865 research outputs found

    Rotective effect of Fengliao-Changweikang extracts, a traditional Chinese herbal medicine formula,on mucosa in rat with chronic gastritis

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    Background: Fengliao-Changwei-Kang(FCK), the Chinese patent drug, is a famous traditional Chinese herbal medicine formula. It has a significant effect on the clinic treatment of gastrointestinal diseases  including gastritis, enteritis and diarrhea for many years. However, there is few research on the  protective effects of FCK on the gastric mucosa of chronic gastritis (CG) model rat. Objective: The present study aimed to explore the effects of FCK extract on mucosa in rats with Chronic Gastritis.Materials and Methods: 50 SD mice were randomly divided into 5 groups with 10 in each group(five per sex). The groups are respectively control group, model group, low, middle and high FCK extracts (FCK I, II and III) group. The CG rat model was induced by synthetic methods. FCK I, II and III group were  administrated with FCK extracts at 2.16g• kg, 4.32g• kg, 8.94g• kg once per day for 21 consecutive  days, and the control group and model group were administrated the same volume of distilled water at 10mL/kg once per day. 16 hours after the last administration, the rats were anesthetized and their blood and stomach were drawn from vena cava and abdominal cavity. The serum levels of EGF was measured by enzyme linked immunosorbent assay(ELISA) method, the expression of growth factor receptor (EGFR) in gastric mucosa was detected by immunohistochemical method, and the mRNA expressions of NF-κB p65 was detected in-situ hybridization.Results: The inflammation grades and the expressions of NF-κB p65 mRNA in gastric mucosa of the model group were markedly higher than those of the control group (P<0.05). The inflammation grades of gastric mucosa and the expressions of NF-κB p65 mRNA in gastric mucosa the FCK extract group are significantly lower than those of the model group, and the FCK extract group at 8.64g/kg could greatly increase the serum levels of EGF and the expressions of EGFR in gastric mucosa. High EGF level was found in FCK extract group at 4.32g/kg, but low in FCK extract groups at 2.16g/kg. There were no marked differences among the rats from control group, model group and FCK extract group on ratio of Ll/L2 (P>0.05).Conclusions: FCK extract could alleviate mucosal inflammation by down regulating the expressions of NF-κB p65 mRNA and promote tissue repair by up regulating EGFR expression in gastric mucosa cell.Keywords: chronic gastritis; fengliao-changwei-kang extract; epidermal growth factor receptor; nuclear factor kappa B

    Oxidation of Methyl Orange Solution with Potassium Peroxydisulfate

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    ABSTRACT: Oxidation of Methyl Orange (MO) solution in potassium peroxydisulfate (KPS) homogeneous reaction system without UV irradiation was investigated. The result shows that decolorization of MO increases as the dosage of K 2 S 2 O 8 increases. The kinetic results demonstrate that the decolorization reaction is a pseudo first-order reaction when the concentration of MO is below 10 mg/L and Langmuir-Hinshewood kinetic model (L-H) can well described it, the value of Ea is 19.5 kJ/mol. The decolorization efficiency is low when the pH value is low ( 2). Result of CODCr shows MO can be effectively mineralized with KPS direct oxidation. The knowledge on the kinetics of the system and influence of some parameters on the system possesses both practical and theoretical values

    Quantum Liouville Theory On The Riemann Sphere With n>3n>3 Punctures

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    We have studied the quantum Liouville theory on the Riemann sphere with n>3 punctures. While considering the theory on the Riemann surfaces with n=4 punctures, the quantum theory near an arbitrary but fixed puncture can be obtained via canonical quantization and an extra symmetry is explored. While considering more than four distinguished punctures, we have found the exchange relations of the monodromy parameters from which we can get a reasonable quantum theory.Comment: 13 page
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