Pengaruh Motivasi terhadap Kinerja Pegawai (Studi pada Kantor Kecamatan Ratahan Kabupaten Minahasa Tenggara)

Southeast Minahasa Regency is the Effect of Motivation on Employee Performance is still notcontributed optimally. Factors that affect employee motivation, among others, job satisfactionand the amount recived by an employee kompensasi. To do a job, the employee should have ahigh performance. Therefore, it is necessary to effect a good motivation in order to improve theperformance of the employees.Motivation is the driving goal, the real goal being the main driving force for a person toattempt to obtain or achieve what he wanted either positive or negative. Performance is the resultof the quality and quantity of work achieved by a person in performing its functions inaccordance with the responsibilities given to the employees. The purpose of this study was todetermine the motivation is there any influence on the performance of employees at the DistrictOffice Ratahan Southeast Minahasa Regency.In this study, the method used is quantitative analysis method. While data analysistechnique used is the technique of correlation between variables to prove the effect of motivationon employee performance. Based on the results of research conducted and followed by analyzingthe data obtained, then the result is that there is a strong relationship between the effect ofmotivation on employee performance for 0.665%, this means working hypothesis acceptablealternative. The result were obtained coefficient determinant of the remaining 44.22%, 55.78%more influenced by other factors not included in this study

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3‑Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

A highly enantioselective 1,3-dipolar cycloaddition of imino esters with methyleneindolinones has been realized by using readily available thiourea–quaternary ammonium salts as phase-transfer catalysts, enabling efficient construction of a range of chiral spiro­[pyrrolidin-3,3′-oxindoles] in good yields with excellent enantioselectivities under mild conditions

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3‑Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

A highly enantioselective 1,3-dipolar cycloaddition of imino esters with methyleneindolinones has been realized by using readily available thiourea–quaternary ammonium salts as phase-transfer catalysts, enabling efficient construction of a range of chiral spiro­[pyrrolidin-3,3′-oxindoles] in good yields with excellent enantioselectivities under mild conditions

Additional file 1: Table S1. of Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway

The clinicopathologic characteristics of the 112 GC patients who received surgery followed by adjuvant chemotherapy in this study. (DOC 40 kb

ULK1: A Promising Biomarker in Predicting Poor Prognosis and Therapeutic Response in Human Nasopharygeal Carcinoma

<div><p>Plenty of studies have established that dysregulation of autophagy plays an essential role in cancer progression. The autophagy-related proteins have been reported to be closely associated with human cancer patients’ prognosis. We explored the expression dynamics and prognostic value of autophagy-related protein ULK1 by immunochemistry (IHC) method in two independent cohorts of nasopharygeal carcinoma (NPC) cases. The X-tile program was applied to determine the optimal cut-off value in the training cohort. This derived cutoff value was then subjected to analysis the association of ULK1 expression with patients’ clinical characteristics and survival outcome in the validation cohort and overall cases. High ULK1 expression was closely associated with aggressive clinical feature of NPC patients. Furthermore, high expression of ULK1 was observed more frequently in therapeutic resistant group than that in therapeutic effective group. Our univariate and multivariate analysis also showed that higher ULK1 expression predicted inferior disease-specific survival (DSS) (P<0.05). Consequently, a new clinicopathologic prognostic model with 3 poor prognostic factors (ie, ULK1 expression, overall clinical stage and therapeutic response) could significantly stratify risk (low, intermediate and high) for DSS in NPC patients (P<0.001). These findings provide evidence that, the examination of ULK1 expression by IHC method, could serve as an effective additional tool for predicting therapeutic response and patients’ survival outcome in NPC patients.</p></div

The predictive value of ULK1 expression regarding NPC patients’ treatment response.

<p>Receiver operating characteristic curve analysis for ULK1 expression was performed to assess NPC treatment response in the training cohort (AUC = 0.643, P<0.001) (A) and in the validation cohort (AUC = 0.699, P<0.001) (B).</p

The association of ULK1 expression with clinicopathological variables.

<p>a Mean age</p><p>b Chi-square test</p><p>RT, radiotherapy; CR, complete response; Non-CR (including PR, partial response; NC, no change; PD, progressive disease); IC, induction chemotherapy; RCT, radiochemotherapy</p><p>*Statistically significant difference</p><p>The association of ULK1 expression with clinicopathological variables.</p

Results of multivariate Cox proportional-hazards analysis for disease-specific survival for NPC patients.

<p>Cox propotional hazard regression model, enter; HR, Hazard ratio; CI, confidence interval; CR, complete response, Non-CR (including PR, partial response; NC, no change; PD, progressive disease)</p><p>*Statistically significant difference</p><p>Results of multivariate Cox proportional-hazards analysis for disease-specific survival for NPC patients.</p

Univariate analysis of ULK1 expression and various clinicopathological parameters in validation and overall cases of NPC patients.

<p>a Mean age.</p><p>Cox propotional hazard regression model, enter; HR, Hazard ratio; CI, confidence interval; CR, complete response, Non-CR (including PR, partial response; NC, no change; PD, progressive disease)</p><p>*Statistically significant difference</p><p>Univariate analysis of ULK1 expression and various clinicopathological parameters in validation and overall cases of NPC patients.</p

The association between ULK1 expression and NPC patients’ survival.

<p>Kaplan-Meier survival analysis of ULK1 expression for disease-specific survival in the validation cohort (A) and in the overall cases (B) (log-rank test).</p