24 research outputs found
Absolute configuration of benzo(c)phenanthrene 5,6-oxide and other k-region derivatives.
Resolution and absolute configuration of k-region-trans-dihydrodiols from polycyclic aromatic hydrocarbons.
Synthesis of the enantiomeric K-region arene 5,6-oxides derived from chrysene, 7,12-dimethylbenz[a]anthracene, and benzo[c]phenanthrene
Differential stereoselectivity of cytochrome P-450 b and P-450 c in the formation of naphtalene and anthracene 1,2-oxydes
Stereoselectivity of cytochrome P-450c in the formation of naphtalene and anthracene 1,2-oxides
Polymorphisms in the Microsomal Epoxide Hydrolase Gene: Role in Lung Cancer Susceptibility and Prognosis
Aims and background. The aim of this study was to investigate the relationship between EPHXI exon 3 Tyr113His and exon 4 His139Arg polymorphisms, predicted microsomal epoxide hydrolase (mEH) activity, and lung cancer development. mEH is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens