origin of the commonly occurred boundary temperature jump in the application of No\'se-Hoover heat bath in molecular dynamics is related to the edge modes, which are exponentially localized at the edge of the system. If heat baths are applied to these edge regions, the injected thermal energy will be localized thus leading to a boundary temperature jump. The jump can be eliminated by shifting the location of heat baths away from edge regions. Following this suggestion, a very good temperature profile is obtained without increasing any simulation time, and the accuracy of thermal conductivity calculated can be largely improved.Comment: accepted by PRB, brief report, references added, typo correcte

A Scale-Free Topology Construction Model for Wireless Sensor Networks

A local-area and energy-efficient (LAEE) evolution model for wireless sensor networks is proposed. The process of topology evolution is divided into two phases. In the first phase, nodes are distributed randomly in a fixed region. In the second phase, according to the spatial structure of wireless sensor networks, topology evolution starts from the sink, grows with an energy-efficient preferential attachment rule in the new node's local-area, and stops until all nodes are connected into network. Both analysis and simulation results show that the degree distribution of LAEE follows the power law. This topology construction model has better tolerance against energy depletion or random failure than other non-scale-free WSN topologies.Comment: 13pages, 3 figure

Data Detection and Code Channel Allocation for Frequency-Domain Spread ACO-OFDM Systems Over Indoor Diffuse Wireless Channels

Future optical wireless communication systems promise to provide high-speed data transmission in indoor diffuse environments. This paper considers frequency-domain spread asymmetrically clipped optical orthogonal frequency-division multiplexing (ACOOFDM) systems in indoor diffuse channels and aims to develop efficient data detection and code channel allocation schemes. By exploiting the frequency-domain spread concept, a linear multi-code detection scheme is proposed to maximize the signal to interference plus noise ratio (SINR) at the receiver. The achieved SINR and bit error ratio (BER) performance are analyzed. A computationally efficient code channel allocation algorithm is proposed to improve the BER performance of the frequency-domain spread ACO-OFDM system. Numerical results show that the frequency-domain spread ACO-OFDM system outperforms conventional ACO-OFDM systems in indoor diffuse channels. Moreover, the proposed linear multi-code detection and code channel allocation algorithm can improve the performance of optical peak-to-average power ratio (PAPR