Properties of some conformal field theories with M-theory duals

By studying classes of supersymmetric solutions of D=11 supergravity with AdS_5 factors, we determine some properties of the dual four-dimensional N=1 superconformal field theories. For some explicit solutions we calculate the central charges and also the conformal dimensions of certain chiral primary operators arising from wrapped membranes. For the most general class of solutions we show that there is a consistent Kaluza-Klein truncation to minimal D=5 gauged supergravity. This latter result allows us to study some aspects of the dual strongly coupled thermal plasma with a non-zero R-charge chemical potential and, in particular, we show that the ratio of the shear viscosity to the entropy density has the universal value of 1/4 pi.Comment: Consistent truncation extended to include fermions. Reference added. 28 page

Consistent supersymmetric Kaluza--Klein truncations with massive modes

We construct consistent Kaluza--Klein reductions of D=11 supergravity to four dimensions using an arbitrary seven-dimensional Sasaki--Einstein manifold. At the level of bosonic fields, we extend the known reduction, which leads to minimal N=2 gauged supergravity, to also include a multiplet of massive fields, containing the breathing mode of the Sasaki--Einstein space, and still consistent with N=2 supersymmetry. In the context of flux compactifications, the Sasaki--Einstein reductions are generalizations of type IIA SU(3)-structure reductions which include both metric and form-field flux and lead to a massive universal tensor multiplet. We carry out a similar analysis for an arbitrary weak G_2 manifold leading to an N=1 supergravity with massive fields. The straightforward extension of our results to the case of the seven-sphere would imply that there is a four-dimensional Lagrangian with N=8 supersymmetry containing both massless and massive spin two fields. We use our results to construct solutions of M-theory with non-relativistic conformal symmetry.Comment: 33 pages. v2: Added section on skew-whiffed solutions and some brief comments on holographic superconductors. v3: typos corrected, version to be published in JHE

Geometries with Killing Spinors and Supersymmetric AdS Solutions

The seven and nine dimensional geometries associated with certain classes of supersymmetric $AdS_3$ and $AdS_2$ solutions of type IIB and D=11 supergravity, respectively, have many similarities with Sasaki-Einstein geometry. We further elucidate their properties and also generalise them to higher odd dimensions by introducing a new class of complex geometries in $2n+2$ dimensions, specified by a Riemannian metric, a scalar field and a closed three-form, which admit a particular kind of Killing spinor. In particular, for $n\ge 3$, we show that when the geometry in $2n+2$ dimensions is a cone we obtain a class of geometries in $2n+1$ dimensions, specified by a Riemannian metric, a scalar field and a closed two-form, which includes the seven and nine-dimensional geometries mentioned above when $n=3,4$, respectively. We also consider various ansatz for the geometries and construct infinite classes of explicit examples for all $n$.Comment: 28 page

Determining the virulence properties of Escherichia coli ST131 containing bacteriocin-encoding plasmids using short-and long-read sequencing and comparing them with those of other E. Coli lineages

T. Escherichia coli ST131 is a clinical challenge due to its multidrug resistant profile and successful global spread. They are often associated with complicated infections, particularly urinary tract infections (UTIs). Bacteriocins play an important role to outcompete other microorganisms present in the human gut. Here, we characterized bacteriocin-encoding plasmids found in ST131 isolates of patients suffering from a UTI using both short-and long-read sequencing. Colicins Ia, Ib and E1, and microcin V, were identified among plasmids that also contained resistance and virulence genes. To investigate if the potential transmission range of the colicin E1 plasmid is influenced by the presence of a resistance gene, we constructed a strain containing a plasmid which had both the colicin E1 and blaCMY-2 genes. No difference in transmission range was found between transformant and wild-type strains. However, a statistically significantly difference was found in adhesion and invasion ability. Bacteriocin-producing isolates from both ST131 and non-ST131 lineages were able to inhibit the growth of other E. coli isolates, including other ST131. In summary, plasmids harboring bacteriocins give additional advantages for highly virulent and resistant ST131 isolates, improving the ability of these isolates to compete with other microbiota for a niche and thereby increasing the risk of infection

Immunogenicity of toxins during Staphylococcus aureus infection

AB - BACKGROUND: Toxins are important Staphylococcus aureus virulence factors, but little is known about their immunogenicity during infection. Here, additional insight is generated. METHODS: Serum samples from 206 S. aureus-infected patients and 201 hospital-admitted control subjects were analyzed for immunoglobulin (Ig) G binding to 20 toxins, using flow-cytometry based technology. Antibody levels were associated with p

RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies

Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

A century of trends in adult human height

Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries