Nanomechanical behavior of biodegradable metallic glass for transient electrodes

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硬化後および焼却後のリン酸塩系埋没材の気孔率に対するコロイダルシリカ懸濁液の効果

A numerical simulation model, which was based on the setting and heating reactions of the binder phase of phosphate-bonded investment compacts, was developed to compute the porosities of set and burnout compacts. Densities and concentrations of microsilica particles in dilute suspension were measured and input into the simulation model. Validity of the model was confirmed by experimental results, that is, colloidal silica suspensions were prepared using different silica concentrations and mixed with investment powders. Porosities of these set and burnout compacts were experimentally measured. Effects of these factors on the porosity of compacts were examined using the developed simulation model: liquid/powder (L/P) ratio, concentration of microsilica particles in colloidal silica suspension, and ratio of binder component (NH4H2PO4) in investment powder. It was concluded that numerical simulation is a viable tool for dental materials research

The Correlation between Climate Change and Corporate Performance

38-43The purpose of the study is to verify the correlation of the climate change risk focusing on the influence of carbon emission on the corporate performance and discriminative response of corporate contingent upon the publishment of Sustainability Report. The results of this study show that there is a negative (-) relationship between Carbon emission intensity and corporate performance. And the negative influence of carbon emission intensity on corporate performance was found to be smaller for companies that published sustainability reports than for those that did not. This study provided empirical evidences on why corporate’s active reactive activities according to the climate change is essential for sustainable development

Complete mitochondrial genome sequence of the Indian pipistrelle Pipistrellus coromandra (Vespertilioninae)

We characterized the complete mitogenome of Pipistrellus coromandra (Indian pipistrelle) for comparative analysis of mitogenomes and for resolving the phylogenetic relationship of four tribes in the subfamily Vespertilioninae. The mitogenome size of P. coromandra was 17,153 bp, with a control region and a typical set of 37 mitochondrial genes. The nucleotide composition of the P. coromandra mitogenome showed an AT bias with a nucleotide composition of 33.5% A, 30.7% T, 13.3% G, and 22.5% C. The mitochondrial protein-coding genes in P. coromandra use the standard start codon (ATN), two stop codons (TAA and AGA), and two incomplete stop codons (TA- and T--). The intertribal relationship of four tribes was highly resolved from the phylogenetic analysis of mitogenome sequences

Treatment of non-odontogenic orofacial pain using botulinum toxin-A: a retrospective case series study

Background The purpose of this study was to evaluate the clinical outcomes of treatment of non-odontogenic atypical orofacial pain using botulinum toxin-A. Methods This study involved seven patients (seven females, mean age 65.1 years) who had non-odontogenic orofacial pain (neuropathic pain and atypical orofacial pain) and visited the Seoul National University Bundang Hospital between 2015 and 2017. All medication therapies were preceded by botulinum toxin-A injections, followed by injections in the insignificant effects of medication therapies. Five of the seven patients received intraoral injections in the gingival vestibule or mucosa, while the remaining two received extraoral injections in the masseter and temporal muscle areas. Results In five of the seven patients, pain after botulinum toxin-A injection was significantly reduced. Most of the patients who underwent surgery for dental implantation or facial nerve reconstruction recovered after injections. However, the pain did not disappear in two patients who reported experiencing persistent pain without any cause. Conclusions The use of botulinum toxin-A for the treatment of non-odontogenic neuropathic orofacial pain is clinically useful. It is more effective to administer botulinum toxin-A in combination with other medications and physical therapy to improve pain

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1

Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment. Several drugs have targeted HSPs, since cancer cells are known to hijack these helper proteins to shield themselves from destruction by the body. However, the drugs have had limited success. Hye-Kyung Park and Byoung Heon Kang at Ulsan National Institutes of Science and Technology in South Korea and coworkers noticed that the drugs were not absorbed into mitochondria, a key cellular compartment, and HSPs in this compartment were therefore not being blocked. They identified a new HSP inhibitor that can reach every cellular compartment and inhibit all HSPs. Testing in mice showed that this inhibitor effectively triggered death of tumor cells, and therefore shows promise for anti-cancer therapy. The Hsp90 family proteins Hsp90, Grp94, and TRAP1 are present in the cell cytoplasm, endoplasmic reticulum, and mitochondria, respectively; all play important roles in tumorigenesis by regulating protein homeostasis in response to stress. Thus, simultaneous inhibition of all Hsp90 paralogs is a reasonable strategy for cancer therapy. However, since the existing pan-Hsp90 inhibitor does not accumulate in mitochondria, the potential anticancer activity of pan-Hsp90 inhibition has not yet been fully examined in vivo. Analysis of The Cancer Genome Atlas database revealed that all Hsp90 paralogs were upregulated in prostate cancer. Inactivation of all Hsp90 paralogs induced mitochondrial dysfunction, increased cytosolic calcium, and activated calcineurin. Active calcineurin blocked prosurvival heat shock responses upon Hsp90 inhibition by preventing nuclear translocation of HSF1. The purine scaffold derivative DN401 inhibited all Hsp90 paralogs simultaneously and showed stronger anticancer activity than other Hsp90 inhibitors. Pan-Hsp90 inhibition increased cytotoxicity and suppressed mechanisms that protect cancer cells, suggesting that it is a feasible strategy for the development of potent anticancer drugs. The mitochondria-permeable drug DN401 is a newly identified in vivo pan-Hsp90 inhibitor with potent anticancer activity

The Correlation between Climate Change and Corporate Performance

The purpose of the study is to verify the correlation of the climate change risk focusing on the influence of carbon emission on the corporate performance and discriminative response of corporate contingent upon the publishment of Sustainability Report. The results of this study show that there is a negative (-) relationship between Carbon emission intensity and corporate performance. And the negative influence of carbon emission intensity on corporate performance was found to be smaller for companies that published sustainability reports than for those that did not. This study provided empirical evidences on why corporate’s active reactive activities according to the climate change is essential for sustainable developmen