7 research outputs found
COMET 17P/HOLMES: CONTRAST IN ACTIVITY BETWEEN BEFORE AND AFTER THE 2007 OUTBURST
International audienc
Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease.
Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies.
Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed.
Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model.
Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms.
Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies.111414Nsciescopu