6,085 research outputs found
Life fingerprints of nuclear reactions in the body of animals
Nuclear reactions are a very important natural phenomenon in the universe. On the earth, cosmic rays constantly cause nuclear reactions. High energy beams created by medical devices also induce nuclear reactions in the human body. The biological role of these nuclear reactions is unknown. Here we show that the in vivo biological systems are exquisite and sophisticated by nature in influence on nuclear reactions and in resistance to radical damage in the body of live animals. In this study, photonuclear reactions in the body of live or dead animals were induced with 50-MeV irradiation. Tissue nuclear reactions were detected by positron emission tomography (PET) imaging of the induced beta+ activity. We found the unique tissue "fingerprints" of beta+ (the tremendous difference in beta+ activities and tissue distribution patterns among the individuals) are imprinted in all live animals. Within any individual, the tissue "fingerprints" of 15O and 11C are also very different. When the animal dies, the tissue "fingerprints" are lost. The biochemical, rather than physical, mechanisms could play a critical role in the phenomenon of tissue "fingerprints". Radiolytic radical attack caused millions-fold increases in 15O and 11C activities via different biochemical mechanisms, i.e. radical-mediated hydroxylation and peroxidation respectively, and more importantly the bio-molecular functions (such as the chemical reactivity and the solvent accessibility to radicals). In practice biologically for example, radical attack can therefore be imaged in vivo in live animals and humans using PET for life science research, disease prevention, and personalized radiation therapy based on an individual's bio-molecular response to ionizing radiation
Effect of additive calcium administration on FGF23 levels in patients with mild chronic kidney disease treated with calcitriol: a randomized, open-labeled clinical trial
Lack of evidence of hepatitis in patients with oral lichen planus in China: a case control study
Background: China has been one of the countries with high prevalence of chronic hepatitis B virus (HBV) and
hepatitis C virus (HCV) liver disease. And lichen planus is an extrahepatic manifestation of patients with chronic
HCV infection. This case-control study was conducted to investigate the relationship between oral lichen planus
(OLP) and HBV/HCV infection in China.
Material and Methods: A total of 776 patients, including 150 patients with OLP (Group OLP), 429 inpatients from
the Trauma Ward of Oral and Maxillofacial Surgery Department (Group A), 110 patients with other oral mucosal
diseases, but without a reported association with HCV infection (Group B) and 87 patients with oral lichenoid lesion
(Group OLL), were compared with their seroprevalence of anti-HCV antibody (HCVAb), hepatitis B surface
antigen (HBsAg) and the parameters of liver functions. Moreover, the clinical characteristics of OLP were also
observed, such as gender, age, chief complaint, course of the disease, clinical type, sites involved and so on.
Results: The positive rates of HCVAb and HBsAg in OLP patients were 0.7% and 4%, respectively. Neither HCVAb
nor HBsAg was associated with OLP as demonstrated by both the univariate and the multivariate analyses.
The clinical features and liver functions of OLP patients with negative or positive HBsAg were nearly the same.
Conclusions: Our findings verify that there is no association between OLP and hepatitis and there is no need to run
a screening test for HCV or HBV in OLP patients in Chin
Vocal cord dysfunction diagnosed by four-dimensional dynamic volume computed tomography in patients with difficult-to-treat asthma: A case series
Patients with asthma may also have vocal cord dysfunction (VCD), which leads to poor control of the asthma. Once patients are diagnosed with difficult-to-treat asthma with poor control, VCD should be excluded or treated accordingly. The gold standard for diagnosis of VCD is to perform a laryngoscopy. However, this procedure is invasive and may not be suitable for patients with difficult-to-treat asthma. Four-dimensional (4D) dynamic volume computed tomography (CT) is a noninvasive method for quantification of laryngeal movement, and can serve as an alternative for the diagnosis of VCD. Herein, we present a series of five cases with difficult-to-treat asthma patients who were diagnosed with VCD by 4D dynamic volume CT. Clinicians should be alert to the possibility of VCD when poor control is noted in patients with asthma. Early diagnosis by noninvasive 4D dynamic volume CT can decrease excessive doses of inhaled corticosteroids
Experimental Investigation on the ICCP-SS Technique for Sea-Sand RC Beams
Impressed current cathodic protection (ICCP) is an efficient method to prevent further corrosion of the re-bars, while strengthening structures (SS) by using carbon fiber mesh can help improve the loading capacity of the degraded sea-sand reinforced concrete (RC) structures. This study proposes a new dual-functional method, ICCP-SS, to retrofit the sea-sand RC structures by using the carbon - fiber reinforced cementitious matrix (C-FRCM). The C-FRCM composite, comprised of carbon fiber mesh and inorganic cementitious material, is both the anodic material in the ICCP process as well as the structural strengthening material. This paper presents an experimental program consisting of 11 simply supported beams, 10 of them casted by simulated sea-sand and subjected to accelerated corrosion process for 130 days. The specimens casted by sea-sand were afterwards bonded with C-FRCM composite, treated by ICCP for 130 days, and finally tested. In this study, the flexure strength of the beams, the deflection and curvature of the specimens, as well as the strain and the open circuit potential of re-bars are obtained and used to assess the performance of the repaired specimens. The proposed technique has been shown to be effective in retarding the corrosion of re-bars and recovering the loading capacity of the corroded specimens, which should be beneficial for the durability of sea-sand RC structures
Impact of Pneumocystis jirovecii pneumonia on kidney transplant outcome
Backgrounds
Pneumocystis jirovecii pneumonia (PCP) remains an important cause of morbidity and mortality in kidney transplant recipients. While the acute phase toxicity in patients with PCP is well-characterized, there is a lack of data on the effects of PCP on long-term graft outcome.
Method
This retrospective observational study analyzed 1502 adult patients who underwent kidney transplantation at Seoul National University Hospital between 2000 and 2017. After a propensity score matching was performed, the graft and survival outcomes were compared between PCP-negative and PCP-positive groups.
Results
A total of 68 patients (4.5%) developed PCP after transplantation. The multivariable Cox analysis showed that positivity for cytomegalovirus and lack of initial oral antibiotic prophylaxis were risk factors of post-transplant PCP. The PCP-positive group had higher hazard ratios of graft failure [adjusted hazard ratio (HR), 3.1 (1.14–8.26); P = 0.027] and mortality [adjusted HR, 11.0 (3.68–32.80); P < 0.001] than the PCP-negative group. However, the PCP event was not related with subsequent development of de novo donor-specific antibodies or pathologic findings, such as T-cell or antibody mediated rejection and interstitial fibrosis and tubular atrophy.
Conclusions
PCP is a risk factor of long-term graft failure and mortality, irrespective of rejection. Accordingly, appropriate prophylaxis and treatment is needed to avoid adverse transplant outcomes of PCP.This study was supported by the Young Investigator Research Grant from the Korean Society Nephrology (Kyowa Hakko Kirin 2017) and a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (NRF-2017R1D1A1B03031642). The grants had neither role in the study design, nor in data collection, analysis, interpretation and nor in manuscript writing
The changes of cardiac energy metabolism with sodium-glucose transporter 2 inhibitor therapy
Background/aimsTo investigate the specific effects of s
odium-glucose transporter 2 inhibitor (SGLT2i) on cardiac energy metabolism.MethodsA systematic literature search was conducted in eight databases. The retrieved studies were screened according to the inclusion and exclusion criteria, and relevant information was extracted according to the purpose of the study. Two researchers independently screened the studies, extracted information, and assessed article quality.ResultsThe results of the 34 included studies (including 10 clinical and 24 animal studies) showed that SGLT2i inhibited cardiac glucose uptake and glycolysis, but promoted fatty acid (FA) metabolism in most disease states. SGLT2i upregulated ketone metabolism, improved the structure and functions of myocardial mitochondria, alleviated oxidative stress of cardiomyocytes in all literatures. SGLT2i increased cardiac glucose oxidation in diabetes mellitus (DM) and cardiac FA metabolism in heart failure (HF). However, the regulatory effects of SGLT2i on cardiac FA metabolism in DM and cardiac glucose oxidation in HF varied with disease types, stages, and intervention duration of SGLT2i.ConclusionSGLT2i improved the efficiency of cardiac energy production by regulating FA, glucose and ketone metabolism, improving mitochondria structure and functions, and decreasing oxidative stress of cardiomyocytes under pathological conditions. Thus, SGLT2i is deemed to exert a benign regulatory effect on cardiac metabolic disorders in various diseases.Systematic review registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42023484295)
Discrimination of Kawasaki disease with concomitant adenoviral detection differentiating from isolated adenoviral infection
PurposeHuman adenovirus infection mimics Kawasaki disease (KD) but can be detected in KD patients. The aim of this study was to determine the clinical differences between KD with adenovirus infection and only adenoviral infection and to identify biomarkers for prediction of adenovirus-positive KD from isolated adenoviral infection.MethodsA total of 147 patients with isolated adenovirus were identified by quantitative polymerase chain reaction. In addition, 11 patients having KD with adenovirus, who were treated with intravenous immunoglobulin therapy during the acute phase of KD were also evaluated.ResultsCompared with the adenoviral infection group, the KD with adenovirus group was significantly associated with frequent lip and tongue changes, skin rash and changes in the extremities. In the laboratory parameters, higher C-reactive protein (CRP) level and presence of hypoalbuminemia and sterile pyuria were significantly associated with the KD group. In the multivariate analysis, lip and tongue changes (odds ratio [OR], 1.416; 95% confidence interval [CI], 1.151–1.741; P=0.001), high CRP level (OR, 1.039; 95% CI 1.743–1.454; P= 0.021) and sterile pyuria (OR 1.052; 95% CI 0.861–1.286; P=0.041) were the significant predictive factors of KD. In addition, the cutoff CRP level related to KD with adenoviral detection was 56 mg/L, with a sensitivity of 81.8% and a specificity of 75.9%.ConclusionLip and tongue changes, higher serum CRP level and sterile pyuria were significantly correlated with adenovirus-positive KD
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