Results of Endoscopic Dacryocystorhinostomy under Local Anesthesia with Minimal Sedation

Purpose. We evaluated the tolerability and efficacy of endoscopic dacryocystorhinostomy (Endo-DCR) in patients treated in the leaning position and under local anesthesia with minimal sedation (LAS). Study Design. Questionnaire to determine subjective success of Endo-DCR. Methods. From May 2013 to August 2014, a total of 95 eyes with epiphora presented to the Myoung Eye Plastic Surgery Clinic in Seoul, Korea, and were treated with Endo-DCR under LAS. Three nerve blocks were administered to achieve local anesthesia. Postoperatively, the wound site was packed with Nasopore to control bleeding and promote wound healing. Outcome measures included a patient questionnaire completed on postoperative day 7 to evaluate intraoperative and postoperative pain based on the VAS (0 to 10). Results. Mean intraoperative and postoperative pain scores were 1.03 and 1.64, respectively, for 95 eyes. Of the 95 eyes treated, the patients in 82 eyes (86.31%) reported that they would prefer LAS over GA for a repeat Endo-DCR. The subjective and objective surgical success rates were 90.14% and 95.77%, respectively. Conclusions. Endo-DCR carried out under LAS with the patient in the leaning position is more useful, efficient, and feasible than Endo-DCR performed under GA with the patient in the supine position

Frontoethmoidal Mucocele Presenting as Progressive Enophthalmos

In this case report we describe a 27-year-old man who presented with progressive enophthalmos for 5 months without any other associated ocular symptoms such as pain, diplopia, or visual disturbance. Computed tomography showed that his progressive enophthalmos originated from a frontoethmoidal mucocele and this caused destruction of the lamina papyracea and shrinkage of the ethmoidal air cell. Finally the enlarged orbital space caused an inward deviation of the eyeball. Endoscopic marsupialization was successfully performed by an otolaryngologist and did not result in any ophthalmologic sequelae. Although frontoethmoidal sinus mucoceles mostly frequently originates from orbital mucoceles, enophthalmic manifestations are very rare. Enophthalmic conditions are not as responsive to surgical interventions as exophthalmic conditions

악성림프종에서 SV40 Large T Antigen의 검색

Background : The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is distributed worldwide, its incidences vary according to the specific types of tumors, and the epidemiological areas. The aim of this study was to investigate the frequency of SV40 in malignant lymphomas among Korean patients. Methods : One hundred seventy three cases of malignant lymphomas were evaluated by immunohistochemical staining for SV40 large T antigen (TAg), using an extremely sensitive, tyramide based, catalyzed signal amplification method. Results: From 158 non-Hodgkin`s lymphomas, including 115 diffuse large B-cell lymphomas, and 15 Hodgkin`s lymphomas, none of the cases were positive for SV40 TAg. Conclusions : SV40 does not appear to be related to the pathogenesis of malignant lymphomas among Koreans.Amara K, 2007, INT J CANCER, V121, P2693, DOI 10.1002/ijc.23038Lee HS, 2007, CLIN CANCER RES, V13, P4154, DOI 10.1158/1078-0432.CCR-07-0173Shah KV, 2007, INT J CANCER, V120, P215, DOI 10.1002/ijc.22425Vilchez RA, 2006, HUM PATHOL, V37, P1130, DOI 10.1016/j.humpath.2006.04.020Doerries K, 2006, ADV EXP MED BIOL, V577, P102Vilchez RA, 2005, VIROLOGY, V342, P38, DOI 10.1016/j.virol.2005.06.053Paik JH, 2005, HISTOPATHOLOGY, V47, P281, DOI 10.1111/j.1365-2559.2005.02222.xSui LF, 2005, PATHOLOGY, V37, P157, DOI 10.1080/00313020500058474Heinsohn S, 2005, HAEMATOLOGICA, V90, P94VILCHEZ RA, 2005, HAEMATOLOGICA, V90, P6Jin M, 2004, J MED VIROL, V74, P668Brousset P, 2004, INT J CANCER, V112, P533, DOI 10.1002/IJC.20397Barbanti-Brodano G, 2004, VIROLOGY, V318, P1, DOI 10.1016/j.virol.2003.09.004Nakatsuka S, 2003, CANCER RES, V63, P7606MacKenzie J, 2003, J NATL CANCER I, V95, P1001Vilchez RA, 2003, AM J MED, V114, P675, DOI 10.1016/S002-9343(03)0087-1Chang MS, 2003, J PATHOL, V199, P447, DOI 10.1002/path.1302Vivaldi A, 2003, J CLIN ENDOCR METAB, V88, P892, DOI 10.1210/jc.2002-020436STRATTON K, 2003, IMMUNIZATION SAFETYVilchez RA, 2002, LANCET, V359, P817Shivapurkar N, 2002, LANCET, V359, P851JAFFE E, 2001, PATHOLOGY GENETICS TMartini F, 1998, INT J CANCER, V78, P669NUMA F, 1995, CANCER RES, V55, P4676GLUZMAN Y, 1981, CELL, V23, P175ONEILL FJ, 1981, VIROLOGY, V112, P800FRAUMENI JF, 1963, JAMA-J AM MED ASSOC, V185, P713

Interaction between the p75 neurotrophin receptor and a novel adaptor protein

The neurotrophin plays an important role in the development, differentiation and survival of the nervous system in vertebrates. It exerts its cellular effects through two different receptors, the Trk receptor tyrosine kinase neurotrophin receptor and the p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily. Trk and p75 neurotrophin receptors utilize specific target proteins to transmit signals into the cell. An ankyrin-rich membrane spanning protein (ARMS) was identified as a new p75 interacting protein and serves as a novel downstream target of p75 neurotrophin receptor. We sought to delineate the interaction between p75 and ARMS by deletion constructs of p75 and green fluorescent protein (GFP)-tagged ARMS. We examined the interaction between these two proteins after overexpressing them in HEK-293 cells. Using both Western blot analysis and immunocytochemistry followed by confocal laser scanning microscopy, we found out that the intracellular domain of the p75 neurotrophin receptor was important for the interaction with ARMS. The results from this study suggest that ARMS may play an important role for mediating the signals from p75 neurotrophin receptor into the cell