3,026 research outputs found
Not All Job Stressors Are Harmful: The Role of Employees’ Psychological Capital
Human resources are an important asset for the hospitality industry; however, long working hours, low pay, and demanding customers are known to increase hospitality employees’ job stress. Work stress contributes to a high turnover rate in the hospitality industry; thus, it is critical for hospitality practitioners to understand work-related stressors and aid employees in coping with their stress. Challenge stressors can be viewed as beneficial to employees, while hindrance stressors tend to bring little benefit to employees. Through a survey of 232 hotel employees, we examined the role of psychological capital in the association between job stressors and employee burnout and engagement. We found that employees who are high in psychological capital embrace challenge stressors as opportunities rather than simple, stressful situations. This positive mindset towards challenge stressors helps employees to concentrate on their work. At the same time, psychological capital reduces the feeling of job stress. People high in psychological capital experience much slower growth in stress when facing various types of job demands. In other words, they are more resilient to work stress. Management should consider offering official companywide training with appropriate activities in order to bolster their employees’ personal resource, “psychological capital”, and monitor the effectiveness of their training on a regular basis
Do All Angry Customers Complain?
Customer complaints can shed light on organizations’ key performance practices, providing useful information for organizations to learn from their mistakes Since customer complaints should be regarded as a learning opportunity, it is important to identify what drives customer complaints. Through experimental designs using a failed service in the restaurant, we investigated whether all angry customers complain to the service provider and if not, what prevents them from raising their voice. Results showed that customers who felt powerful complained about a service failure as soon as they were angry; on the other hand, customers who felt powerless were not comfortable making face-to-face complaints in the restaurant although they were very upset. Hospitality practitioners who wish to learn from customer complaints must find ways to encourage customers to speak up when service failures occur. One simple way to enhance customer sense of power in the restaurant setting is to manipulate the menu. Our experiment showed that a subtle phrase embedded in a menu can affect customers’ sense of power. Our findings suggested that participants in the low-power condition indeed complained less in public, reducing opportunities for the service providers to hear from customers. Hospitality companies should understand the effect of power on customer behavior to increase customer feedback
New Analytical Approach for Computation of Band Structure in One-dimensional Periodic Media
In this paper, we present a new approach for the exact calculation of band
structure in one-dimensional periodic media, such as photonic crystals and
superlattices, based on the recently reported differential transfer matrix
method (DTMM). The media analyzed in this paper can have arbitrary profile of
refractive index. We derive a closed form dispersion equation using
differential transfer matrix formalism, and simplify it under the assumptions
of even symmetry and real-valued wavenumber. We also show that under normal
incidence both TE and TM modes must have the same band structure. Several
numerical test cases are also studied and discussed
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Smartphone-Based Paper Microfluidic Particulometry of Norovirus from Environmental Water Samples at the Single Copy Level
Human enteric viruses can be highly infectious and thus capable of causing disease upon ingestion of low doses ranging from 10(0) to 10(2) virions. Norovirus is a good example with a minimum infectious dose as low as a few tens of virions, that is, below femtogram scale. Norovirus detection from commonly implicated environmental matrices (water and food) involves complicated concentration of viruses and/or amplification of the norovirus genome, thus rendering detection approaches not feasible for field applications. In this work, norovirus detection was performed on a microfluidic paper analytic device without using any sample concentration or nucleic acid amplification steps by directly imaging and counting on-paper aggregation of antibody-conjugated, fluorescent submicron particles. An in-house developed smartphone-based fluorescence microscope and an image-processing algorithm isolated the particles aggregated by antibody-antigen binding, leading to an extremely low limit of norovirus detection, as low as 1 genome copy/mu L in deionized water and 10 genome copies/mu L in reclaimed wastewater.University of Arizona National Science Foundation Water and Environmental Technology (WET) Center [IIP-1361815]; Tucson WaterOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Distinct Expression Pattern and Post-Transcriptional Regulation of Cell Cycle Genes in the Glandular Epithelia of Avian Ovarian Carcinomas
The cell cycle system is controlled in a timely manner by three groups of cyclins, cyclin dependent kinases and cyclin dependent kinase inhibitors. Abnormal alterations of cell cycle regulatory mechanisms are a common feature of many diseases including numerous tumor types such as ovarian cancer. Although a variety of cell cycle regulatory genes are well known in mammalian species including human and mice, they are not well studied in avian species, especially in laying hens which are recognized as an excellent animal model for research relevant to human ovarian carcinogenesis. Therefore, in the present study, we focused on comparative expression and regulation of expression of candidate genes which might be involved in the cell cycle program in surface epithelial ovarian cancer in laying hens. Our current results indicate that expression levels of cell cycle gene transcripts are greater in cancerous as compared to normal ovaries. In particular, cyclin A2 (CCNA2), CCND1, CCND2, CCND3, CCNE2, cyclin dependent kinase 1 (CDK1), CDK3, CDK5, cyclin dependent kinases inhibitor 1A (CDKN1A) and CDKN1B were upregulated predominantly in the glandular epithelia of cancerous ovaries from laying hens. Further, several microRNAs (miRs), specifically miR-1798, miR-1699, miR-223 and miR-1744 were discovered to influence expression of CCND1, CCNE2, CDK1, and CDK3 mRNAs, respectively, via their 3'-UTR which suggests that post-transcriptional regulation of gene expression influences their expression in laying hens. Moreover, miR-1626 influenced CDKN1A expression and miR-222, miR-1787 and miR-1812 regulated CDKN1B expression via their 3'-UTR regions. Collectively, results of the present study demonstrate increased expression of cell cycle-related genes in cancerous ovaries of laying hens and indicate that expression of these genes is post-transcriptionally regulated by specific microRNAs
Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2010 Patani.Background: Ubiquitin modification of proteins influences cellular processes relevant to carcinogenesis. CHIP (carboxyl-terminus of Hsc70-interacting protein) is a chaperone-dependent E3 ubiquitin ligase, regulating the stability of heat shock protein 90 (HSP90) interacting proteins. CHIP is implicated in the modulation of estrogen receptor (ESR1) and Her-2/neu (ERBB2) stability. LOX (lysyl-oxidase) serves intracellular roles and catalyses the cross-linking of extracellular matrix (ECM) collagens and elastin. LOX expression is altered in human malignancies and their peri-tumoral stroma. However, paradoxical roles are reported. In this study, the level of mRNA expression of CHIP and LOX were assessed in normal and malignant breast tissue and correlated with clinico-pathological parameters. Materials and Methods: Breast cancer (BC) tissues (n = 127) and normal tissues (n = 33) underwent RNA extraction and reverse transcription; transcript levels were determined using real-time quantitative PCR and normalized against CK-19. Transcript levels were analyzed against TNM stage, nodal involvement, tumor grade and clinical outcome over a ten-year follow-up period. Results: CHIP expression decreased with increasing Nottingham Prognostic Index (NPI): NPI-1 vs. NPI-3 (12.2 vs. 0.2, P = 0.0264), NPI-2 vs. NPI-3 (3 vs. 0.2, P = 0.0275). CHIP expression decreased with increasing TNM stage: TNM-1 vs. TNM-2 (12 vs. 0, P = 0.0639), TNM-1 vs. TNM-2-4 (12 vs. 0, P = 0.0434). Lower transcript levels were associated with increasing tumor grade: grade 1 vs. grade 3 (17.7 vs. 0.3, P = 0.0266), grade 2 vs. grade 3 (5 vs. 0.3, P = 0.0454). The overall survival (OS) for tumors classified as ‘low-level expression’, was poorer than those with ‘high-level expression’ (118.1 vs. 152.3 months, P = 0.039). LOX expression decreased with increasing NPI: NPI-1 vs. NPI-2 (3 vs. 0, P = 0.0301) and TNM stage: TNM-1 = 3854639, TNM-2 = 908900, TNM-3 = 329, TNM-4 = 1.232 (P = NS). Conclusion: CHIP expression is associated with favorable prognostic parameters, including tumor grade, TNM stage and NPI. CHIP expression predicts OS. LOX expression is associated with improved NPI. In addition to their prognostic utility, mechanistic insights into tumor suppressor function may offer potential therapeutic strategies
Hardness of porous nanocrystalline Co-Ni electrodeposits
The Hall-Petch relationship can fail when the grain size is below a critical value of tens of nanometres. This occurs particularly for coatings having porous surfaces. In this study, electrodeposited nanostructured Co-Ni coatings from four different nickel electroplating baths having grain sizes in the range of 11-23 nm have been investigated. The finest grain size, approximately 11 nm, was obtained from a coating developed from the nickel sulphate bath. The Co-Ni coatings have a mixed face centred cubic and hexagonal close-packed structures with varying surface morphologies and different porosities. A cluster-pore mixture model has been proposed by considering no contribution from pores to the hardness. As the porosity effect was taken into consideration, the calculated pore-free hardness is in agreement with the ordinary Hall-Petch relationship even when the grain size is reduced to 11 nm for the Co-Ni coatings with 77±2 at% cobalt. The present model was applied to other porous nanocrystalline coatings, and the Hall-Petch relationship was maintained. © 2013 The Korean Institute of Metals and Materials and Springer Science+Business Media Dordrecht. © KIM and Springer
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