The Systemic Evaluation and Clinical Significance of Immunological Function for Advanced Lung Cancer Patients

Background and objective The actual evaluation of immunological function is significant for studing the tumor development and devising a treatment in time. The aim of this study is to evaluate the immunological function of advanced lung cancer patients systematically, and to discuss the clinical significance. Methods The nucleated cell amounts of advanced lung cancer patients and the healthy individuals were counted. The immune cell subsets and the levels of IL-4, INF-γ, perforin and granzyme in CD8+T cells by the flow cytometry were measured. The proliferation activity and the inhibition ratio of immune cells to several tumor cell lines were evaluated by MTT assay. Results The absolute amounts and subsets of T, B, NK cells of advanced lung cancer patients were lower than the healthy individuals (P < 0.05); However, the proportion of regulatory T cells of advanced lung cancer patients (4.00±1.84)% was lower than the healthy individuals (1.27±0.78)% (P < 0.05). The positive rates of IFN-γ perforin, granzyme in CD8+T cells decreased while them in IL-4 did not in the advanced lung cancer patients compared to the healthy control group (P < 0.05). The proliferation activity of immune cells, the positive rate of PPD masculine and the inhibition ratio to tumor cells in the advanced lung cancer patients was lower than the healthy subsets obviously (P < 0.05). Conclusion There was a significant immune depression in the advanced lung cancer patients compared to the healthy individuals

Effect of prestrain on the fracture toughness of steel 16MnR

The prestrain on 16MnR steel was found experimentally to influenceupon its fracture toughness remarkably. During fracturing, the microstructural chan-ge was taken place in the crack tip zone, The cracks will propagate on the second-ary pearlite structure. It is believed that the fracture toughness of 16MnR steel isdependent on the diffusion of carbon atoms and the formability of secondary pearl-ite structure

Study on freeze-thaw resistance with NaCl of desert sand engineering cement composites

To test the salt-freezing resistance performance of desert sand engineering cement composite (DSECC) prepared by different types of desert sand, the specimens with 3% NaCl solution on the top surface after 56 days of curing were tested by one-sided freeze-thaw cycles (FTC) and compression test after freezing and thawing. Two desert sands were collected from the Tengger Desert and Mu Us Desert in China, denoted T and M. The appearance, water absorption rate, mass loss rate, relative dynamic elastic modulus and longitudinal ultrasonic speed of the DSECC were tested after 0, 4, 8, 12, 16, 20, 24 and 28 cycles of freeze-thaw. Compressive strength was tasted after 8, 16, 24, and 32 cycles of freeze-thaw. Results show that FTC can accelerate the damage of the appearance. Meanwhile, the water absorption rate increases, the relative dynamic elastic modulus, the longitudinal ultrasonic wave speed, and the compressive strength decreases. Under the same FTC, the salt-freezing resistance performance of DSECC using T has slightly better than that using M

Enhanced half-metallicity in the zigzag graphene nanoribbons by adsorption of the zigzag hydrogen fluoride molecular chains

A comprehensive theoretical study of the half-metallicity in the zigzag graphene nanoribbons (ZGNRs) by adsorption of the zigzag hydrogen fluoride chains was presented. The ZGNR by adsorption of the hydrogen fluoride chains could be half-metallic when a critical length of the hydrogen fluoride chain is achieved on the ZGNR at low temperature. It was found that the strong dipole moments of the hydrogen fluoride chains act as the constant electric field. Our results suggest a huge possibility in spintronics device applications for achieving half-metallicity in the ZGNRs without the excessively high external electric fields

A new species of the genus Zographetus Watson, 1893 from China (Lepidoptera: Hesperiidae)

Xue, Guoxi, Li, Meng, Li, Xiaojuan, Xie, Guoguang, Chen, Keda, Li, Jialing (2019): A new species of the genus Zographetus Watson, 1893 from China (Lepidoptera: Hesperiidae). Zootaxa 4629 (2): 255-262, DOI: https://doi.org/10.11646/zootaxa.4629.2.

Descriptions of Pedesta wangi sp. nov. and the female of P. xiaoqingae (Huang & Zhan, 2004) from China (Lepidoptera: Hesperiidae)

Xue, Guoxi, Li, Meng, Zhu, Jianqing, Lu, Weicheng, Li, Jialing, Zheng, Bowen (2019): Descriptions of Pedesta wangi sp. nov. and the female of P. xiaoqingae (Huang & Zhan, 2004) from China (Lepidoptera: Hesperiidae). Zootaxa 4700 (3): 356-364, DOI: https://doi.org/10.11646/zootaxa.4700.3.

A Multifrequency Brain Network-Based Deep Learning Framework for Motor Imagery Decoding

Motor imagery (MI) is an important part of brain-computer interface (BCI) research, which could decode the subject’s intention and help remodel the neural system of stroke patients. Therefore, accurate decoding of electroencephalography- (EEG-) based motion imagination has received a lot of attention, especially in the research of rehabilitation training. We propose a novel multifrequency brain network-based deep learning framework for motor imagery decoding. Firstly, a multifrequency brain network is constructed from the multichannel MI-related EEG signals, and each layer corresponds to a specific brain frequency band. The structure of the multifrequency brain network matches the activity profile of the brain properly, which combines the information of channel and multifrequency. The filter bank common spatial pattern (FBCSP) algorithm filters the MI-based EEG signals in the spatial domain to extract features. Further, a multilayer convolutional network model is designed to distinguish different MI tasks accurately, which allows extracting and exploiting the topology in the multifrequency brain network. We use the public BCI competition IV dataset 2a and the public BCI competition III dataset IIIa to evaluate our framework and get state-of-the-art results in the first dataset, i.e., the average accuracy is 83.83% and the value of kappa is 0.784 for the BCI competition IV dataset 2a, and the accuracy is 89.45% and the value of kappa is 0.859 for the BCI competition III dataset IIIa. All these results demonstrate that our framework can classify different MI tasks from multichannel EEG signals effectively and show great potential in the study of remodelling the neural system of stroke patients

Examining the Structure of Difficulties in Emotion Regulation Scale with Chinese Population: A Bifactor Approach

The Difficulties in Emotion Regulation Scale (DERS), as one of the most frequently employed measures of emotion regulation (ER), has increasingly been used in numerous researches and applications. However, the structures derived from previous factor-analytic studies have a high degree of inconsistency. In the current study, both the traditional factor analysis method and novel (bifactor) modeling approaches were employed to examine the most optimal measurement structure of the DERS in a sample of 1036 Chinese participants. After a series of comparisons, the findings indicated that the bifactor model, with a general ER factor and four distinct subdimensions, was the most optimal structure for the DERS. Based on the study’s findings, the discussion was focused mainly on the future directions and the implications of this bifactor model. The impact and limitations of the study were also discussed, and several suggestions for future research were provided at the end of the paper

Path Analysis of Quantitative Characters for Mactra veneriformis with Different Ages in Geligang

Mactra veneriformis is a common economic benthic shellfish with high nutritional value and is widely distributed in the Shandong and Liaoning provinces. Geligang is located in the northern part of Liaodong Bay. It is formed by the water impact of Shuangtaizi and Liaohe River. It has an area of approximately 10 000 hm2 with a fertile substrate. It is an important habitat of beach shellfish, such as M. veneriformis. Studies on the influencing factors of wild population quality traits and their correlation with morphological traits are helpful for developing genetic breeding of marine shellfish. To analyze the effects of morphological traits on quality traits of M. veneriformis at different ages in Geligang, the shell length (SL), shell width (SW), shell height (SH), body weight (BW), and soft tissue wet weight (RW) of 1–3 years old M. veneriformis were analyzed using correlation analysis, path analysis, and multiple regression analysis. The M. veneriformis used in the experiment was obtained from the Geliang in Liaodong Bay in September 2022. A total of 80 1-year-old, 104 2-year-old, and 168 3-year-old M. veneriformis were obtained. The results showed that the morphological traits of M. veneriformis at different growth stages had different contributions to quality traits, and there were significant differences (P 0.05) and was eliminated. The optimal regression equation of quantitative traits to qualitative traits of 1–3 year-old M. veneriformis was established. The results showed that when BW was the target trait, SW was the main selection trait and SL was the auxiliary selection trait for 1–3 year-old M. veneriformis. When RW was the target trait, SW should be the main selection trait for 1-year-old M. veneriformis, supplemented by SL. The SL should be the main selection trait for both 2- and 3-year-old M. veneriformis, but the SW was the auxiliary selection trait for 2-year-old M. veneriformis, while the SH was for 3-year-old M. veneriformis. In this study, correlation analysis, path analysis, and multiple regression analysis were performed on the morphological traits and quality traits of 1–3 years old M. veneriformis to determine the key morphological traits affecting the quality traits of M. veneriformis at different ages. In this study, the R2 values of the morphological traits of 1- and 2-year-old M. veneriformis (0.898 and 0.859, respectively) were greater than 0.850, indicating that the main factors affecting the body weight of living M. veneriformis were found. However, the R2 value of the morphological traits of 3-year-old M. veneriformis (0.815) was below 0.850, indicating that there may be other influencing traits in addition to the traits analyzed in this study. The reason may be that with the growth of M. veneriformis, the thickness of the shell and the effect on the weight of the living body gradually increase. In this study, the R2 values of morphological traits of 1–3 years old M. veneriformis (0.738, 0.648, and 0.538, respectively) on the wet weight of soft tissue were all below 0.850, indicating that there were other key factors affecting the wet weight of soft tissue. The age of sexual maturity of the M. veneriformis is at 1 year. The development of the gonad in the soft part may be closely related to the size of the wet weight of the soft tissue. The sampling period is mainly in the proliferation to depletion period of the gonad development of M. veneriformis. The gonad development is simultaneously affected by the environment. These results can provide reference for breeding M. veneriformis and the selection of parent shellfish

The Role of Gluten in Food Products and Dietary Restriction: Exploring the Potential for Restoring Immune Tolerance

Wheat is extensively utilized in various processed foods due to unique proteins forming from the gluten network. The gluten network in food undergoes morphological and molecular structural changes during food processing, affecting the final quality and digestibility of the food. The present review introduces the formation of the gluten network and the role of gluten in the key steps of the production of several typical food products such as bread, pasta, and beer. Also, it summarizes the factors that affect the digestibility of gluten, considering that different processing conditions probably affect its structure and properties, contributing to an in-depth understanding of the digestion of gluten by the human body under various circumstances. Nevertheless, consumption of gluten protein may lead to the development of celiac disease (CD). The best way is theoretically proposed to prevent and treat CD by the inducement of oral tolerance, an immune non-response system formed by the interaction of oral food antigens with the intestinal immune system. This review proposes the restoration of oral tolerance in CD patients through adjunctive dietary therapy via gluten-encapsulated/modified dietary polyphenols. It will reduce the dietary restriction of gluten and help patients achieve a comprehensive dietary intake by better understanding the interactions between gluten and food-derived active products like polyphenols