Dynamic physical activity recommendation on personalised mobile health information service: A deep reinforcement learning approach

Mobile health (mHealth) information service makes healthcare management easier for users, who want to increase physical activity and improve health. However, the differences in activity preference among the individual, adherence problems, and uncertainty of future health outcomes may reduce the effect of the mHealth information service. The current health service system usually provides recommendations based on fixed exercise plans that do not satisfy the user specific needs. This paper seeks an efficient way to make physical activity recommendation decisions on physical activity promotion in personalised mHealth information service by establishing data-driven model. In this study, we propose a real-time interaction model to select the optimal exercise plan for the individual considering the time-varying characteristics in maximising the long-term health utility of the user. We construct a framework for mHealth information service system comprising a personalised AI module, which is based on the scientific knowledge about physical activity to evaluate the individual exercise performance, which may increase the awareness of the mHealth artificial intelligence system. The proposed deep reinforcement learning (DRL) methodology combining two classes of approaches to improve the learning capability for the mHealth information service system. A deep learning method is introduced to construct the hybrid neural network combing long-short term memory (LSTM) network and deep neural network (DNN) techniques to infer the individual exercise behavior from the time series data. A reinforcement learning method is applied based on the asynchronous advantage actor-critic algorithm to find the optimal policy through exploration and exploitation

Predicting the Next Best View for 3D Mesh Refinement

3D reconstruction is a core task in many applications such as robot navigation or sites inspections. Finding the best poses to capture part of the scene is one of the most challenging topic that goes under the name of Next Best View. Recently, many volumetric methods have been proposed; they choose the Next Best View by reasoning over a 3D voxelized space and by finding which pose minimizes the uncertainty decoded into the voxels. Such methods are effective, but they do not scale well since the underlaying representation requires a huge amount of memory. In this paper we propose a novel mesh-based approach which focuses on the worst reconstructed region of the environment mesh. We define a photo-consistent index to evaluate the 3D mesh accuracy, and an energy function over the worst regions of the mesh which takes into account the mutual parallax with respect to the previous cameras, the angle of incidence of the viewing ray to the surface and the visibility of the region. We test our approach over a well known dataset and achieve state-of-the-art results.Comment: 13 pages, 5 figures, to be published in IAS-1

Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium-dependent protein kinase 3.

Toxoplasma gondii parasites rapidly exit their host cell when exposed to calcium ionophores. Calcium-dependent protein kinase 3 (TgCDPK3) was previously identified as a key mediator in this process, as TgCDPK3 knockout (∆cdpk3) parasites fail to egress in a timely manner. Phosphoproteomic analysis comparing WT with ∆cdpk3 parasites revealed changes in the TgCDPK3-dependent phosphoproteome that included proteins important for regulating motility, but also metabolic enzymes, indicating that TgCDPK3 controls processes beyond egress. Here we have investigated a predicted direct target of TgCDPK3, ApiAT5-3, a putative transporter of the major facilitator superfamily, and show that it is rapidly phosphorylated at serine 56 after induction of calcium signalling. Conditional knockout of apiAT5-3 results in transcriptional upregulation of most ribosomal subunits, but no alternative transporters, and subsequent parasite death. Mutating the S56 to a non-phosphorylatable alanine leads to a fitness cost, suggesting that phosphorylation of this residue is beneficial, albeit not essential, for tyrosine import. Using a combination of metabolomics and heterologous expression, we confirmed a primary role in tyrosine import for ApiAT5-3. However, no significant differences in tyrosine import could be detected in phosphorylation site mutants showing that if tyrosine transport is affected by S56 phosphorylation, its regulatory role is subtle

Circuit Design of Multimodal Attention Memristive Network for Affective Video Content Analysis

Affective video content analysis aims at automatically identifying human emotion triggered by video, which plays an important role in mental health monitoring. This paper proposes a multimodal attention memristive network for affective video content analysis, which offers an energy-efficient approach with low time consumption and high classification accuracy. To illustrate the complexity of the proposed multimodal attention memristive network, two core modules are proposed. Firstly, unimodal feature representation module with cascaded configuration is designed to capture unique characteristics from multimodal signals. Then, multimodal local-global fusion module is proposed to stimulate the process of multimodal information sensing and processing in human brain. Furthermore, the proposed system is validated by applying it to affective content analysis. The experimental results demonstrate that the multimodal attention memristive network outperforms the existing state-of-the-art methods with high classification accuracy and low time consumption.10.13039/501100001809-National Natural Science Foundation of China (Grant Number: 62001149

Heterogeneous Genomic Divergence Landscape in Two Commercially Important European Scallop Species

Two commercially important scallop species of the genus Pecten are found in Europe: the north Atlantic Pecten maximus and the Mediterranean Pecten jacobaeus whose distributions abut at the Almeria–Orán front. Whilst previous studies have quantified genetic divergence between these species, the pattern of differentiation along the Pecten genome is unknown. Here, we mapped RADseq data from 235 P. maximus and 27 P. jacobaeus to a chromosome-level reference genome, finding a heterogeneous landscape of genomic differentiation. Highly divergent genomic regions were identified across 14 chromosomes, while the remaining five showed little differentiation. Demographic and comparative genomics analyses suggest that this pattern resulted from an initial extended period of isolation, which promoted divergence, followed by differential gene flow across the genome during secondary contact. Single nucleotide polymorphisms present within highly divergent genomic regions were located in areas of low recombination and contrasting patterns of LD decay were found between the two species, hinting at the presence of chromosomal inversions in P. jacobaeus. Functional annotations revealed that highly differentiated regions were enriched for immune-related processes and mRNA modification. While future work is necessary to characterize structural differences, this study provides new insights into the speciation genomics of P. maximus and P. jacobaeus

A Brain-Inspired In-Memory Computing System for Neuronal Communication via Memristive Circuits

This work was supported in part by the National Natural Science Foundation of China under Grant U1909201 and Grant 62001149, and the Natural Science Foundation of Zhejiang Province under Grant LQ21F010009

Design and Implementation of a Flexible Neuromorphic Computing System for Affective Communication via Memristive Circuits

National Natural Science Foundation of China under Grant 62001149, Natural Science Foundation of Zhejiang Province under Grant LQ21F010009 and Fundamental Research funds for the provincial Universities of Zhejiang under Grant GK229909299001-06

External sources of clean technology: evidence from the clean development mechanism

New technology is fundamental to sustainable development. However, inventors from industrialized countries often refuse technology transfer because they worry about reverse-engineering. When can clean technology transfer succeed? We develop a formal model of the political economy of North–South technology transfer. According to the model, technology transfer is possible if (1) the technology in focus has limited global commercial potential or (2) the host developing country does not have the capacity to absorb new technologies for commercial use. If both conditions fail, inventors from industrialized countries worry about the adverse competitiveness effects of reverse-engineering, so technology transfer fails. Data analysis of technology transfer in 4,894 projects implemented under the Kyoto Protocol’s Clean Development Mechanism during the 2004–2010 period provides evidence in support of the model

An observational study of patient characteristics associated with the mode of admission to acute stroke services in North East, England

Objective Effective provision of urgent stroke care relies upon admission to hospital by emergency ambulance and may involve pre-hospital redirection. The proportion and characteristics of patients who do not arrive by emergency ambulance and their impact on service efficiency is unclear. To assist in the planning of regional stroke services we examined the volume, characteristics and prognosis of patients according to the mode of presentation to local services. Study design and setting A prospective regional database of consecutive acute stroke admissions was conducted in North East, England between 01/09/10-30/09/11. Case ascertainment and transport mode were checked against hospital coding and ambulance dispatch databases. Results Twelve acute stroke units contributed data for a mean of 10.7 months. 2792/3131 (89%) patients received a diagnosis of stroke within 24 hours of admission: 2002 arrivals by emergency ambulance; 538 by private transport or non-emergency ambulance; 252 unknown mode. Emergency ambulance patients were older (76 vs 69 years), more likely to be from institutional care (10% vs 1%) and experiencing total anterior circulation symptoms (27% vs 6%). Thrombolysis treatment was commoner following emergency admission (11% vs 4%). However patients attending without emergency ambulance had lower inpatient mortality (2% vs 18%), a lower rate of institutionalisation (1% vs 6%) and less need for daily carers (7% vs 16%). 149/155 (96%) of highly dependent patients were admitted by emergency ambulance, but none received thrombolysis. Conclusion Presentations of new stroke without emergency ambulance involvement were not unusual but were associated with a better outcome due to younger age, milder neurological impairment and lower levels of pre-stroke dependency. Most patients with a high level of pre-stroke dependency arrived by emergency ambulance but did not receive thrombolysis. It is important to be aware of easily identifiable demographic groups that differ in their potential to gain from different service configurations