Immunogenicity and tolerance induction in vascularized composite allotransplantation

Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optimized, issues regarding graft rejection remains. VCA rejection involves a diverse population of cells but is primarily driven by both donor and recipient lymphocytes, antigen-presenting cells, macrophages, and other immune as well as donor-derived cells. In addition, it is commonly understood that different tissues within VCA, such as the skin, elicits a stronger rejection response. Currently, VCA recipients are required to follow potent and lifelong immunosuppressing regimens to maximize graft survival. This puts patients at risk for malignancies, opportunistic infections, and cancers, thereby posing a need for less perilous methods of inducing graft tolerance. This review will provide an overview of cell populations and mechanisms, specific tissue involved in VCA rejection, as well as an updated scope of current methods of tolerance induction

Improved measurement of CPCP violation parameters in Bs0→J/ψK+K−B_s^0\to J/\psi K^+K^- decays in the vicinity of the ϕ(1020)\phi(1020) resonance

The decay-time-dependent $CP$ asymmetry in $B_s^0\to J/\psi(\to \mu^+\mu^-) K^+ K^-$ decays is measured using proton-proton collision data, corresponding to an integrated luminosity of $6 {\rm fb}^{-1}$, collected with the LHCb detector at a center-of-mass energy of 13 TeV. Using a sample of approximately 349 000 $B_s^0$ signal decays with an invariant $K^+ K^-$ mass in the vicinity of the $\phi(1020)$ resonance, the $CP$-violating phase $\phi_s$ is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the $B_s^0$-$\overline{B}_s^0$ system, $\Delta\Gamma_s$, and the difference of the average $B_s^0$ and $B^0$ meson decay widths, $\Gamma_s-\Gamma_d$. The values obtained are $\phi_s = -0.039 \pm 0.022 \pm 0.006$ rad, $\Delta\Gamma_s = 0.0845 \pm 0.0044 \pm 0.0024 ~{\rm ps}^{-1}$ and $\Gamma_s-\Gamma_d = -0.056^{\:+\:0.0013}_{\:-\:0.0015} \pm 0.0014 ~{\rm ps}^{-1}$, where the first uncertainty is statistical and the second systematic. These are the most precise single measurements to date and are consistent with expectations based on the Standard Model and with the previous LHCb analyses of this decay. These results are combined with previous independent LHCb measurements. The phase $\phi_s$ is also measured independently for each polarization state of the $K^+K^-$ system and shows no evidence for polarization dependence.The decay-time-dependent $CP$ asymmetry in $B^0_s\to J/\psi(\to \mu^{+}\mu^{-}) K^{+}K^{-}$ decays is measured using proton-proton collision data, corresponding to an integrated luminosity of 6 $fb^{-1}$, collected with the LHCb detector at a center-of-mass energy of 13 TeV. Using a sample of approximately 349 000 $B^{0}_{s}$ signal decays with an invariant $K^{+}K^{-}$ mass in the vicinity of the $\phi(1020)$ resonance, the $CP$-violating phase $\phi_s$ is measured, along with the difference in decay widths of the light and heavy mass eigenstates of the $B^0_s$-$\bar{B}^0_s$ system, $\Delta\Gamma_s$, and the difference of the average $B^0_s$ and $B^0$ meson decay widths, $\Gamma_s-\Gamma_d$. The values obtained are $\phi_s = \ -0.039 \pm 0.022 \pm 0.006$ rad, $\Delta\Gamma_s = 0.0845 \pm 0.0044 \pm 0.0024$ ps$^{-1}$ and $\Gamma_s-\Gamma_d = -0.0056 ^{+ 0.0013}_{-0.0015} \pm 0.0014$ ps$^{-1}$, where the first uncertainty is statistical and the second systematic. These are the most precise single measurements to date and are consistent with expectations based on the Standard Model and with the previous LHCb analyses of this decay. These results are combined with previous independent LHCb measurements. The phase $\phi_s$ is also measured independently for each polarization state of the $K^{+}K^{-}$ system and shows no evidence for polarization dependence

Measurement of prompt D+D^+ and Ds+D^+_{s} production in pPbp\mathrm{Pb} collisions at sNN=5.02 \sqrt {s_{\mathrm{NN}}}=5.02\,TeV

International audienceThe production of prompt $D^+$ and $D^+_{s}$ mesons is studied in proton-lead collisions at a centre-of-mass energy of $\sqrt {s_{\mathrm{NN}}}=5.02\,$TeV. The data sample corresponding to an integrated luminosity of $(1.58\pm0.02)\mathrm{nb}^{-1}$ is collected by the LHCb experiment at the LHC. The differential production cross-sections are measured using $D^+$ and $D^+_{s}$ candidates with transverse momentum in the range of $0<p_{\mathrm{T}} <14\,\mathrm{GeV}/c$ and rapidities in the ranges of $1.5<y^*<4.0$ and $-5.0<y^*<-2.5$ in the nucleon-nucleon centre-of-mass system. For both particles, the nuclear modification factor and the forward-backward production ratio are determined. These results are compared with theoretical models that include initial-state nuclear effects. In addition, measurements of the cross-section ratios between $D^+$, $D^+_{s}$ and $D^0$ mesons are presented, providing a baseline for studying the charm hadronization in lead-lead collisions at LHC energies

Observation of Ξb0→Ξc+Ds−\Xi_b^0 \rightarrow \Xi_c^+ D_s^- and Ξb−→Ξc0Ds−\Xi_b^- \rightarrow \Xi_c^0 D_s^- decays

International audienceThe $\Xi_b^0 \rightarrow \Xi_c^+ D_s^-$ and $\Xi_b^- \rightarrow \Xi_c^0 D_s^-$ decays are observed for the first time using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of $\sqrt{s}=13\mathrm{TeV}$, corresponding to an integrated luminosity of $5.1\mathrm{fb}^{-1}$. The relative branching fractions times the beauty-baryon production cross-sections are measured to be \begin{align*} \mathcal{R}\left(\frac{\Xi_b^0}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^0\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^0 \rightarrow \Xi_c^+ D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(15.8\pm1.1\pm0.6\pm7.7)\%, \mathcal{R}\left(\frac{\Xi_b^-}{\Lambda_b^0}\right) \equiv \frac{\sigma\left(\Xi_b^-\right)}{\sigma\left(\Lambda_b^0\right)} \times \frac{\mathcal{B}\left(\Xi_b^- \rightarrow \Xi_c^0 D_s^-\right)}{\mathcal{B}\left(\Lambda_b^0 \rightarrow \Lambda_c^0 D_s^-\right)} =(16.9\pm1.3\pm0.9\pm4.3)\%, \end{align*} where the first uncertainties are statistical, the second systematic, and the third due to the uncertainties on the branching fractions of relevant charm-baryon decays. The masses of $\Xi_b^0$ and $\Xi_b^-$ baryons are measured to be $m_{\Xi_b^0}=5791.12\pm0.60\pm0.45\pm0.24\mathrm{MeV}/c^2$ and $m_{\Xi_b^-}=5797.02\pm0.63\pm0.49\pm0.29\mathrm{MeV}/c^2$, where the uncertainties are statistical, systematic, and those due to charm-hadron masses, respectively

Measurement of CP violation in B0→ψ(→ℓ+ℓ−)KS0(→π+π−)B^0\to\psi(\to\ell^+\ell^-)K^0_S(\to\pi^+\pi^-) decays

International audienceA measurement of time-dependent CP violation in the decays of $B^0$ and $\overline{B}^0$ mesons to the final states $J/\psi(\to\mu^+\mu^-)K^0_S$, $\psi(2S)(\to\mu^+\mu^-)K^0_S$ and $J/\psi(\to e^+e^-)K^0_S$ with $K^0_S\to\pi^+\pi^-$ is presented. The data correspond to an integrated luminosity of 6 fb${}^{-1}$ collected at a centre-of-mass energy of $\sqrt{s}=13$ TeV with the LHCb detector. The CP-violation parameters are measured to be \begin{align*} S_{\psi K^0_S} &= 0.717 \pm 0.013 (\text{stat}) \pm 0.008 (\text{syst}), \\ C_{\psi K^0_S} &= 0.008 \pm 0.012 (\text{stat}) \pm 0.003 (\text{syst}). \end{align*} This measurement of $S_{\psi K^0_S}$ represents the most precise single measurement of the CKM angle $\beta$ to date and is more precise than the current world average. In addition, measurements of the CP-violation parameters of the individual channels are reported and a combination with the LHCb Run 1 measurements is performed

Search for CPCP violation in the phase space of D0→π−π+π0D^0 \to \pi^-\pi^+\pi^0 decays with the energy test

International audienceA search for $CP$ violation in $D^0 \to \pi^-\pi^+\pi^0$ decays is reported, using $pp$ collision data collected by the LHCb experiment from 2015 to 2018 corresponding to an integrated luminosity of 6$fb^{-1}$. An unbinned model-independent approach provides sensitivity to local $CP$ violation within the two-dimensional phase space of the decay. The method is validated using the Cabibbo-favoured channel \D^0 \to \K^-\pi^+\pi^0 and background regions of the signal mode. The results are consistent with $CP$ symmetry in this decay

Helium identification with LHCb

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using $pp$ collision data at $\sqrt{s}=13\,{\rm TeV}$ recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of $5.5\,{\rm fb}^{-1}$. A total of around $10^5$ helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately $50\%$ with a corresponding background rejection rate of up to $\mathcal O(10^{12})$. These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei

Study of Bc+→χcπ+B_c^+ \rightarrow \chi_c \pi^+ decays

International audienceA study of $B_c^+ \rightarrow \chi_c \pi^+$ decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9fb$^{-1}$. The decay $B_c^+ \rightarrow \chi_{c2} \pi^+$ is observed for the first time, with a significance exceeding seven standard deviations. The relative branching fraction with respect to the $B_c^+ \rightarrow J/\psi \pi^+$ decay is measured to be $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow J/\psi \pi^+}} = 0.37 \pm 0.06 \pm 0.02 \pm 0.01 ,$$ where the first uncertainty is statistical, the second is systematic, and the third is due to the knowledge of the $\chi_c \rightarrow J/\psi \gamma$ branching fraction. No significant $B_c^+ \rightarrow \chi_{c1} \pi^+$ signal is observed and an upper limit for the relative branching fraction for the $B_c^+ \rightarrow \chi_{c1} \pi^+$ and $B_c^+ \rightarrow \chi_{c2} \pi^+$ decays of $$\frac{\mathcal{B}_{B_c^+ \rightarrow \chi_{c1} \pi^+}} {\mathcal{B}_{B_c^+ \rightarrow \chi_{c2} \pi^+}} < 0.49$$ is set at the 90% confidence level

Observation of Λb0→Λc+Dˉ(∗)0K−\Lambda_{b}^{0} \to \Lambda_{c}^{+} \bar{D}^{(*)0} K^{-} and Λb0→Λc+Ds∗−\Lambda_{b}^{0} \to \Lambda_{c}^{+} D_{s}^{*-} decays

International audienceThe decays $\Lambda_b^0 \to \Lambda_c^+\bar{D}^{(*)0}K^-$ and $\Lambda_b^0 \to \Lambda_c^+ D_s^{*-}$ are observed for the first time, in proton-proton collision data at $\sqrt{s}=13$TeV corresponding to an integrated luminosity of 5.4 fb${}^{-1}$ collected with the LHCb detector. Their ratios of branching fractions with respect to the $\Lambda_b^0\!\to\Lambda_c^+\mathrm{D}_s^-$ mode are measured to be \begin{align*} \begin{split} \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\bar{D}^0 K^-)}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 0.1908 {}_{-0.0034}^{+0.0036} {}_{-0.0018}^{+0.0016} \pm 0.0038 \\ \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+\bar{D}^{*0} K^-)}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 0.589 {}_{-0.017}^{+0.018} {}_{-0.018}^{+0.017} \pm 0.012 \\ \frac{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^{*-})}{\mathcal{B}(\Lambda_b^0 \to \Lambda_c^+ D_s^-)} & = 1.668 \pm 0.022 {}_{-0.055}^{+0.061}\ , \end{split} \end{align*} where the first uncertainties are statistical, the second systematic, and the third, for the $\Lambda_b^0 \to \Lambda_c^+ \bar{D}^{(*)0} K^-$ decays, are due to the uncertainties on the branching fractions of the $D_s^- \to K^- K^+ \pi^-$ and $\bar{D}^0 \to K^+\pi^-$ decay modes. The measured branching fractions probe factorization assumptions in effective theories and provide the normalization for future pentaquark searches in $\Lambda_b^0 \to \Lambda_c^+ \bar{D}^{(*)0}K^-$ decay channels

Determination of short- and long-distance contributions in B0→K∗0μ+μ−B^{0}\to K^{*0}\mu^+\mu^- decays

International audienceAn amplitude analysis of the $B^0 \to K^{*0} \mu^+\mu^-$ decay is presented. The analysis is based on data collected by the LHCb experiment from proton-proton collisions at $\sqrt{s} = 7,\,8$ and $13$ TeV, corresponding to an integrated luminosity of $4.7$ fb$^{-1}$. For the first time, Wilson coefficients and non-local hadronic contributions are accessed directly from the unbinned data, where the latter are parameterised as a function of $q^2$ with a polynomial expansion. Wilson coefficients and non-local hadronic parameters are determined under two alternative hypotheses: the first relies on experimental information alone, while the second one includes information from theoretical predictions for the non-local contributions. Both models obtain similar results for the parameters of interest. The overall level of compatibility with the Standard Model is evaluated to be between 1.8 and 1.9 standard deviations when looking at the $\mathcal{C}_9$ Wilson coefficient alone, and between 1.3 and 1.4 standard deviations when considering the full set of $\mathcal{C}_9, \, \mathcal{C}_{10}, \, \mathcal{C}_9^\prime$ and $\mathcal{C}_{10}^\prime$ Wilson coefficients. The ranges reflect the theoretical assumptions made in the analysis