Umstrittene Aufklärung – die theologischen Auseinandersetzungen um die Altonaer Bibel

Der vierte Teil der Hamburgischen Kirchengeschichte in Aufsätzen ist dem 19. Jahrhundert gewidmet. Angesichts der folgenreichen Auf- und Umbrüche, der vielen wichtigen Themen und prägenden Gestalten bilden die hier wieder abgedruckten oder neu verfassten Texte nur einige der für die Kirchengeschichte Hamburgs in dieser bewegten Epoche einschlägigen Ereignisse und Entwicklungen ab. Ungeachtet aller Ergänzungsmöglichkeiten bietet dieser Band zahlreiche neue wie erhellende Einblicke in den spannenden Urbanisierungsprozess einer Großstadt und ihrer Kirchen auf ihrem von Katastrophen und Glücksfällen, von Reformeifer und Konservativismus gleichermaßen gezeichneten Weg in die Moderne.The fourth part of Hamburg\u27s church history in essays is dedicated to the 19th century. Considering the momentous upheavals and upheavals and the variety of important themes and formative figures, the texts reprinted or newly written here reflect only some of the events and developments relevant to Hamburg\u27s church history in this eventful epoch. Irrespective of all possible additions, this volume offers numerous new and enlightening insights into the exciting urbanization process of a city and its churches on their path to modernity, marked by catastrophes and fortunes, reformist zeal and conservatism

Insights into German polar research during POLARSTUNDE

Polar research is an interdisciplinary and multi-faceted field of research ranging from history to geology and geophysics to social sciences and education. Thus, several different universities and institutions within Germany participate in polar research. The seminar series POLARSTUNDE, organized by the German Society for Polar Research (Deutsche Gesellschaft für Polarforschung) and the German National Committee of the Association of Polar Early Career Scientists (APECS Germany) regularly features different topics of German polar research. Although initially a "pandemic solution", the seminar series has established itself as a valuable and highly successful part of the German polar research landscape. The seminar series was held in German and was aimed at both scientists and the general public. This article addresses the first season of POLARSTUNDE and provides (1) comprehensive summaries of the talks and (2) insight into the planning and execution from an organizational point of view

Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial.

peer reviewed[en] OBJECTIVES: Older adults with subjective cognitive decline (SCD) recruited from memory clinics have an increased risk of developing dementia and regularly experience reduced psychological well-being related to memory concerns and fear of dementia. Research on improving well-being in SCD is limited and lacks non-pharmacological approaches. We investigated whether mindfulness-based and health education interventions can enhance well-being in SCD. METHODS: The SCD-Well trial (ClinicalTrials.gov: NCT03005652) randomised 147 older adults with SCD to an 8-week caring mindfulness-based approach for seniors (CMBAS) or an active comparator (health self-management programme [HSMP]). Well-being was assessed at baseline, post-intervention, and 6-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation's Quality of Life (QoL) Assessment psychological subscale, and composites capturing meditation-based well-being dimensions of awareness, connection, and insight. Mixed effects models were used to assess between- and within-group differences in change. RESULTS: CMBAS was superior to HSMP on changes in connection at post-intervention. Within both groups, PWBS total scores, psychological QoL, and composite scores did not increase. Exploratory analyses indicated increases in PWBS autonomy at post-intervention in both groups. CONCLUSION: Two non-pharmacological interventions were associated with only limited effects on psychological well-being in SCD. Longer intervention studies with waitlist/retest control groups are needed to assess if our findings reflect intervention brevity and/or minimal base rate changes in well-being

Hamburgische Kirchengeschichte in Aufsätzen ‒ bisher erschienene Bände

Der vierte Teil der Hamburgischen Kirchengeschichte in Aufsätzen ist dem 19. Jahrhundert gewidmet. Angesichts der folgenreichen Auf- und Umbrüche, der vielen wichtigen Themen und prägenden Gestalten bilden die hier wieder abgedruckten oder neu verfassten Texte nur einige der für die Kirchengeschichte Hamburgs in dieser bewegten Epoche einschlägigen Ereignisse und Entwicklungen ab. Ungeachtet aller Ergänzungsmöglichkeiten bietet dieser Band zahlreiche neue wie erhellende Einblicke in den spannenden Urbanisierungsprozess einer Großstadt und ihrer Kirchen auf ihrem von Katastrophen und Glücksfällen, von Reformeifer und Konservativismus gleichermaßen gezeichneten Weg in die Moderne.The fourth part of Hamburg\u27s church history in essays is dedicated to the 19th century. Considering the momentous upheavals and upheavals and the variety of important themes and formative figures, the texts reprinted or newly written here reflect only some of the events and developments relevant to Hamburg\u27s church history in this eventful epoch. Irrespective of all possible additions, this volume offers numerous new and enlightening insights into the exciting urbanization process of a city and its churches on their path to modernity, marked by catastrophes and fortunes, reformist zeal and conservatism

Effects of a mindfulness-based versus a health self-management intervention on objective cognitive performance in older adults with subjective cognitive decline (SCD): a secondary analysis of the SCD-Well randomized controlled trial.

peer reviewedBACKGROUND: Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk of objective cognitive decline and incident dementia. Non-pharmacological interventions (including mindfulness-based and health self-management approaches) are a potential strategy to maintain or improve cognition in SCD, which may ultimately reduce dementia risk. METHODS: This study utilized data from the SCD-Well randomized controlled trial. One hundred forty-seven older adults with SCD (MAge = 72.7 years; 64% female) were recruited from memory clinics in four European countries and randomized to one of two group-based, 8-week interventions: a Caring Mindfulness-based Approach for Seniors (CMBAS) or a health self-management program (HSMP). Participants were assessed at baseline, post-intervention (week 8), and at 6-month follow-up (week 24) using a range of cognitive tests. From these tests, three composites were derived-an "abridged" Preclinical Alzheimer's Cognitive Composite 5 (PACC5Abridged), an attention composite, and an executive function composite. Both per-protocol and intention-to-treat analyses were performed. Linear mixed models evaluated the change in outcomes between and within arms and adjusted for covariates and cognitive retest effects. Sensitivity models repeated the per-protocol analyses for participants who attended ≥ 4 intervention sessions. RESULTS: Across all cognitive composites, there were no significant time-by-trial arm interactions and no measurable cognitive retest effects; sensitivity analyses supported these results. Improvements, however, were observed within both trial arms on the PACC5Abridged from baseline to follow-up (Δ [95% confidence interval]: CMBAS = 0.34 [0.19, 0.48]; HSMP = 0.30 [0.15, 0.44]). There was weaker evidence of an improvement in attention but no effects on executive function. CONCLUSIONS: Two non-pharmacological interventions conferred small, non-differing improvements to a global cognitive composite sensitive to amyloid-beta-related decline. There was weaker evidence of an effect on attention, and no evidence of an effect on executive function. Importantly, observed improvements were maintained beyond the end of the interventions. Improving cognition is an important step toward dementia prevention, and future research is needed to delineate the mechanisms of action of these interventions and to utilize clinical endpoints (i.e., progression to mild cognitive impairment or dementia). TRIAL REGISTRATION: ClinicalTrials.gov, NCT03005652

H2O2 selectively damages the binuclear iron-sulfur cluster N1b of respiratory complex I

Abstract NADH:ubiquinone oxidoreductase, respiratory complex I, plays a major role in cellular energy metabolism by coupling electron transfer with proton translocation. Electron transfer is catalyzed by a flavin mononucleotide and a series of iron-sulfur (Fe/S) clusters. As a by-product of the reaction, the reduced flavin generates reactive oxygen species (ROS). It was suggested that the ROS generated by the respiratory chain in general could damage the Fe/S clusters of the complex. Here, we show that the binuclear Fe/S cluster N1b is specifically damaged by H2O2, however, only at high concentrations. But under the same conditions, the activity of the complex is hardly affected, since N1b can be easily bypassed during electron transfer

Hepatitis A outbreak among MSM in Berlin due to low vaccination coverage: Epidemiology, management, and successful interventions

Objectives To describe the characteristics of a large hepatitis A virus (HAV) outbreak among men who have sex with men (MSM) in Berlin and to assess the impact of measures implemented. Methods Cases of laboratory-confirmed, symptomatic HAV infection notified in Berlin, Germany between August 2016 and February 2018 were analysed using routine and enhanced surveillance data including genotyping results. Several studies involving different groups of participants were conducted to further investigate the outbreak, including surveys on knowledge and practices of HAV vaccination among physicians and vaccination coverage and determinants of vaccination status among MSM. The measures implemented were categorized by target group in a Gantt chart. To assess their impact, health insurance data on HAV vaccination uptake were analysed, comparing Berlin and other federal states. Results During the outbreak period, a total of 222 cases were reported (of which 91 were sequence-confirmed), with a peak in case numbers in January 2017. Physicians were aware of the existing vaccination recommendations, but vaccination coverage among 756 MSM was low, with 32.7% being completely vaccinated and 17.3% being incompletely vaccinated before 2017. HAV vaccination before 2017 was associated with being born in Germany (odds ratio 2.36) and HIV-positive (odds ratio 1.80). HAV monovalent vaccination uptake increased by 164% from 2016 to 2017 among males in Berlin, compared to 7% in other federal states. Conclusions Multiple measures targeting the MSM community, physicians, and public health to increase HAV vaccination uptake were successfully implemented. To prevent future HAV outbreaks, we recommend monitoring vaccination coverage among MSM, promoting awareness of existing recommendations among physicians, and ensuring access for foreign-born and young MSM

Systems chemistry of aminoacyl phosphates: Spontaneous and selective peptide oligomerisation in water driven by phase changes

The pathways and mechanisms that allow spontaneous and selective peptide elongation in aqueous abiotic systems remain unclear. Herein we work to uncover those pathways by following the systems chemistry of aminoacyl phosphates, the synthetic counterpart of aminoacyl adenylates. Thus, oligomers up to dodecamers were synthesized in one flask and on the minute time scale, where consecutive additions activated autonomous phase changes. The resulting phases arose from the high polar and reactive nature of the aminoacyl phosphates, which can be dissolved in water in concentrations of up to 300 mM. Upon elongation, short oligomers are prevalent in solution, while in the aggregated phase, longer oligomers are selected based on their aggregation propensity. We furthermore demonstrated that the solution phases can be isolated and act as a new environment for continuous elongation, by adding various phosphates. These findings suggest that the systems chemistry of aminoacyl phosphates can activate a selection mechanism for peptide formation, by merging aqueous synthesis and self-assembly