Generalised optical printing of photocurable metal chalcogenides

Optical three-dimensional (3D) printing techniques have attracted tremendous attention owing to their applicability to mask-less additive manufacturing, which enables the cost-effective and straightforward creation of patterned architectures. However, despite their potential use as alternatives to traditional lithography, the printable materials obtained from these methods are strictly limited to photocurable resins, thereby restricting the functionality of the printed objects and their application areas. Herein, we report a generalised direct optical printing technique to obtain functional metal chalcogenides via digital light processing. We developed universally applicable photocurable chalcogenidometallate inks that could be directly used to create 2D patterns or micrometre-thick 2.5D architectures of various sizes and shapes. Our process is applicable to a diverse range of functional metal chalcogenides for compound semiconductors and 2D transition-metal dichalcogenides. We then demonstrated the feasibility of our technique by fabricating and evaluating a micro-scale thermoelectric generator bearing tens of patterned semiconductors. Our approach shows potential for simple and cost-effective architecturing of functional inorganic materials

Intercomparison of Terrestrial Carbon Fluxes and Carbon Use Efficiency Simulated by CMIP5 Earth System Models

This study compares historical simulations of the terrestrial carbon cycle produced by 10 Earth System Models (ESMs) that participated in the fifth phase of the Coupled Model Intercomparison Project (CMIP5). Using MODIS satellite estimates, this study validates the simulation of gross primary production (GPP), net primary production (NPP), and carbon use efficiency (CUE), which depend on plant function types (PFTs). The models show noticeable deficiencies compared to the MODIS data in the simulation of the spatial patterns of GPP and NPP and large differences among the simulations, although the multi-model ensemble (MME) mean provides a realistic global mean value and spatial distributions. The larger model spreads in GPP and NPP compared to those of surface temperature and precipitation suggest that the differences among simulations in terms of the terrestrial carbon cycle are largely due to uncertainties in the parameterization of terrestrial carbon fluxes by vegetation. The models also exhibit large spatial differences in their simulated CUE values and at locations where the dominant PFT changes, primarily due to differences in the parameterizations. While the MME-simulated CUE values show a strong dependence on surface temperatures, the observed CUE values from MODIS show greater complexity, as well as non-linear sensitivity. This leads to the overall underestimation of CUE using most of the PFTs incorporated into current ESMs. The results of this comparison suggest that more careful and extensive validation is needed to improve the terrestrial carbon cycle in terms of ecosystem-level processes

Surface roughness signatures of summer arctic snow-covered sea ice in X-band dual-polarimetric SAR

Surface roughness of sea ice is primary information for understanding sea ice dynamics and air–ice–ocean interactions. Synthetic aperture radar (SAR) is a powerful tool for investigating sea ice surface roughness owing to the high sensitivity of its signal to surface structures. In this study, we explored the surface roughness signatures of the summer Arctic snow-covered first-year sea ice in X-band dual-polarimetric SAR in terms of the root mean square (RMS) height. Two ice campaigns were conducted for the first-year sea ice with dry snow cover in the marginal ice zone of the Chukchi Sea in August 2017 and August 2018, from which high-resolution (4 cm) digital surface models (DSMs) of the sea ice were derived with the help of a terrestrial laser scanner to obtain the in situ RMS height. X-band dual-polarimetric (HH and VV) SAR data (3 m spatial resolution) were obtained for the 2017 campaign, at a high incidence angle (49.5°) of TerraSAR-X, and for the 2018 campaign, at a mid-incidence angle (36.1°) of TanDEM-X 1–2 days after the acquisition of the DSMs. The sea ice drifted during the time between the SAR and DSM acquisitions. As it is difficult to directly co-register the DSM to SAR owing to the difference in spatial resolution, the two datasets were geometrically matched using unmanned aerial vehicle (4 cm resolution) and helicopter-borne (30 cm resolution) photographs acquired as part of the ice campaigns. A total of five dual-polarimetric SAR features―backscattering coefficients at HH and VV polarizations, co-polarization ratio, co-polarization phase difference, and co-polarization correlation coefficient ―were computed from the dual-polarimetric SAR data and compared to the RMS height of the sea ice, which showed macroscale surface roughness. All the SAR features obtained at the high incidence angle were statistically weakly correlated with the RMS height of the sea ice, possibly influenced by the low backscattering close to the noise level that is attributed to the high incidence angle. The SAR features at the mid-incidence angle showed a statistically significant correlation with the RMS height of the sea ice, with Spearman’s correlation coefficient being higher than 0.7, except for the co-polarization ratio. Among the intensity-based and polarimetry-based SAR features, HH-polarized backscattering and co-polarization phase difference were analyzed to be the most sensitive to the macroscale RMS height of the sea ice. Our results show that the X-band dual-polarimetric SAR at mid-incidence angle exhibits potential for estimation of the macroscale surface roughness of the first-year sea ice with dry snow cover in summer

Changes in Indices of Steatosis and Fibrosis in Liver Grafts of Living Donors After Weight Reduction

BackgroundA short-term weight reduction program for potential living donors was introduced to reduce the extent of hepatic steatosis prior to liver transplantation. We aimed to investigate changes in non-invasive hepatic steatosis and fibrosis indices among those who completed the program. MethodsAmong 1,950 potential living liver donors between January 2011 and May 2019, 160 living donors joined the weight reduction program. The prospectively collected clinical data of these potential liver donors were analyzed retrospectively. Hepatic steatosis and fibrosis scores were determined using the fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD fibrosis score (NFS) and compared to MR spectroscopy (MRS) fat fraction results before and after weight reduction. ResultsThirty-nine potential living donors who had undergone MRS both before and after weight reduction were included in the analysis. Their body weight decreased from 78.02 +/- 10.89 kg to 72.36 +/- 10.38 kg over a mean of 71.74 +/- 58.11 days. FLI, HSI, and MRS values decreased significantly from 41.52 +/- 19.05 to 24.53 +/- 15.93, 39.64 +/- 3.74 to 35.06 +/- 3.82, and 12.20 +/- 4.05 to 6.24 +/- 3.36, respectively. No significant decreases in NFS were observed. There was a significant correlation between the extent of HSI change and the extent of MRS change (R-2 value = 0.69, P < 0.001), although there was no correlation between MRS and FLI. ConclusionThe weight reduction program significantly improved non-invasive indices of hepatic steatosis over a short period. HSI may allow for prediction of simple decreases in hepatic steatosis.N

Additional file 2 of MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer

Additional file 2: Table S4. The kinase inhibition profile of MHY4571

Additional file 1 of MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer

Additional file 1: Figure S1. Design of a novel PKA inhibitor, MHY4571, from the structure of the well-known PKA inhibitor H89. Figure S2. Effect of MHY4571 on cell viability of LC-2/ad cells. Table S1. Key resources table. Table S2. Primer sequence. Table S3. In silico ADME for MHY4571