Constraints on nuclear matter parameters of an Effective Chiral Model

Within an effective non-linear chiral model, we evaluate nuclear matter parameters exploiting the uncertainties in the nuclear saturation properties. The model is sternly constrained with minimal free parameters, which display the interlink between nuclear incompressibility ($K$), the nucleon effective mass ($m^{\star}$), the pion decay constant ($f_{\pi}$) and the $\sigma-$meson mass ($m_{\sigma}$). The best fit among the various parameter set is then extracted and employed to study the resulting Equation of state (EOS). Further, we also discuss the consequences of imposing constraints on nuclear EOS from Heavy-Ion collision and other phenomenological model predictions.Comment: 10 pages, 8 figure

On attributes of a Rotating Neutron star with a Hyperon core

We study the effect of rotation on global properties of neutron star with a hyperon core in an effective chiral model with varying nucleon effective mass within a mean field approach. The resulting gross properties of the rotating compact star sequences are then compared and analyzed with other theoretical predictions and observations from neutron stars. The maximum mass of the compact star predicted by the model lies in the range $(1.4-2.4) ~M_{\odot}$ at Kepler frequency $\Omega_K$, which is consistant with recent observation of high mass stars thereby reflecting the sensitivity of the underlying nucleon effective mass in the dense matter EoS. We also discuss the implications of the experimental constraints from the flow data from heavy-ion collisions on the global properties of the rotating neutron stars.Comment: 11 Pages, 10 Figures and 2 Table

Bulk viscosity in hyperonic star and r-mode instability

We consider a rotating neutron star with the presence of hyperons in its core, using an equation of state in an effective chiral model within the relativistic mean field approximation. We calculate the hyperonic bulk viscosity coefficient due to nonleptonic weak interactions. By estimating the damping timescales of the dissipative processes, we investigate its role in the suppression of gravitationally driven instabilities in the $r$-mode. We observe that $r$-mode instability remains very much significant for hyperon core temperature of around $10^8$K, resulting in a comparatively larger instability window. We find that such instability can reduce the angular velocity of the rapidly rotating star considerably upto $\sim0.04 \Omega_K$, with $\Omega_K$ as the Keplerian angular velocity.Comment: 10 pages including 7 figure

Controlling laser spectra in a phaseonium photonic crystal using maser

We study the control of quantum resonances in photonic crystals with electromagnetically induced transparency driven by microwave field. In addition to the control laser, the intensity and phase of the maser can alter the transmission and reflection spectra in interesting ways, producing hyperfine resonances through the combined effects of multiple scattering in the superstructure.Comment: 7 pages, 4 figure

Effect of the σ\sigma-cut potential on the properties of neutron stars with or without a hyperonic core

Motivated by the recent observation of high-mass pulsars ($M \simeq 2 M_{\odot}$), we employ the $\sigma$-cut potential on the equation of state (EOS) of high-density matter and the properties of neutron stars within the relativistic mean-field (RMF) model using TM1$^{*}$ parameter set. The $\sigma$-cut potential is known to reduce the contributions of the $\sigma$ field, resulting in a stiffer EOS at high densities and hence leading to larger neutron star masses without affecting the properties of nuclear matter at normal saturation density. We also analyzed the effect of the same on pure neutron matter and also on the neutron star matter with and without hyperonic core and compared it with the available theoretical, experimental, and observational data. The corresponding tidal deformability ($\Lambda_{1.4}$) is also calculated. With the choice of meson-hyperon coupling fixed to hypernuclear potentials, we obtain $\approx 10~\%$ increase in mass by employing the $\sigma$-cut potential for $f_{s} = 0.6$. Our results are in good agreement with various experimental constraints and observational data, particularly with the GW170817 data.Comment: 7 Pages, 6 Figures and 1 Table (Accepted in Phys. Rev. C

Enrolment in clinical research at UCLH and geographically distributed indices of deprivation [version 1; peer review: awaiting peer review]

Healthcare should be judged by its equity as well as its quality. Both aspects depend not only on the characteristics of service delivery but also on the research and innovation that ultimately shape them. Conducting a fully-inclusive evaluation of the relationship between enrolment in primary research studies at University College London Hospitals NHS Trust and indices of deprivation, here we demonstrate a quantitative approach to evaluating equity in healthcare research and innovation. We surveyed the geographical locations, aggregated into Lower Layer Super Output Areas (LSOAs), of all England-resident UCLH patients registered as enrolled in primary clinical research studies. We compared the distributions of ten established indices of deprivation across enrolled and non-enrolled areas within Greater London and within a distance-matched subset across England. Bayesian Poisson regression models were used to examine the relation between deprivation and the volume of enrolment standardized by population density and local disease prevalence. A total of 54593 enrolments covered 4401 LSOAs in Greater London and 10150 in England, revealing wide geographical reach. The distributions of deprivation indices were similar between enrolled and non-enrolled areas, exhibiting median differences from 0.26% to 8.73%. Across Greater London, enrolled areas were significantly more deprived on most indices, including the Index of Multiple Deprivation; across England, a more balanced relationship to deprivation emerged. Regression analyses of enrolment volumes yielded weak biases, in favour of greater deprivation for most indices, with little modulation by local disease prevalence. Primary clinical research at UCLH has wide geographical reach. Areas with enrolled patients show similar distributions of established indices of deprivation to those without, both within Greater London, and across distance-matched areas of England. We illustrate a robust approach to quantifying an important aspect of equity in clinical research and provide a flexible set of tools for replicating it across other institutions

Role of 2-5A-Dependent RNase-L in Senescence and Longevity

Senescence is a permanent growth arrest that restricts the lifespan of primary cells in culture, and represents an in vitro model for aging. Senescence functions as a tumor suppressor mechanism that can be induced independent of replicative crisis by diverse stress stimuli. RNase-L mediates antiproliferative activities and functions as a tumor suppressor in prostate cancer, therefore, we examined a role for RNase-L in cellular senescence and aging. Ectopic expression of RNase-L induced a senescent morphology, a decrease in DNA synthesis, an increase in senescence-associated -galactosidase activity, and accelerated replicative senescence. In contrast, senescence was retarded in RNase-L-null fibroblasts compared with wild-type fibroblasts. Activation of endogenous RNase-L by 2-5A transfection induced distinct senescent and apoptotic responses in parental and Simian virus 40-transformed WI38 fibroblasts, respectively, demonstrating cell type specific differences in the antiproliferative response to RNase-L activation. Replicative senescence is a model for in vivo aging; therefore, genetic disruption of senescence effectors may impact lifespan. RNase-L-/- mice survived 31.7% (P\u3c0.0001) longer than strain-matched RNase-L+/+ mice providing evidence for a physiological role for RNase-L in aging. These findings identify a novel role for RNase-L in senescence that may contribute to its tumor suppressive function and to the enhanced longevity of RNase-L-/- mice

Role of 2-5A-Dependent RNase-L in Senescence and Longevity

Senescence is a permanent growth arrest that restricts the lifespan of primary cells in culture, and represents an in vitro model for aging. Senescence functions as a tumor suppressor mechanism that can be induced independent of replicative crisis by diverse stress stimuli. RNase-L mediates antiproliferative activities and functions as a tumor suppressor in prostate cancer, therefore, we examined a role for RNase-L in cellular senescence and aging. Ectopic expression of RNase-L induced a senescent morphology, a decrease in DNA synthesis, an increase in senescence-associated -galactosidase activity, and accelerated replicative senescence. In contrast, senescence was retarded in RNase-L-null fibroblasts compared with wild-type fibroblasts. Activation of endogenous RNase-L by 2-5A transfection induced distinct senescent and apoptotic responses in parental and Simian virus 40-transformed WI38 fibroblasts, respectively, demonstrating cell type specific differences in the antiproliferative response to RNase-L activation. Replicative senescence is a model for in vivo aging; therefore, genetic disruption of senescence effectors may impact lifespan. RNase-L-/- mice survived 31.7% (P\u3c0.0001) longer than strain-matched RNase-L+/+ mice providing evidence for a physiological role for RNase-L in aging. These findings identify a novel role for RNase-L in senescence that may contribute to its tumor suppressive function and to the enhanced longevity of RNase-L-/- mice

Impact of farmer producer organization on organic chilli production in Telangana, India

Input intensive modern agriculture is adversely affecting human health and environment. Farmers of Telangana state have taken up organic chilli production with the assistance of FPOs. Primary data was collected from 120 farmers comprising 60 members and 60 non-members of FPO from two districts of Telangana through semi-structured interviews. The study found that the shift to organic chilli cultivation led to decrease in input use by 9.06% and yield by 23.4%. However, the gross return from organic chilli farming was 13.85% higher over that realised by non-members due to the efforts of FPOs. DEA analysis revealed that a higher proportion of member farmers (48%) had technical efficiency of more than 60% as compared to non-members (18%). FPOs were instrumental in reduction of transaction cost and number of intermediaries leading to the realization of a higher proportion of producer’s share in consumer’s rupee (65%). Discriminant function analysis revealed that the FPO promoting institutions (44%), ease of doing business (16%) and infrastructure facilities like storage, irrigation, electricity and credit have high influence on performance of the states with respect to FPOs