Does balance training improve quality of life in adults with osteoporosis?

Objective: The objective of this selective EBM review is to determine whether or not balance training improves quality of life in adults with osteoporosis. Study Design: Review of two randomized controlled trials and one case series. Data Sources: All three studies were found using Pubmed. They were originally published in peer-reviewed journals between 2010 and 2017. Outcomes Measured: The outcome measured was quality of life. The randomized controlled trials measured quality of life using frequency of falling, and the case series measured it using the Activities-specific Balance Confidence scale (ABC-6). Results: Mikó et al. was a RCT that showed balance training could reduce falls in a statistically significant number of people (p\u3c0.05). The other RCT, Madureira et al., also found that balance training reduced frequency of falling in a statistically significant percentage of people (p=0.025). Konak et al. was a case series which revealed that balance training increased balance self-confidence when performing the daily activities measured via the ABC-6 scale by a statistically significant amount (p\u3c0.001). Conclusions: All three of the studies examined in this EBM review suggest that adults with osteoporosis who undergo a balance training program can improve their quality of life, as balance training can prevent or reduce falls in addition to increasing self-confidence in performing daily activities. Future studies should include more men and younger patients at risk for fragility fractures so that the results can be more generalizable. Additionally, future studies should investigate the optimal length of time that a balance training regimen needs to last in order to have the most benefit, as well as how long the benefit from the training lasts after the program stops

A lattice model for condensation in Levin-Wen systems

Levin-Wen string-net models provide a construction of (2+1)D topologically ordered phases of matter with anyonic localized excitations described by the {Drinfeld} center of a unitary fusion category. Anyon condensation is a mechanism for phase transitions between (2+1)D topologically ordered phases. We construct an extension of Levin-Wen models in which tuning a parameter implements anyon condensation. We also describe the classification of anyons in Levin-Wen models via representation theory of the tube algebra, and use a variant of the tube algebra to classify low-energy localized excitations in the condensed phase.Comment: 45 pages; numerous figure

Gas-Modified Electrospinning with a Portable Device

Project Objective The objective of this work was to construct a miniaturized, portable electrospinning (ES) device for deposition on surfaces regardless of charge. We hope this device can be used by doctors in rural areas to deliver drug delivery bandages. Mathematical modeling was used to improve predictability of the completed portable ES device

Deposition of Drug-delivering Bandages via a Combined Electrostatic and Air-Driven Electrospinning Device

Electrospinning (ES) is an affordable manufacturing process to produce nanoscale, polymer fibers. During ES, a high voltage differential is required to draw out polymer fibers from a polymer solution at a charged spinneret. Fibers produced are then deposited onto an oppositely charged electrode. ES typically requires large, immovable equipment and conductive surfaces for deposition of fibers. Portability and on-demand ES of fiber mats onto non-conductive surfaces would enable use in re- mote locations with limited access to medicine

Ratification of the Base of the ICS Geological Time Scale: The Global Standard Stratigraphic Age (GSSA) for the Hadean Lower Boundary

The base of the ICS (International Commission on Stratigraphy) Geological Time Scale was ratified in 2022 by defining a new Global Stratigraphic Standard Age (GSSA) for the lower boundary of the Hadean Eon (formerly 4000-3600 Ma); the age of the Solar System based on the oldest solids, calcium-aluminium inclusions (CAIs), generated in the protoplanetary disk. The formal GSSA for the Hadean base is the oldest reliable, weighted mean U-corrected Pb-Pb age of 4567.30 ± 0.16 Ma obtained for CAIs in primitive meteorites Allende and Efremovka. This age is supported by the 4568-4567 Ma U-corrected Pb-Pb ages of chondrules in Northwest African meteorites. The boundary sets an upper lifetime for the protoplanetary disk and timing of planet formation. The Hadean Eon encloses the accretion and differentiation of the Earth and other planets, the Moon-forming Giant Impact, the beginning of the suggested Late Heavy Bombardment, and the formation of the Earth\u27s protocrust. Due to the Moon-forming Giant Impact that occurred after the differentiation of the proto-Earth and the fact that Earth\u27s first crust has been destroyed, the age of the planet Earth itself remains an open question. However, many pieces of astronomical, chemical, physical, and chronological evidence point to the very fast formation of the Solar System and rapid accretion and differentiation of the proto-Earth in only a few million years. Compared to the half-billion-year duration of the Hadean, it is reasonable to set the age of the Earth at the beginning of the formation of the Solar System. This communication explains and justifies the selection of the GSSA for the Hadean base

Ratification of the base of the ICS Geological Time Scale : the Global Standard Stratigraphic Age (GSSA) for the Hadean lower boundary

Peer reviewe

Ratification of the base of the ICS Geological Time Scale: the Global Standard Stratigraphic Age (GSSA) for the Hadean lower boundary

The base of the ICS (International Commission on Stratigraphy) Geological Time Scale was ratified in 2022 by defining a new Global Stratigraphic Standard Age (GSSA) for the lower boundary of the Hadean Eon (formerly 4000–3600 Ma); the age of the Solar System based on the oldest solids, calcium-aluminium inclusions (CAIs), generated in the protoplanetary disk. The formal GSSA for the Hadean base is the oldest reliable, weighted mean Ucorrected Pb–Pb age of 4567.30 ± 0.16 Ma obtained for CAIs in primitive meteorites Allende and Efremovka. This age is supported by the 4568–4567 Ma U-corrected Pb–Pb ages of chondrules in Northwest African meteorites. The boundary sets an upper lifetime for the protoplanetary disk and timing of planet formation. The Hadean Eon encloses the accretion and differentiation of the Earth and other planets, the Moon-forming Giant Impact, the beginning of the suggested Late Heavy Bombardment, and the formation of the Earth’s protocrust. Due to the Moon-forming Giant Impact that occurred after the differentiation of the proto-Earth and the fact that Earth’s first crust has been destroyed, the age of the planet Earth itself remains an open question. However, many pieces of astronomical, chemical, physical, and chronological evidence point to the very fast formation of the Solar System and rapid accretion and differentiation of the proto-Earth in only a few million years. Compared to the half-billion-year duration of the Hadean, it is reasonable to set the age of the Earth at the beginning of the formation of the Solar System. This communication explains and justifies the selection of the GSSA for the Hadean base

The Galactic Center with Roman

We advocate for a Galactic center (GC) field to be added to the Galactic Bulge Time Domain Survey (GBTDS). The new field would yield high-cadence photometric and astrometric measurements of an unprecedented ${\sim}$3.3 million stars toward the GC. This would enable a wide range of science cases, such as finding star-compact object binaries that may ultimately merge as LISA-detectable gravitational wave sources, constraining the mass function of stars and compact objects in different environments, detecting populations of microlensing and transiting exoplanets, studying stellar flares and variability in young and old stars, and monitoring accretion onto the central supermassive black hole. In addition, high-precision proper motions and parallaxes would open a new window into the large-scale dynamics of stellar populations at the GC, yielding insights into the formation and evolution of galactic nuclei and their co-evolution with the growth of the supermassive black hole. We discuss the possible trade-offs between the notional GBTDS and the addition of a GC field with either an optimal or minimal cadence. Ultimately, the addition of a GC field to the GBTDS would dramatically increase the science return of Roman and provide a legacy dataset to study the mid-plane and innermost regions of our Galaxy.Comment: 19 pages, 3 figures. Submitted to the NASA Roman Core Community Surveys White Paper Cal

Roman CCS White Paper: Characterizing the Galactic population of isolated black holes

Although there are estimated to be 100 million isolated black holes (BHs) in the Milky Way, only one has been found so far, resulting in significant uncertainty about their properties. The Galactic Bulge Time Domain Survey provides the only opportunity in the coming decades to grow this catalog by order(s) of magnitude. This can be achieved if 1) Roman's astrometric potential is fully realized in the observation strategy and software pipelines, 2) Roman's observational gaps of the Bulge are minimized, and 3) observations with ground-based facilities are taken of the Bulge to fill in gaps during non-Bulge seasons. A large sample of isolated BHs will enable a broad range of astrophysical questions to be answered, such as massive stellar evolution, origin of gravitational wave sources, supernova physics, and the growth of supermassive BHs, maximizing Roman's scientific return.Comment: 20 pages. Submitted in response to Nancy Grace Roman Space Telescope white paper call: https://roman.gsfc.nasa.gov/science/ccs_white_papers.htm

Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We observed in alcohol-dependent patients increased serum activity of neutral sphingomyelinase. A genetic association analysis in 456,693 volunteers found associations of haplotypes of SMPD3 coding for NSM-2 (NSM) with alcohol consumption, but also with affective state, and bone mineralisation. Functional analysis in mice showed that NSM controls alcohol consumption, affective behaviour, and their interaction by regulating hippocampal volume, cortical connectivity, and monoaminergic responses. Furthermore, NSM controlled bone–brain communication by enhancing osteocalcin signalling, which can independently supress alcohol consumption and reduce depressive behaviour. Altogether, we identified a single gene source for multiple pathways originating in the brain and bone, which interlink disorders of a mental–physical co-morbidity trias of alcohol abuse—depression/anxiety—bone disorder. Targeting NSM and osteocalcin signalling may, thus, provide a new systems approach in the treatment of a mental–physical co-morbidity trias