Vulnerability Analysis of Soft Caving Tunnel Support System and Surrounding Rock Optimal Control Technology Research

The vulnerability assessment model, composed by 11 vulnerability factors, is established with the introduction of the concept of “vulnerability” into the assessment of tunnel support system. Analytic hierarchy process is utilized to divide these 11 factors into human attributes and natural attributes, and define the weight of these factors for the model. The “vulnerability” applied io the assessment of the tunnel support system model is reached. The vulnerability assessment model was used for evaluating and modifying the haulage tunnel #3207 of Bo-fang mine panel #2. The results decreased the vulnerability of the tunnel support system and demonstrated acceptable effects. Furthermore, the results show that the impact of human attributes on tunnel support systems is dramatic under the condition that natural attributes are permanent, and the “vulnerability” is exactly a notable factor to manifest the transformation during this process. The results also indicate that optimizing human attributes can attenuate vulnerability in tunnel support systems. As a result, enhancement of stability of tunnel support systems can be achieved

Nanomedicine for treating spinal cord injury

Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. Nanomaterials can be used to provide effective treatments; their unique properties can facilitate drug delivery to the injury site, enact as neuroprotective agents, or provide platforms to stimulate regrowth of damaged tissues. We review recent uses of nanomaterials including nanowires, micelles, nanoparticles, liposomes, and carbon-based nanomaterials for neuroprotection in the acute phase. We also review the design and neural regenerative application of electrospun scaffolds, conduits, and self-assembling peptide scaffolds

Arbitrary Shape Electromagnetic Transparent Device Based on Laplace’s Equation

Transparent device is deliberately-designed electromagnetic structure that is transparent to electromagnetic wave. It can be used as a radome structure which is capable of protection antenna inside without sacrificing its performance. In this paper, two-dimensional (2D) arbitrary shape electromagnetic transparent device is designed based on transformation optics. Laplace’s equation is adopted to construct the coordinate mapping between the original space and the transformed space. The design method is flexibly extended to three-dimensional (3D) case, which greatly enhances the applicability of transparent device. The protection of a horn antenna is taken as an example to show the effectiveness of the transparent device. Since the performance of the transparent device is independent on the inner antenna, it can be designed separately. Full-wave simulations are made to validate the results

3-Mesityl-2-oxo-1-oxaspiro­[4.4]non-3-en-4-yl benzoate

In the title compound, C24H24O4, a derivative of the potent insecticide and miticide spiro­mesifen, one cyclo­pentane C atom is disordered over two positions with occupancies of 0.574 (12) and 0.426 (12), resulting in respective envelope and twisted conformations for the cyclo­pentane ring. The atom at the flap position is 0.620 (5) Å out of the mean plane formed by the other four atoms of the envelope form. The furan ring makes dihedral angles of 68.26 (3) and 69.38 (2)°, respectively, with the 2,4,6-trimethyl­phenyl and benzene rings. The dihedral angle between the two benzene rings is 62.27 (3)°

Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

The mammalian target of rapamycin (mTOR) is known to regulate cell proliferation and growth by controlling protein translation. Recently, it has been shown that mTOR signaling pathway is involved in long-term synaptic plasticity. However, the role of mTOR under different pain conditions is less clear. In this study, the spatiotemporal activation of mTOR that contributes to pain-related behaviors was investigated using a novel animal inflammatory pain model induced by BmK I, a sodium channel-specific modulator purified from scorpion venom. In this study, intraplantar injections of BmK I were found to induce the activation of mTOR, p70 ribosomal S6 protein kinase (p70 S6K) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) in rat L5-L6 spinal neurons. In the spinal cord, mTOR, p70 S6K and 4E-BP1 were observed to be activated in the ipsilateral and contralateral regions, peaking at 1-2 h and recovery at 24 h post-intraplantar (i.pl.) BmK I administration. In addition, intrathecal (i.t.) injection of rapamycin - a specific inhibitor of mTOR - was observed to result in the reduction of spontaneous pain responses and the attenuation of unilateral thermal and bilateral mechanical hypersensitivity elicited by BmK I. Thus, these results indicate that the mTOR signaling pathway is mobilized in the induction and maintenance of pain-activated hypersensitivity