Effect of optimized thrombus aspiration on myocardial perfusion and prognosis in acute ST-segment elevation myocardial infarction patients with primary percutaneous coronary intervention

ObjectiveTo investigate the impact of optimized thrombus aspiration on myocardial perfusion, prognosis, and safety in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention(primary PCI).MethodsA total of 129 patients with STEMI were randomly allocated into control group (Subgroup A and B) and experimental group(Subgroup C and D). Control group received percutaneous transluminal coronary angioplasty (PTCA),thrombus aspiration and primary PCI. Experimental group received optimized thrombus aspiration and primary PCI. The number of thrombus aspiration was less than 4 times in Subgroup A and C. The number of thrombus aspiration was performed more than 4 times in Subgroups B and D. The classification of thrombi extracted, the TIMI flow grade, the incidence of no-reflow and slow flow, cTFC, TPI and CK-MB at 12 h and 24 h after stenting, ST segment resolution of ECG after stenting, NT-proBNP, LVEFat 24 h, 30 days and 180 days after stenting were compared between groups. The incidence of intraoperative and postoperative bleeding complications, stroke events and major cardiovascular events (MACE) were recorded and compared between groups.ResultsThe classification of thrombi extracted in the experimental group was higher than that in the control group. The TIMI flow grade of the experimental group was better than the control group after thrombus aspiration. After stenting, the advantage still existed, but the difference was not statistically significant. On cTFC, the experimental group was lower than the control group, but the difference was not statistically significant; After stenting the experimental group was significantly lower than the control group. The CK-MB at 12 h and 24 h of the experimental group was lower than the control group. After thrombus aspiration the incidence of no-reflow in the experimental group was significantly lower than that in the control group; after stenting the incidence of no-reflow in the experimental group was still lower than the control group, but no statistically difference. After thrombus aspiration and stenting the incidence of slow flow in the experimental group were lower than that in the control group. After stenting, NT-proBNP at 24 h was lower in the experimental group than that in the control group, However, there was no statistical difference; after stenting, The NT-proBNP in the experimental group was lower than that in the control group at 30 days and 180 days. After stenting, LVEF of the experimental group was significantly higher than the control group at 24 h and 30 days; superiority remained after 180 days but no statistical difference. There was no statistical difference between two groups for intraoperative and postoperative bleeding complications, stroke events, and MACE events. In Subgroup analysis,there was no significant difference in the classification of thrombi extracted, TIMI flow grade, cTFC, CK-MB,NT-proBNP and LVEF between group C and D, but group A was better than group B. Analysis of variance showed that the optimal number of suction was 4–5 times.ConclusionsOptimized thrombus aspiration can significantly improve myocardial perfusion and short-term and medium-term prognosis of STEMI patients after PCI, and reduce the incidence of slow flow and no-reflow. The optimal suction times were 4–5 times. Traditional aspiration method with more aspiration times is harmful to cardiac prognosis. Thrombus aspiration does not increase the incidence of stroke events and is safe.Clinical Trial Registration: identifier, ChiCTR2300073410

Study on Seed Dormancy and Germination Characteristics of Portulaca pilosa

To improve understanding of Portulaca pilosa seed germination and lay technical foundation for seedling cultivation, this paper studies the characteristics of dormancy and germination of Portulaca pilosa seed. Research indicates that its primary seed dormancy period is about 25 d, dormancy can be completely released by storage at room temperature for 30 d; the seed is positively photoblastic seed that can’t sprout and can be induced into dormancy in low light conditions; the dormancy-released seed is more sensitive to light when compared with the freshly picked seed, and the germination peak arises 1 d earlier; Portulaca pilosa seed favorites humid conditions, and the higher the soil moisture, the higher the germination rate and germination energy of the seed. The dormancy-released seeds should be used for Portulaca pilosa seedling cultivation, and after the germination is accelerated for 2-3 d in the light conditions, the seeds are sown on the soil surface, and covered with transparent plastic film to keep moisture and light, which is conducive to the emergence of seeds

Development and Test Application of an Auxiliary Power-Integrated System

This paper focuses on the design and test technique of an auxiliary power unit (APU) for a range-extended electric vehicle (RE-EV). The APU system is designed to improve RE-EV power and economy; it integrates the power system, generator system, battery system, and APU controller. The parameters of the APU parts are computed and optimized considering the vehicle power demand and the matching characteristic of the engine and generator. The hardware and software systems are developed for the APU-integrated control system. The APU test bench, combined with the displaying part, the control part, and the bench with its accessory, is constructed. Communication connection in the APU system is established by controller area network (CAN) bus. The APU controller outputs a corresponding signal to the engine control unit (ECU) and motor controller. To verify the rationality of the control strategy and the validity of the control logic, the engine speed control and integrated control experiment of the APU system are completed on the test bench. The test results showed that the test control system is reliable and the relevant control logic is in agreement with simulation analysis. The APU-integrated system could be well suited for application in RE-EVs

Anomaly Internet Network Traffic Detection by Kernel Principle Component Classifier

As a crucial issue in computer network security, anomaly detection is receiving more and more attention from both application and theoretical point of view. In this paper, a novel anomaly detection scheme is proposed. It can detect anomaly network traffic which has extreme large value on some original feature by the major component, or does not follow the correlation structure of normal traffic by the minor component. By introducing kernel trick, the nonlinearity of network traffic can be well addressed. To save the processing time, a simplified version is also proposed, where only major component is adopted. Experimental results validate the effectiveness of the proposed scheme

A novel molybdenum-based nanocrystal decorated ceramic membrane for organics degradation via catalytic wet air oxidation (CWAO) at ambient conditions

Catalytic wet air oxidation (CWAO), one of the best-known methods for water treatment, has been intensely investigated for dyes degradation. However, the extreme operation conditions as well as the recovery of suspended catalyst are economically unattractive. In the current work, a novel Mo-based nanocrystal decorated ceramic membrane (Mo/Al2O3) has been prepared and applied for organics degradation via CWAO at ambient conditions for the first time. The catalytic Mo/Al2O3 membranes were prepared by an in-situ hydrothermal followed by calcination method. Their physical and chemical properties were characterized by field emission scanning electron microscope (FESEM), X-rays diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS). The catalytic performance of Mo/Al2O3 membranes were evaluated via organics (safranine O and humic acid) degradation under a home-made membrane filtration system. The effects of calcination temperature, catalyst loading amount, and trans-membrane pressure (TMP) were systematically investigated. The stability and durability of the catalytic Mo/Al2O3 membrane were examined in a long-term filtration system. Results showed that the performance of Mo/Al2O3 membrane would decrease with increasing of calcination temperature as well as TMP. However, the catalyst loading amount was not a major effect on the removal of organics in the system. For one-time loading membrane calcined at 300 °C (1x-Mo/Al2O3 membrane@300), the removal efficiency could achieve higher than 90 % in 40 min in a recycled filtration system with an initial safranine O concentration of 10 mg L−1. The chemical quenching experiment as well as radical quantification verified the main reactive oxygen species were 1O2 and [rad]O2− in the system. The ROS generation mechanism was proposed via the characterization of the catalyst after reaction. The deliberate combination of CWAO and membrane separation represents a new strategy that offers exciting possibilities for water treatment under ambient conditions.Nanyang Technological UniversityFinancial support for this project is provided by the Ph.D. research scholarship from NTU

Insight into Fe(II)/UV/chlorine pretreatment for reducing ultrafiltration (UF) membrane fouling : effects of different natural organic fractions and comparison with coagulation

Fe(II)/UV/chlorine was promoted as a pretreatment strategy for UF membrane to mitigate membrane fouling induced from different organic fractions. This treatment could be an emerging alternative prior to UF process attributed to the coupled role of oxidation and coagulation. To obtain a comprehensive understanding of fouling reduction, the influence of Fe(II)/UV/chlorine process on the characteristics of various feed solutions was inspected, including humic acid (HA), bovine serum albumin (BSA), sodium alginate (SA) and their mixture (HSB). The results suggested that Fe(II)/UV/chlorine process exhibited notable performance on membrane fouling control compared to Fe(II) coagulation alone. With the UV exposure of 720 mJ/cm2, the certain dose of Fe(II) and chlorine (15 μM and 2 mg/L) effectively prevented the rapid development of fouling caused by the single organic fractions and their mixture. And the increased dosage promoted the performance of membrane fouling mitigation. The reduction of organic loadings and characteristics change of feed water took the main responsibility for the fouling alleviation. The properties of membrane fouling and their correlation with feed water qualities were analyzed. The results and insight analysis were supposed to evaluate and predict the effectiveness of fouling control when the feed solutions were pretreated by Fe(II)/UV/chlorine process according to various compositions and characteristics of the organic fractions.This research was jointly supported by the National Key Research and Development Program of China (2018YFC0408001), the National Natural Science Foundation of China (51778170), the Nanqi Ren Studio, Academy of Environment & Ecology, Harbin Institute of Technology (HSCJ201701) and Fundamental Research Funds for the Central Universities