24 research outputs found
Absolute configuration of benzo(c)phenanthrene 5,6-oxide and other k-region derivatives.
No full textResolution and absolute configuration of k-region-trans-dihydrodiols from polycyclic aromatic hydrocarbons.
No full textSynthesis of the enantiomeric K-region arene 5,6-oxides derived from chrysene, 7,12-dimethylbenz[a]anthracene, and benzo[c]phenanthrene
No full textDifferential stereoselectivity of cytochrome P-450 b and P-450 c in the formation of naphtalene and anthracene 1,2-oxydes
No full textStereoselectivity of cytochrome P-450c in the formation of naphtalene and anthracene 1,2-oxides
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Polymorphisms in the Microsomal Epoxide Hydrolase Gene: Role in Lung Cancer Susceptibility and Prognosis
No full textAims and background. The aim of this study was to investigate the relationship between EPHXI exon 3 Tyr113His and exon 4 His139Arg polymorphisms, predicted microsomal epoxide hydrolase (mEH) activity, and lung cancer development. mEH is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens
Stereoselective metabolism of polycyclic aromatic hydrocarbons to carcinogenic metabolites
No full textChemical modification and inactivation of rat liver microsomal cytochrome P450c by 2-bromo-4'-nitroacetophenone.
No full textStereoselective formation of benzo(c)phenanthrene (+)-3S,4R and (+)5S,6R-oxide by cytochrome P450c in a highly purified and reconstituted system.
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